Top Remote Python Jobs in Houston, TX

Designs and automates electrical and optical performance validation tests for photonic integrated circuits and subassemblies. Develops test hardware, software, motion and vision control systems, and production-level test stations. Performs station qualification, Gage R&R, SPC, documentation, troubleshooting, data analysis, and cross-functional communication while tracking test development schedules and milestones.

Own and evolve patient-facing clinical application surfaces, including a React widget, clinician portal, and Python service layer. Lead full-stack architecture, AI application integrations, encounter data flows, internal tooling, versioned shared components, and operational reliability. Partner with AI engineers on LLM-enabled workflows, maintain dependencies, protect consumers from breaking changes, and mentor junior engineers. The role requires durable ownership of rapidly built systems and delivery of critical healthcare technology.

Design, build, test, operate, and improve reliable backend services and APIs. Lead projects from definition through deployment, make scalability and reliability tradeoffs, improve observability, investigate production issues, and collaborate with cross-functional teams to deliver customer-focused solutions.

Design, build, test, and operate scalable backend services and APIs. Lead complex projects, make architecture and reliability tradeoffs, improve observability and incident response, collaborate cross-functionally, influence technical direction, mentor engineers, and drive durable improvements to production systems and developer experiences.

Build, patch, customize, and test Linux userspace packages for Rocky Linux products. Remediate CVEs, improve package-building automation, develop automated system tests, and support deployments across servers, virtual machines, and cloud infrastructure. Collaborate on architecture, proofs of concept, documentation, capacity planning, and launch reviews while contributing to open-source development and CI/CD practices.

Leads end-to-end design, development, quality, and integration of complex software solutions and cloud services. Provides technical leadership for enterprise-wide projects, manages engineering processes, risks, dependencies, and delivery priorities, and writes code across the software ecosystem. Collaborates with multidisciplinary teams to deliver measurable, user-centric technology solutions, primarily supporting healthcare caregivers.

Lead full-stack software development across frontend and backend systems, delivering user-facing healthcare features from concept through iteration. Design APIs and application architecture, write technical specifications, improve testing and CI practices, collaborate with product, AI/ML, clinical, and UX teams, and guide cross-team technical decisions. The role involves React, Python, cloud infrastructure, databases, asynchronous workflows, and healthcare data technologies.

Designs, implements, and supports secure, highly available IBM MQ and MFT integration environments. Responsibilities include AWS cloud infrastructure, Terraform-based infrastructure automation, Python scripting, CI/CD collaboration, security, monitoring, logging, disaster recovery, troubleshooting, and optimization of enterprise messaging and cloud platforms.

Deploys, supports, and improves Managed Services Gateways across cloud and virtualization platforms. Administers Linux, Kubernetes (Rancher), VMware/Hyper-V, networking and firewalls; automates workflows; triages escalations; documents runbooks; coordinates with clients and teams; participates in on-call and lifecycle/security initiatives.

Designs and implements enterprise cloud and AI solutions for unstructured data workloads. Responsibilities include building ingestion pipelines, API integrations, document extraction and HITL workflows, tuning machine learning models, benchmarking performance, and ensuring security, availability, disaster recovery, and data isolation. The role also supports customer developers, leads technical proofs of concept, mentors engineering teams, develops reusable blueprints, and provides feedback to product engineering.

Design and implement scalable first-mile networking solutions for Microsoft 365 Substrate and COSMIC. Drive design, dependency identification, coding, optimization, debugging, and on-call monitoring. Analyze production telemetry to improve reliability, performance, and observability. Act as a DRI, lead design and release plans, and collaborate with stakeholders to meet product requirements at global scale.

Owns delivery of backend money movement and card ledger systems, leading engineers through complex problems and ambiguity. Collaborates with product, design, analytics, and engineering stakeholders; defines scalable technical solutions; supports system availability, monitoring, on-call operations, code quality, and engineering standards. The role also includes mentoring and developing team talent while building highly available distributed systems for Affirm’s financial products.

Own and improve CI/CD, developer tooling, agent harnesses, Kubernetes infrastructure, observability, cost management, and incident-response practices. Build platform capabilities that reduce engineering toil and improve delivery speed for conversational AI products. Participate in an on-call rotation for core infrastructure and help shape reliable, scalable systems across a fully remote engineering organization.

