Top Remote Software Engineer Jobs in St. Louis, MO

Develop and maintain scalable Python/Django backend features for Cyware’s Cyber Fusion platform across commercial and AWS GovCloud environments. Design microservices, REST APIs, AI and RAG integrations, multi-tenant architectures, and secure identity systems. Ensure FedRAMP/GovRAMP compliance through secure coding, audit logging, RBAC, encryption, testing, and continuous monitoring. Collaborate with DevOps, GRC, Security, and engineering teams on CI/CD, code reviews, production support, and platform improvements.

The Senior Software Engineer designs and develops software applications, optimizes APIs and databases, collaborates with teams, and ensures code quality through various testing practices.

Leads architecture and development of scalable Node.js SaaS applications and data products. Responsibilities include designing systems, translating stakeholder needs into technical backlogs, writing user stories, coordinating architecture decisions, supporting product planning, improving business processes, and mentoring engineers. The role also incorporates AI-assisted development, code review agents, LLM APIs, agentic workflows, and generative AI tools.

Define architecture and metrics for autonomous driving evaluation, lead cross-functional integration across autonomy and simulation teams, develop statistical and machine learning methods, analyze large-scale time-series data, manage evaluation KPIs and release gates, and communicate safety and readiness insights through dashboards and stakeholder presentations.

Design, build, and own scalable multi-tenant SaaS applications across frontend, backend, and data layers. Improve system architecture, performance, reliability, and testing practices. Integrate AI-assisted tools, mentor engineers, conduct code reviews, and collaborate with Product and Design to deliver intuitive, production-grade software.

Build and own full-stack features for a global peer-to-peer learning platform. Responsibilities include defining problems with users and stakeholders, developing prototypes and experiments, writing maintainable code, coordinating contributions, deploying products, and improving existing systems. The engineer will also participate in code reviews, pair programming, product ideation, and technical decisions balancing speed, quality, safety, and user experience.

Designs, develops, and leads scalable healthcare software solutions involving transaction processing, interoperability standards, integrations, and data platforms. Provides hands-on engineering, architectural leadership, quality ownership, risk management, technical mentorship, and cross-functional collaboration. The role requires building high-performance cloud-based SaaS solutions using microservices and serverless architectures, while guiding engineering strategy and ensuring secure, reliable delivery.

Design and build complex customer-facing product features, own technical decisions, contribute to architecture and technical direction, uphold code quality, mentor engineers, and support production incidents. The role collaborates closely with Product and Design across a modern web stack including React, TypeScript, Node.js, .NET, relational databases, and Microsoft Azure.

Lead development of Device OS platform infrastructure connecting industrial machines and applications to Apkudo. Own integration services, APIs, software and model deployment, staged rollouts, rollback, fleet monitoring, telemetry, diagnostics, and operator-facing control surfaces. Partner with robotics, AI, design, and operations teams to create reliable interfaces and deployment workflows for heterogeneous distributed devices.

Build and own Android growth and monetization experiments across subscriptions, advertising, purchases, and upgrade flows. Partner with product, design, data science, and analytics to instrument experiments, evaluate results, and ship reliable experiences at consumer scale. Use AI-native workflows for specification, coding, testing, and review; improve mobile engineering practices; contribute to architecture and code reviews; participate in on-call; and mentor engineers.

Develop and ship features for mobile games across Unity/C# clients and Go backend services. Collaborate with Product, Design, and Art, troubleshoot live-product issues, improve code quality, maintain build and content pipelines, conduct testing and code reviews, support releases, and investigate regressions. The role requires ownership from implementation through production with limited supervision.

Leads architecture and development of Trellix’s high-throughput cloud threat detection platform. Designs microservices, asynchronous submission pipelines, sandbox execution systems, full-stack analyst interfaces, secure AWS infrastructure, identity integrations, telemetry pipelines, and compliant multi-region architectures. Owns infrastructure as code, observability, production reliability, security practices, technical documentation, incident response, and SLA commitments while integrating AI-assisted development tools.

Build and scale reliable software systems supporting donor platforms, cash payments, and rapid-response programs. Own features end to end from architecture through deployment and monitoring, improve CI/CD and testing, troubleshoot production issues, and collaborate with product, operations, and data teams. The role also contributes to technical roadmaps and sustainable engineering practices in a mission-driven, fully remote organization.

