Top Remote Python Jobs in St. Louis, MO

The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.

Develop and maintain Python applications focusing on iterators/generators/streams, concurrency (multithreading, non-blocking I/O), and high-precision numeric handling. Work with JSON/XML, REST and SOAP APIs, ACID-compliant databases, message brokers/queues, and produce clean, SOLID code. Unit and integration testing experience is beneficial.

Work as a Python development intern building applications and APIs, processing and analyzing data, working with databases and data pipelines, contributing to system architecture, writing clean documented code, and collaborating with the team. Strong emphasis on backend development, SQL, ORMs, and REST API design with potential conversion to full-time.

Design, develop, and maintain scalable Python applications and cloud-native solutions. Architect microservices, containerized deployments (Docker/Kubernetes), optimize cloud infrastructure, build CI/CD pipelines, integrate messaging systems, ensure security and high code quality, and mentor junior developers. Generative AI/ML experience is a plus.

Build and maintain Python tools for web scraping, automation, integrations (Airbnb, marketplaces), ad automation, chatbots (Chatwoot), workflow automation (Spiffworkflow), automated tests, and data analysis.

The Senior Full Stack Developer will design, develop, test, and debug software solutions, collaborating with teams and optimizing applications. Responsibilities include user interaction design, back-end functionality, and ensuring software scalability and security.

The Principal Python Engineer will design, build, and maintain backend services and APIs, focusing on system reliability and engineering quality. The role involves working with databases, applying DevOps practices, and leveraging AI for development efficiency.

The Python Engineer will write maintainable Python software, lead technical initiatives, collaborate globally, and contribute to community engagement at Canonical.

Develop, design, and deliver complex Python backend applications for acquiring, storing, and computing on large volumes of data. Lead feature implementation, ensure code quality via linting and automated tests, mentor junior developers, perform code reviews, collaborate with cross-functional teams, and troubleshoot production issues.

Develop and maintain scalable Python backend applications and RESTful APIs. Optimize performance, design and manage SQL/NoSQL schemas, implement security/authentication, write tests, automate CI/CD tasks, and collaborate with front-end, product, and QA teams.

Develop and maintain scalable, high-volume web and mobile systems as a Python full-stack developer. Implement backend services in Python, build React frontends, design microservices on AWS, follow Scaled Agile practices, and collaborate with offshore teams. Bachelor's degree or equivalent required.

Build and maintain Python backend services and serverless architectures for a restaurant operations platform. Ship end-to-end features, design robust systems, and help define product roadmap. Implement CI/CD and productionization, collaborate with product and GTM teams, and contribute to team culture and technical execution.

Contract role to provide Python/C++ expertise for Panda3D game development: review code, suggest improvements, analyze rendering/assets and gameplay, document decisions for AI training, and collaborate remotely in iterative feedback cycles.

The Forward Deployed Engineer will serve as a technical bridge between clients and engineering teams, writing custom code and integrations, while ensuring customer success with Socket's security platform through strong relationships and expert technical guidance.

Design, develop, deploy, monitor, and support APIs and system integrations (Salesforce, REST, third-party). Work directly with clients to gather requirements, troubleshoot and optimize integrations, operate solutions in AWS, collaborate with teams, and mentor junior developers.

Build and ship full‑stack features for transportation management and other client products. Design and implement APIs and UIs, collaborate with product and design, own delivery, write modular testable code, troubleshoot and iterate quickly, and mentor peers.

Build and maintain Django-based web applications, design RESTful APIs, implement frontend features (HTML/CSS/JS), optimize performance and security, collaborate with cross-functional teams throughout the development lifecycle.

As a Software Engineer III, you will design, develop, and maintain high-quality software solutions, collaborating with cross-functional teams to ensure scalability and performance.

The Senior Software Engineer will build a large-scale data ingestion and classification system using web scraping, data processing, and search technologies, overseeing data extraction from various sources and developing search capabilities.

Own and evolve ClickHouse's Python connector and SDKs; build and maintain integrations with orchestration and transformation tools; design AI/LLM integration patterns (RAG, embeddings, feature stores); engage with open-source community; collaborate with Product and Cloud teams to prioritize and ship production-grade data integrations.

As a Staff Software Engineer, you’ll lead the design and reliability of Duetto's data lakehouse, evolving data systems using Python and AWS, ensuring data quality, and implementing AI-driven solutions.

Develop and maintain backend solutions, ensuring performance, security, and regulatory compliance, while collaborating in cross-functional teams.

Build and maintain API services for a decentralized exchange, design and implement trade routing logic for optimized cross-chain swaps, integrate features with cross-functional teams, monitor system performance and reliability, and troubleshoot trade execution and API issues.

Design and build applications using Python, manage component design, optimize performance, and collaborate with clients on innovative products.

We are seeking a software engineer to build and validate resilient distributed systems, enhance CI pipelines, and improve testing strategies for cloud applications.