Top Remote IT Jobs in St. Louis, MO

Supports end-to-end strategic sourcing for IT and indirect categories, including category strategy, RFx events, bid analysis, negotiations, contracting, supplier onboarding, performance management, savings tracking, risk mitigation, sustainability, and compliance. Partners with IT, Security, Finance, Legal, and business stakeholders while maintaining dashboards, spend analytics, and process improvements.

Leads risk-based IT audit projects covering planning, testing, reporting, IT controls, SOX/MAR compliance, and external auditor coordination. Evaluates control environments, identifies risks and deficiencies, recommends improvements, and communicates findings to management. Leads audit teams, mentors staff, supports professional practice initiatives, develops dashboards and automation, maintains methodology and policies, and builds relationships with business and IT process owners.

Designs and deploys AI/ML solutions from prototype through production for government clients. Responsibilities include generative AI using LLMs and RAG, intelligent classification, agentic frameworks, AI coding tools, legacy-system integration, and automated reporting. The role also establishes AI/ML roadmaps, scales adoption, communicates technical concepts to stakeholders, and mentors data scientists.

Leads enterprise-wide IT and digital transformation strategy, roadmap development, ERP and business application modernization, enterprise architecture, commercial systems, global invoicing, and post-merger technology integration. Oversees transformation portfolios, budgets, vendors, governance, compliance, and value realization across manufacturing, quality, supply chain, finance, human capital, and commercial operations. Builds high-performing technology teams and partners with executives to deliver measurable operational, financial, and customer experience improvements in a regulated environment.

Lead the corporate IT organization, including helpdesk and IT engineering, while aligning technology with strategic business goals. Define the IT vision, roadmap, metrics, budget, and resource allocation; drive AI automation, operational excellence, employee engagement, and continuous improvement. Partner with senior leaders and teams including HR Tech, Security, PMO, and Helpdesk to prioritize initiatives and deliver scalable solutions. Manage hybrid and international teams while developing talent and maintaining IT as a service-oriented strategic partner.

Identify and validate AI opportunities across IT operations and cybersecurity, including service management, threat detection, infrastructure monitoring, identity access, endpoint protection, and vulnerability management. Translate operational challenges into structured use cases, assess business value and risk, document data and integration requirements, promote responsible AI, facilitate stakeholder workshops, build internal champions, and monitor emerging AI capabilities while supporting security compliance and change management.

Manage global accounting and financial planning IT projects and programs: lead cross-functional and vendor teams, prioritize requirements, create schedules, track risks and milestones, drive technical builds, integrations, testing, and delivery using Agile/Waterfall/hybrid methodologies.

Provides remote help desk and training support for Medicaid Integrity Institute participants. Manages portal access and email inquiries, troubleshoots real-time user issues, tracks requests in Jira, resolves incidents, monitors inquiry trends, and identifies process improvements. The role requires responsive customer service, clear written communication, collaboration with a remote team, and working hours aligned with Pacific Time before, during, and after training events.

Design, configure, and maintain ServiceNow ITSM workflows and integrations. Build upgrade-safe scoped apps, manage CMDB/CSDM, implement automation (Flow Designer, scripts), develop/integrate REST/SOAP APIs, support upgrades and ATF, and collaborate with stakeholders in Agile teams to deliver platform solutions and mentor teammates.

Manage project tasks and resource needs across multiple task orders supporting federal scientific peer review programs. Serve as an internal contact for operational, compliance, and reviewer inquiries; oversee team tasking and training; monitor application compliance; prepare reports and deliverables; coordinate reviewers; and provide virtual and onsite panel support. The role requires strong organization, communication, attention to detail, and proficiency with Microsoft Office and Adobe Acrobat.

Designs, deploys, and maintains enterprise cloud and on-premises network security (NGFW, SASE/SSE, visibility, micro-segmentation). Executes migrations, policy cleanup, automation, monitoring, documentation, and escalations. Collaborates across teams, coaches junior staff, and supports hardware/software acquisitions to sustain managed security services.

Administer Epic’s corporate identity, access, endpoints, applications, devices, and employee IT support. Manage onboarding and offboarding, access reviews, authentication and device standards, MDM provisioning, asset inventories, procedures, and audit evidence. Support SOC 2 or similar compliance activities, security reviews, and incident response while partnering with infrastructure and people operations. This is a fully remote, US-based role supporting a global engineering team.