Design and deliver scalable full-stack enterprise applications using Node.js and Vue.js. Lead architecture and technical design, integrate AI/ML capabilities, optimize development with AI-assisted tools, contribute to cloud deployments and CI/CD, and ensure security, observability, performance, and maintainability. Mentor junior engineers and collaborate with product, data, and AI teams.

Own and evolve scalable distributed systems, REST APIs, backend services, and core product areas. Design solutions, improve resilience, reduce technical debt, and drive modularization. Use AI-first and agentic development practices, evaluate emerging AI tools, and help integrate AI across engineering workflows. Collaborate asynchronously with product, data, and go-to-market teams while improving engineering tools, processes, and system reliability.

Architect and deliver distributed backend systems and infrastructure supporting customer service and KYC compliance workflows. Set technical direction, define roadmaps, lead end-to-end project delivery, mentor engineers, and build reliable high-scale services using Go, gRPC, TypeScript, React, cloud infrastructure, and DevOps tooling. Partner across teams and time zones to improve platform capabilities, workflow efficiency, cost, quality, customer satisfaction, and compliance outcomes.

Build and maintain scalable backend applications, serverless functions, microservices, data workflows, ETL pipelines, and cloud-native architectures using Python and AWS. Manage databases, APIs, batch jobs, and real-time integrations while optimizing performance, scalability, security, compliance, and cost. Collaborate with product, engineering, analytics, and data teams; contribute to architecture, CI/CD, infrastructure automation, development standards, and technical mentorship. Healthcare claims data experience is required.

Build full-stack features for a real-time collaborative content platform, spanning backend services, APIs, and frontend systems. Design and implement maintainable, well-tested software; contribute to architecture and technical decisions; collaborate with product and design; integrate AI into development and product workflows; participate in code reviews; and help establish engineering quality standards on an early-stage team.

The Senior Software Engineer for the Treasury team will develop backend services for fund management, ensuring system reliability and leading projects in a fast-paced environment.

Leads architecture and development of Thunderbird’s web-based Services products, including calendar and secure file storage offerings. Responsibilities include writing code, prototyping, selecting technologies, developing analytics and infrastructure, solving complex problems, guiding product direction, mentoring engineers, and improving scalability and sustainability. The role collaborates across engineering, product, design, QA, Mozilla, and open-source communities in a fully remote environment.

Lead architecture and technical direction for Thunderbird’s web-based Services products, including calendar and secure file storage offerings. Responsibilities include writing code, prototyping, making technology decisions, developing analytics and infrastructure, solving complex problems, mentoring engineers, collaborating across product and design teams, and improving system scalability and maintainability. The role also contributes to product growth, open-source collaboration, and data-informed decisions within a fully remote international team.

Build and scale Daymark Health’s cancer care platform across the stack. Responsibilities include developing secure infrastructure and core systems, collaborating with product, data, operations, and customers, integrating workflows, following HIPAA and SOC 2 controls, handling PHI securely, and using AI coding tools to accelerate development. The role requires contributing to technical strategy, improving user experience, and adapting quickly in a startup environment.

Build and maintain fundraising technology that supports donors, fundraisers, donation processing, and reporting. Responsibilities include website development, backend integrations, legacy-system maintenance, data processing, testing, launches, bug fixes, incident ownership, and on-call support during peak donation periods. The role requires autonomous work with Laravel, PHP, JavaScript, HTML, CSS, Salesforce, WordPress, SQL, and partner CSV files, along with close collaboration with non-engineering fundraising teams.

Designs, develops, tests, debugs, and maintains scalable React Native mobile applications for iOS and Android. Owns major mobile projects, defines architecture and APIs, manages backend and third-party integrations, improves performance and reliability, and supports modernization efforts. Collaborates across engineering, product, design, QA, security, and business teams while mentoring engineers and promoting Agile, CI/CD, testing, documentation, and mobile development best practices.

Design and lead the technical strategy for search across Vannevar’s products. Build and improve full-text, vector, and LLM-powered retrieval systems, optimizing latency, relevance, index quality, freshness, and performance. Collaborate with ML, product, design, and mission strategy teams to translate user needs into search innovations. Apply expertise in information retrieval, NLP, machine learning, indexing, ranking, query parsing, tokenization, vector search, and evaluation frameworks.