Top Illinois Artificial Intelligence Startups (146)

Prolaio is a clinical intelligence company dedicated to unlocking continuous, predictive and shareable heart data to liberate patients from hospital-based reactive care and accelerate every new therapy. The company was created by cardiologists, cardiovascular practitioners, and data scientists specifically to address the world’s number one cause of death — cardiovascular disease. By combining scientific rigor with cutting‑edge technology, Prolaio aims...

Caxy is a Chicago based software consulting and custom software development agency founded in 1999. Ranked top 3 software companies in Chicago by Clutch. Our secret sauce is that we want to make life as a developer fun, rewarding and not a grind. We have a commitment we call "The Caxy Promise." Many jobs in software are characterized by clients...

At Quantum Rise, we're transforming how businesses use AI and automation to fuel growth and innovation. As an AI-native company, we combine human expertise with cutting-edge technology to solve real-world challenges. Our team is passionate about building products that are always on, continuously improving, and designed to help companies get the most out of their existing technology. But it’s not...

It’s an exciting time to be a Teragonian! Come help us transform the Private Equity industry and drive AI innovation while taking on new challenges and career growth opportunity.​ Teragonia provides an AI-based Value Orchestration platform for private equity backed mid-market operators, helping them transform fragmented operational data into an execution-focused view of business performance. With Teragonia, mid-market leaders align their...

Who We Are Founded in 2001, Adage Technologies is a digital engineering firm building modern, AI‑enabled solutions that help organizations engage their audiences and operate more efficiently. With offices in Chicago and Medellín, our 120‑person team blends strategy, design, engineering, and data to create impactful digital experiences for performing arts organizations, associations and accreditation bodies, and manufacturing and distribution companies. What We...

Bectran is an industry-leading SaaS platform which has grown rapidly to become the companion toolkit for the Credit Department just as a CRM is for the Sales Department. Recognized as a top innovator in the credit software industry, Bectran has been described by credit professionals as "the future of the credit department."​

Bellagent is an enterprise-level AI agent platform built to automate everyday business operations with zero-touch integrations that connect instantly to more than 1,300 applications. Launched in 2025 by Proactifi Inc., and headquartered in Chicago, the platform is built for practicality with industry-leading compliance and security standards, enabling organizations to deploy AI agents without friction from day one. Bellagent’s mission to...

Flatfile, the pioneer of AI-assisted data exchange, provides companies and their software development teams with the easiest, fastest, and safest way to build the ideal data file import experience for their users. Hundreds of companies such as AstraZeneca, Square or Sage rely on Flatfile’s extensible, API-first platform to create enterprise-scale, intelligent, file-based data import solutions, increase developer productivity, reduce cost...

Prosodica transforms the way organizations understand and improve human connection. Our AI-powered conversation analytics platform captures every nuance of human dialogue—tone, pacing, empathy, and engagement—and translates it into measurable data that leaders can act on. By quantifying what was once intangible, Prosodica helps enterprises build stronger teams, elevate customer experiences, and create workplaces where communication drives results. At the heart of...

We deploy self-governing, cross-functional teams that cut through the noise and ship meaningful software in record time. Blending AI tools with senior teams embodying battle-tested experience, we enable our clients to create true competitive advantage through custom software. Try us on for size, we think you'll find that we fit nicely.

We believe in the power of technology to create sustained, differentiated advantage. Our firm helps organizational leaders understand and use emerging digital solutions to drive value across their business. Technology has become an accelerating source of competitive divergence – Cuesta helps companies capitalize on this opportunity with a pragmatic, hands-on approach. Our team has scaled and operated companies across several industries,...

Vidmob is the creative data company. Its AI-based software improves creative and media performance by helping brands and agencies derive their own custom creative best practices, and ensure that those learnings are applied across all flighted media. Vidmob’s approach to using creative data drives brand consistency, reduces creative and media waste, and increases overall business performance across the funnel. As...

HOPPR is building the first multimodal AI foundation model for medical imaging - founded by Khan Siddiqui, (CEO - founder of higi) and Oliver Chen (COO - founder of ilumihealth, acquired by Fosun Pharma) to accelerate AI application development and fine-tuning of AI models. Its deep learning platform is based on a proprietary privacy-compliant trust architecture that brings together data...

Qumis is generative AI built for the hardest part of insurance: understanding the policy. Built by attorneys. Made for scale. Used by the people who make insurance work.

AI-powered cost savings for modern logistics

Convr is the leading Artificial Intelligence (AI) company that is digitally transforming commercial P&C underwriting. Convr’s d3 Underwriting™ solution uses data discovery and decision science to empower commercial carriers to achieve underwriting and operational excellence through digitizes submission paperwork, such as ACORD applications and loss runs reducing manual data entry, provides insights on risks from thousands of data sources, uses machine...

MSPbots is the market leader in proactive intelligence solutions for MSPs. Providing customized BI widgets, dashboards, and innovative apps to streamline daily responsibilities. With our solutions, we generate trackable metrics, send instant messages with issue explanations and resolution steps, and escalate recurring issues to managers for immediate action. MSPbots is dedicated to providing data-driven process automation to enable the growth...

FleetPulse™ is the leading trailer telematics company that enables end-to-end visibility into trailer safety and cargo security, serving customers with OEM-agnostic wired and aftermarket telematics offerings. Based in Chicago, Illinois, FleetPulse combines deep roots in the trucking industry with expert tech talent and offers telematics solutions across a comprehensive portfolio of devices, from hard-wired, OEM-installed sensors to easy-to-install aftermarket sensors and...

Arturo is an AI property analytics company that empowers companies with unparalleled property insights to make the most innovative and best decisions for their business and clients. Arturo delivers on-demand property data utilizing multi-source imagery via a configurable API, enabling better risk assessment.

Citrine Informatics is the award-winning materials informatics platform for data-driven materials and chemicals development. It won the 2017 World Materials Forum Start-up Challenge, the 2018 AI Breakthrough award as the "Best AI-based Solution for Manufacturing," and 2020-2021 Cleantech 100 honors. The Citrine Platform combines smart materials data infrastructure and AI, which accelerates development of cutting-edge materials, facilitates product portfolio optimization,...