Own the reliability, scalability, and administration of production Vitess/MySQL and Cassandra databases. Design highly available architectures, replication, backup, recovery, security, and disaster recovery strategies. Lead incident response, on-call operations, monitoring, SLO development, root cause analysis, and production readiness reviews. Automate database and infrastructure operations using scripting, Kubernetes, Terraform, Ansible, and Jenkins. Establish runbooks, escalation procedures, training materials, and mentor junior database SREs while partnering across engineering and infrastructure teams.

Lead the architecture, development, and evolution of Keeper Commander, including Python and .NET SDKs, CLI tooling, APIs, and developer automation. Remain hands-on with coding, debugging, architecture, integrations, security, testing, and release engineering while mentoring a small team. Partner with Product, QA, and Security teams, support the open-source ecosystem, improve developer experience, and guide technical strategy for enterprise and DevOps integrations.

Develop and maintain Akamai’s custom Linux kernel and distribution. Responsibilities include adding performance, reliability, and security features; porting modifications to newer kernel versions; debugging production and test issues; improving build and continuous-testing automation; collaborating with platform, application, test, and hardware teams; and contributing work upstream to the Linux community.

Develop and maintain Akamai’s custom Linux kernel for its cloud platform. Responsibilities include adding performance, reliability, and security features; porting modifications across kernel versions; debugging production and test issues; improving build and continuous-testing automation; collaborating with platform, application, hardware, and test teams; and contributing changes upstream to the Linux community.

Build and operate WISEcode’s food data lakehouse using Python, SQL, DuckLake, S3 Parquet, Postgres, and Prefect. Responsibilities include source ingestion, entity resolution, pipeline consolidation, data enrichment, downstream connectors, data quality reporting, configuration discipline, and architectural documentation. The role requires designing and shipping production lakehouse or warehouse systems, managing scalable API-driven pipelines, and collaborating closely with engineers in a fully remote environment.

Leads Clever’s engineering organization and technical strategy, overseeing architecture, execution, production systems, organizational design, recruiting, and leadership development. The role remains technically hands-on through architecture and code reviews, debugging, production support, and direct contribution. It also drives AI-assisted engineering, modernization of legacy systems, engineering productivity, and close collaboration with Product and executive leadership.

Develops high-speed analog ICs exceeding 100 Gbaud for optical networking products. Responsibilities span product definition, circuit design, layout, verification, bring-up, design validation, qualification, testing, characterization, and production ramp-up. The role collaborates with verification, CAD, product, test, operations, and reliability teams and supports system-level customers. Required expertise includes SiGe BiCMOS or CMOS analog design, high-frequency structures, device physics, RF wafer probing, laboratory equipment, and high-speed IC evaluation.

Administers and supports enterprise infrastructure, Windows and Linux environments, Azure, Microsoft 365, virtualization, identity services, PKI, backups, and core banking systems. Automates processes, manages access and security remediation, supports disaster recovery, investigates root causes, maintains technical documentation, and provides Tier 3 and on-call support. Coordinates infrastructure projects, change management, vendor engagements, audits, and lifecycle planning.

Build and maintain full-stack features across core financial platforms using Python, Django, PostgreSQL, and modern JavaScript or TypeScript frameworks. Design scalable systems, implement front-end interfaces and back-end APIs, write automated tests, optimize performance, resolve bugs, participate in code reviews, collaborate cross-functionally, and guide junior engineers while using AI-assisted development tools.

Define the technical vision and multi-quarter strategy for Coinbase’s FinHub financial infrastructure. Architect scalable ledger and money-movement primitives across fiat and crypto, ensuring double-entry accounting, idempotency, reconciliation, auditability, reliability, and safe failure recovery. Lead complex cross-team architectural initiatives, collaborate with finance, risk, compliance, and operations stakeholders, and mentor senior engineers while improving system design and operational excellence.

Principal Software Developer responsible for designing, developing, and scaling distributed, high-throughput software systems. The role delivers features, improves reliability, identifies bottlenecks, leads system migrations from monoliths to microservices, and works across the technology stack. Responsibilities include architectural design, cloud engineering, technical leadership, mentoring developers, communicating technical decisions, and using AI and automation tools to improve engineering outcomes.

Leads site reliability engineering for mission-critical cloud platforms, focusing on disaster recovery drills, platform rebuild validation, infrastructure automation, Kubernetes operations, CI/CD, observability, incident response, and system resilience. Collaborates across engineering, security, applications, and data teams while driving remediation and modernization efforts. The role requires deep AWS, Infrastructure as Code, containerization, automation, monitoring, and failure-analysis expertise, plus eligibility for Public Trust clearance.