Top Illinois Artificial Intelligence Startups (125)

Prolaio is a clinical intelligence company dedicated to unlocking continuous, predictive and shareable heart data to liberate patients from hospital-based reactive care and accelerate every new therapy. The company was created by cardiologists, cardiovascular practitioners, and data scientists specifically to address the world’s number one cause of death — cardiovascular disease. By combining scientific rigor with cutting‑edge technology, Prolaio aims...

Flatfile, the pioneer of AI-assisted data exchange, provides companies and their software development teams with the easiest, fastest, and safest way to build the ideal data file import experience for their users. Hundreds of companies such as AstraZeneca, Square or Sage rely on Flatfile’s extensible, API-first platform to create enterprise-scale, intelligent, file-based data import solutions, increase developer productivity, reduce cost...

At Quantum Rise, we're transforming how businesses use AI and automation to fuel growth and innovation. As an AI-native company, we combine human expertise with cutting-edge technology to solve real-world challenges. Our team is passionate about building products that are always on, continuously improving, and designed to help companies get the most out of their existing technology. But it’s not...

Bectran is an industry-leading SaaS platform which has grown rapidly to become the companion toolkit for the Credit Department just as a CRM is for the Sales Department. Recognized as a top innovator in the credit software industry, Bectran has been described by credit professionals as "the future of the credit department."​

Recognized by Crain’s as one of 2025’s Most Innovative Companies, UncommonX helps customers move from reactive defense to proactive resilience, with the context, prioritization, and insights needed to reduce risk and respond with precision. We believe cybersecurity should deliver more than alerts — it should deliver clarity, confidence, and control. That’s why we built an AI-powered Exposure Management platform that gives...

Prosodica transforms the way organizations understand and improve human connection. Our AI-powered conversation analytics platform captures every nuance of human dialogue—tone, pacing, empathy, and engagement—and translates it into measurable data that leaders can act on. By quantifying what was once intangible, Prosodica helps enterprises build stronger teams, elevate customer experiences, and create workplaces where communication drives results. At the heart of...

Focused is a software services company that builds agentic AI and custom software. Our expert engineers and designers build custom agents that integrate seamlessly with the systems you already run. What sets Focused apart is our hands-on, collaborative approach. We don’t just build and deliver software, we partner with your teams to ensure that we are building the right solution...

Every year, $600bn of freight is coordinated primarily over legacy channels like phone, fax, and email. Fraight AI is building an artificial intelligence powered freight broker that coordinates FTL shipments through those same legacy channels, but at next-generation speeds.

Reveal helps legal professionals solve complex discovery problems. As a cloud-based provider of eDiscovery software, Reveal offers the full range of processing, early case assessment, review and artificial intelligence capabilities. Reveal clients include Fortune 500 companies, legal service providers, government agencies and financial institutions in more than 40 countries across five continents. Featuring deployment options in the cloud or on-premise,...

Data Products is a consultancy and R&D firm based in Chicago, IL. We partner with organizations to deliver deep expertise, objective insights, a tailored approach, and unparalleled collaboration in data science, data strategy, machine learning, artificial intelligence and analytics.

HOPPR is building the first multimodal AI foundation model for medical imaging - founded by Khan Siddiqui, (CEO - founder of higi) and Oliver Chen (COO - founder of ilumihealth, acquired by Fosun Pharma) to accelerate AI application development and fine-tuning of AI models. Its deep learning platform is based on a proprietary privacy-compliant trust architecture that brings together data...

When is a comprehensive, AI-driven technology platform and healthcare severance solution that provides unparalleled support for employees navigating offboarding, life changes, and the complex health insurance market, all while saving your company time and money.

Ritain.io is a technology & consulting services company specialized in Cloud & DevOps, SW Quality Assurance, RPA and AI/Data Science. We are Readiness IT’s Automation Center of Excellence. Readiness IT’s Group has 500+ consultants, offices in three continents, and clients around the globe. Born and raised in the telecom / digital service providers world, our purpose is to act as agents of change in the...

At eMeasurematics, we specialize in industrial autonomous solutions, digital warehouses and yard management systems. Our solutions encompass an advanced software suite which is seamlessly integrated with advanced digital devices. We are industry leaders in our field of technology. As we continue to grow, build better solutions, and add new modules to our software platform, involving A.I, Computer Vision and other...

We are a team of computing innovators and AI visionaries fighting for the reality of a paperless world - a world beyond the simple digital scanning and storage of documents. Our collaborative and boundary-pushing team builds powerful machine learning software integrations to turn unstructured documents into intelligible and immediately accessible data. In a world of information overload and an avalanche...

Monument is an AI-centric software platform designed to create an easy and enjoyable way to back up, manage, and interact with our photos and videos. Developments in technology and social networks have now made content creation easier than ever which in turn has amplified the very real need for content organization.

Welcome to HatchWorks - Your AI and Data transformation partner. We help you unlock AI’s value through the power of your data. It is easy to do AI. It is hard to do well. We act as your guide enabling you to maintain control of your strategy and ownership of your IP while helping you avoid pitfalls along the journey.

CoLane is a workflow automation company disguised as a freight brokerage. We’re automating the $300B Contract Truckload Freight Market with an Human + Machine, tech-enabled services approach. We’ve built Archie (our AI bot) to be able to automate 80% of the boring, routine tasks that are critical to a freight broker.

Realtime generalized artificial intelligence for distributed systems. Your devices are about to get much, much smarter.Quorum Robotics develops artificial intelligence libraries that leverage the efficiency of true brain operating principles to achieve unprecedented flexibility and speed of learning.

We’re leading the world of regulatory compliance forward by offering greater efficiencies, greater cost savings, and greater accuracy. Using market-leading RegulationAI, Ascent helps customers in financial services automate their compliance programs, significantly reducing their risk while saving time and money.