Design, configure, and extend the ServiceNow platform including Service Portal, Catalog, ACLs, Flow Designer, integrations, Document Intelligence, and workplace modules. Develop client/server scripts, widgets, and automation; support upgrades, ATF, instance cloning, and platform governance. Collaborate in Agile with stakeholders, mentor junior staff, estimate work, and drive solution design and process improvements.

Manage enterprise IT projects for IRS Criminal Investigation: plan, coordinate, and execute initiatives from initiation through closure. Oversee scope, schedule, budget, risk, resources, stakeholders, and change control. Track/report milestones, drive issue resolution, and lead cross-functional teams to deliver infrastructure, endpoint, and software deployment projects on time, secure, and compliant.

Serves as the liaison among business stakeholders, dealerships, and IT teams supporting Dealer Management System applications. Gathers and translates requirements, facilitates solution workshops, evaluates application enhancements, and supports configuration, testing, implementation, training, and optimization. The role assesses risks, prioritizes business needs, creates use cases and user stories, supports Agile and Waterfall delivery, and develops technology recommendations and architecture documentation aligned with business objectives.

Owns Okta identity and access management, including SSO, MFA, lifecycle workflows, entitlement governance, contractor access, and automated provisioning. Administers Jira, Confluence, and related Atlassian platforms at organizational scale. Designs identity and platform architecture, automates access processes, reduces security risk, maintains audit-ready documentation, and partners with Information Security and IT Operations on governance, remediation, and continuous improvement.

Lead enterprise solution architecture and modernization of legacy IBM mainframe financial applications. Analyze current-state systems, design cloud-enabled future-state architectures, map business processes, and guide migrations involving COBOL, JCL, CICS, DB2, and VSAM. Provide technical leadership across integration, data migration, interoperability, documentation, testing, and deployment. Collaborate with financial agencies and development teams to implement modern solutions using Java, Spring Boot, APIs, microservices, databases, cloud platforms, and DevSecOps practices.

Provides global presales technical expertise for IT virtualization and infrastructure modernization solutions. Partners with account executives, engages customers, leads architecture discussions, presents solutions, advises on virtualization and migration strategies, develops service scopes, and supports pricing and delivery alignment. Requires deep virtualization architecture experience across VMware or related platforms, cloud, containers, security, AI, and infrastructure modernization.

Administer and optimize SQL Server databases while designing normalized schemas, mapping XML data, and developing SSIS-based ETL and migration pipelines. Responsibilities include database maintenance, backup and recovery, performance tuning, security controls, audit logging, testing, production cutovers, rollback planning, and ongoing migration support. The role also requires collaboration across development, testing, systems engineering, and business teams.

Oversee and finalize legal documents governing data sharing between Healthcare Fraud Prevention Partnership members and a trusted third party. Collaborate with CMS, HFPP leadership, partner engagement teams, and private payer partners on agreements, compliance, and negotiations. Present to management, support partner relationships, and ensure legal requirements are met for data governance and sharing.

Lead administration of Microsoft 365, Google Workspace, SaaS applications, Azure identity, and cloud infrastructure in a fully cloud-based organization. Provide Level 2/3 service desk escalation, execute migrations and cybersecurity projects, establish IT service processes, manage assets and vendors, and support onboarding, offboarding, incident response, change management, and M&A initiatives. The role partners with IT leadership and may help build and manage a growing internal technical team.

The Senior Clinical Trials IT Business Analyst bridges Clinical Development and IT, optimizing clinical trial technologies and managing system implementations, validations, and stakeholder engagement.

Lead human-centered design and front-end engineering for the NIH Data Lakehouse: conduct user research and testing; create wireframes, prototypes, flows, and accessible interfaces; build scalable React/Next.js/TypeScript UI components; integrate with GraphQL and search services; contribute to design systems, component libraries, and platform-wide front-end best practices.

Maintains provider demographic, credentialing, enrollment, participation, roster, and directory data across healthcare systems. Reconciles rosters, audits data quality, resolves discrepancies affecting claims and participation, supports credentialing and enrollment, produces operational reports, communicates with stakeholders, and recommends process and tooling improvements.

Lead the strategic direction of frontend engineering, architecture, tooling, and standards. Build accessible, high-performing React or Angular applications, component libraries, design systems, deployment pipelines, and testing strategies. Drive modernization, performance, accessibility, and developer-experience initiatives while collaborating with product and design teams. Mentor engineers, influence cross-team technical decisions, and contribute across the full stack when needed. The role is remote, requires U.S. citizenship and the ability to obtain Public Trust 6C, and involves up to 10% travel.