Top Illinois Artificial Intelligence Startups (195)

Prolaio is a clinical intelligence company dedicated to unlocking continuous, predictive and shareable heart data to liberate patients from hospital-based reactive care and accelerate every new therapy. The company was created by cardiologists, cardiovascular practitioners, and data scientists specifically to address the world’s number one cause of death — cardiovascular disease. By combining scientific rigor with cutting‑edge technology, Prolaio aims...

It’s an exciting time to be a Teragonian! Come help us transform the Private Equity industry and drive AI innovation while taking on new challenges and career growth opportunity.​ Teragonia provides an AI-based Value Orchestration platform for private equity backed mid-market operators, helping them transform fragmented operational data into an execution-focused view of business performance. With Teragonia, mid-market leaders align their...

Caxy is a Chicago based software consulting and custom software development agency founded in 1999. Ranked top 3 software companies in Chicago by Clutch. Our secret sauce is that we want to make life as a developer fun, rewarding and not a grind. We have a commitment we call "The Caxy Promise." Many jobs in software are characterized by clients...

Bectran is an industry-leading SaaS platform which has grown rapidly to become the companion toolkit for the Credit Department just as a CRM is for the Sales Department. Recognized as a top innovator in the credit software industry, Bectran has been described by credit professionals as "the future of the credit department."​

Bellagent is an enterprise-level AI agent platform built to automate everyday business operations with zero-touch integrations that connect instantly to more than 1,300 applications. Launched in 2025 by Proactifi Inc., and headquartered in Chicago, the platform is built for practicality with industry-leading compliance and security standards, enabling organizations to deploy AI agents without friction from day one. Bellagent’s mission to...

At Quantum Rise, we're transforming how businesses use AI, Data, and Automation to fuel growth and innovation. As an AI-native company, we combine human expertise with cutting-edge technology to solve real-world challenges. Our team is passionate about building products that are always on, continuously improving, and designed to help companies get the most out of their existing technology.

Prosodica transforms the way organizations understand and improve human connection. Our AI-powered conversation analytics platform captures every nuance of human dialogue—tone, pacing, empathy, and engagement—and translates it into measurable data that leaders can act on. By quantifying what was once intangible, Prosodica helps enterprises build stronger teams, elevate customer experiences, and create workplaces where communication drives results. At the heart of...

Flatfile, the pioneer of AI-assisted data exchange, provides companies and their software development teams with the easiest, fastest, and safest way to build the ideal data file import experience for their users. Hundreds of companies such as AstraZeneca, Square or Sage rely on Flatfile’s extensible, API-first platform to create enterprise-scale, intelligent, file-based data import solutions, increase developer productivity, reduce cost...

Who We Are Founded in 2001, Adage Technologies is a digital engineering firm building modern, AI‑enabled solutions that help organizations engage their audiences and operate more efficiently. With offices in Chicago and Medellín, our 120‑person team blends strategy, design, engineering, and data to create impactful digital experiences for performing arts organizations, associations and accreditation bodies, and manufacturing and distribution companies. What We...

We put data and AI to work on hard business problems. We embed teams sized to the problem, working inside our clients' operations as partners, not extra hands. We build durable systems that outlast the engagement, and we leave every client more capable and more profitable than we found them.

Beyond Vision is a leading European company specializing in advanced unmanned aerial vehicle (UAV) technology and Artificial Intelligence (AI) algorithms, developing dual-use systems for civil and military sectors.

Moonlite is building a cloud-native experience on-prem. Our software provides the control and customization enterprises need for AI. Build Faster with Moonlite Instantly download and deploy NIMS from NVIDIA or build your own applications with Hugging Face. Customize and deploy AI agents in one click or integrate your own with ease. Total Control Over Your AI Obtain the highest level of security by design...

Citrine Informatics is the award-winning materials informatics platform for data-driven materials and chemicals development. It won the 2017 World Materials Forum Start-up Challenge, the 2018 AI Breakthrough award as the "Best AI-based Solution for Manufacturing," and 2020-2021 Cleantech 100 honors. The Citrine Platform combines smart materials data infrastructure and AI, which accelerates development of cutting-edge materials, facilitates product portfolio optimization,...

Precision’s goal is to provide breakthrough treatments for the one billion patients worldwide suffering from neurological illnesses. We are building the only brain–computer interface that is designed to be minimally invasive, safely removable, and capable of processing large amounts of data. To learn more about how Precision is connecting human intelligence and artificial intelligence, visit www.precisionneuro.io.

WovenX Health is a telehealth company focused on expanding access to specialty care, initially gastroenterology. Its AI-powered platform connects patients with specialty-trained advanced practice providers and physician-supervised care, integrates with electronic medical records, and supports digital intake, clinical routing, and procedure scheduling. By reducing wait times, unnecessary emergency visits, and operational inefficiencies, WovenX helps health systems and specialty practices deliver...

Ultra Tendency is an international Data & AI consultancy that helps organizations design, build, and operate large-scale, data-driven platforms. Its expertise spans data engineering, big data, cloud, streaming, industrial IoT, microservices, analytics, AI, and generative AI. The company works with enterprise customers across Europe and contributes to open-source projects including Apache Kafka, Apache NiFi, Terraform, and Ansible, and other technologies.

We empower patients with secure custody and control of their health data and simplify navigating care. We connect patients with rare and chronic conditions to non-profit communities for support and they can opt-in to sharing confidential insights for research and development, and receive compensation for their contributions. Our healthcare ecosystem is where patients are active participants, care is personalized and...

Basis is a nonprofit applied AI research organization with two mutually reinforcing goals: to understand and build intelligence, and to advance society’s ability to solve intractable problems.

Through our embedded lending infrastructure, we enable platforms to offer capital to their customers in Latin America. R2 has partnered with some of the region's most iconic companies, including Rappi and Clip, to power their capital arms. We are backed by Gradient Ventures (Google's AI-focused fund), General Catalyst, Y Combinator, 166 2nd, Soma Capital, Femsa Ventures, PayU, and other global investors.

Qumis is generative AI built for the hardest part of insurance: understanding the policy. Built by attorneys. Made for scale. Used by the people who make insurance work.