Top Remote Python Jobs in San Diego, CA

Senior full-stack engineer responsible for designing and building end-to-end features across frontend (TypeScript + React) and backend (JVM languages, Python/Node.js). Owns code quality, testing, CI, and collaborates in agile teams. Mentors junior engineers, participates in code reviews and pair-programming, and works with cloud, databases, and distributed systems. Remote role with occasional in-person meetups.

As a Senior Software Engineer at Vanta, you will design and build internal tools for go-to-market teams, focusing on applications that enhance sales and customer engagement, employing modern tech and AI workflows.

Design, build, and maintain AI-driven automations and integrations across Zendesk, Salesforce, ClickUp, and chatbots to reduce manual support work, improve CX, and measure automation impact. Own end-to-end lifecycle, monitor reliability, iterate with stakeholders, and expand LLM capabilities and reusable AI patterns.

Lead and sustain large-scale HPC systems supporting NOAA/NWS forecasting. Manage scheduler/software stack (PBS Pro/Slurm), optimize performance and throughput, troubleshoot multi-node Linux clusters, develop scripts, and support 24/7 operations with occasional travel and on-call duties.

Lead post-sales integrations for Element451: validate SOWs, architect and scope SIS and other integrations, run engineering delivery through build/UAT/go-live, operate maintenance and live support, set processes/tooling, partner with Product to productize integrations, and measure delivery KPIs.

Serve as a technical partner between Customer Success and Engineering to resolve complex enterprise escalations, debug live production systems, perform root cause analysis, build scripts and diagnostic tools for self-service, and participate in a rotating on-call schedule to ensure fast, expert client resolution.

Design, build, and maintain scalable automated workflows and integrations using platforms like n8n, Zapier, Make, or Workato. Integrate systems via APIs/webhooks, troubleshoot workflow issues, monitor performance, document processes, and support data synchronization across CRMs and business tools while collaborating with cross-functional teams.

Design, build, and operate scalable, secure cloud infrastructure and CI/CD pipelines. Manage Kubernetes environments, implement IaC (Terraform), improve observability, troubleshoot production issues, support security/compliance, and mentor junior engineers to optimize platform reliability and cost.

Design reproducible coding environments and high-quality reference solutions to train AI. Create and validate complex programming challenges, debug and optimize codebases, refactor legacy systems, document technical decisions, and review technical submissions while collaborating remotely.

The Senior Software Engineer will design and implement backend solutions for a social casino platform, collaborate with team members on architecture, and review code, while ensuring the product meets user needs.

Forward Deployed Engineers at Luma build systems based on customer workflows, defining problems and delivering production solutions using Luma's models and APIs.

Senior backend engineer responsible for designing and implementing Flask-based services, optimizing performance and scalability, maintaining and enhancing applications, writing clean documented code, conducting performance tests, ensuring UI/UX feasibility, and collaborating with frontend teams and stakeholders during discovery.

Design APIs, build scheduling algorithms for GPU utilization, create resource management systems, and collaborate with frontend engineers for AI infrastructure.

Research Engineers will build QA systems for training data, define quality standards, audit datasets, and collaborate with data vendors to enhance data generation processes.

Develop and optimize GPU-accelerated algorithms for quantum circuit simulations, collaborating with various teams, and leading technical efforts.

As a Fullstack Software Engineer, you'll develop critical applications for Hadrian's FactoryOS, collaborating with teams to enhance manufacturing processes.

Create user-centric API and SDK documentation and programming guides for developer audiences. Collaborate with engineering, product, and integrations teams to produce clear, story-driven API content using style guides, markup languages, and OpenAPI/Swagger specifications.

The Deployment Engineer will build and operate AI inference clusters, ensure scalable deployments, optimize allocation, and maintain infrastructure. Responsibilities include software updates, telemetry development, and collaborative improvements with teams.

The role involves building and integrating full-stack features for an AI chat application, focusing on reliable workflows and real-time AI interactions.

The Senior Backend Engineer will develop, test, and maintain scalable integrations, support cross-functional teams, and enhance developer experiences.

The Staff Software Engineer will design and develop scalable cloud services, focusing on AI infrastructure, with hands-on system architecture, mentoring, and engineering culture shaping responsibilities.

Lead a 6–8 engineer team building an SSH client, web app, and backend services for an agentic AI platform. Own architecture, hiring, process, roadmap partnership with product, incident response, and mentorship while remaining ~20% hands-on.

Lead reliability and performance efforts for distributed metadata systems: tune and optimize systems, develop monitoring and automation, manage rollouts, troubleshoot incidents, run simulations and analytics, and support database/configuration management to improve global network stability and capacity.

Perform technical code review and analysis to determine originality and function, prepare memos and expert reports, rebut other experts, communicate with counsel and clients, prepare testifying experts, manage multiple engagements, and supervise junior staff.

Lead silicon bring-up, validation, and production testing for analog front-end (AFE) development, characterizing high-speed DACs, ADCs, and RF interface. Requires collaboration with cross-functional teams and automated measurement systems using Python.