Top Remote Software Engineer Jobs in Buffalo, NY

Build and own automation systems that eliminate friction across engineering, operations, and compliance. Responsibilities include regulatory workflow automation, CI/CD and developer productivity tooling, AI- and LLM-enabled internal workflows, system integrations, and reliable production software with testing, observability, auditability, and failure handling.

Build and maintain Python backend services, APIs, healthcare integrations, and reliable platform infrastructure. Collaborate with product, frontend, engineering, and clinical teams to define functionality, ensure safety, troubleshoot production issues, and deliver projects end to end. Contribute to DevOps, CI/CD, observability, testing, code review, and technical architecture for an AI-powered healthcare platform.

Build and maintain reliable integrations between UpDoc and healthcare systems, EHRs, and external APIs. Own integration projects from discovery and architecture through deployment, monitoring, troubleshooting, and maintenance. Develop Python APIs and backend services using FastAPI and Pydantic, implement healthcare interoperability standards, handle failures and data integrity, and create automated tests. Collaborate with healthcare technology stakeholders while supporting security, HIPAA, SOC 2, observability, and clinical reliability requirements.

Leads full-cycle technical implementations of a cloud-based digital banking platform, translating client requirements into configurations, custom SDK/API solutions, integrations, data conversions, testing, and production launches. Manages client environments, troubleshoots technical issues, supports post-launch operations, and coordinates with Product, Engineering, Services, and Support teams. The role also improves implementation processes, documents technical specifications, manages risks, supports performance testing, and mentors junior team members.

Lead and deliver quarterly goals for a backend team; guide engineers through ambiguous problems; collaborate with product, design, and analytics; identify and resolve project and technical issues; ensure operational availability and on-call readiness; set code and design quality standards; and mentor and develop team members.

Sets technical direction for Helix’s Experience platform and broader engineering organization. Designs and implements distributed, full-stack genomic software systems focused on patient and provider experiences. Leads complex projects from scoping through production, advances AI-assisted engineering practices, establishes quality and delivery standards, mentors technical leaders, and drives cross-functional collaboration with product, design, research, scientific, and business teams.

Build and own scalable payments infrastructure for card issuing, transaction processing, and settlement. Design reliable integrations with Stripe, banking partners, and internal platforms using .NET, C#, Azure, DDD, CQRS, and event-driven architectures. Improve system reliability, observability, performance, security, and compliance while mentoring engineers and contributing to technical direction. Apply AI-assisted development across coding, testing, debugging, and engineering workflows.

The Senior Backend Software Engineer will design and scale backend systems using Python and FastAPI, collaborate with researchers, optimize infrastructure, and implement testing and monitoring systems.

Develop scalable web applications using React and Next.js, implement backend solutions in Python, maintain DevOps practices, and collaborate with AI/ML teams to deploy applications.

The Senior Bilingual Software Engineer will align U.S. teams with the Platform Core team in Japan, focusing on high-impact problems and maximizing platform leverage through clear communication and collaboration.

The Backend Software Engineer will develop and maintain backend systems for data processing related to coffee farming, utilizing Python and PostgreSQL. Responsibilities include feature development, problem-solving, and adapting systems to regulatory changes while ensuring system resilience.

Develop and enhance software solutions for mineral exploration, collaborating with geologists and data scientists, and driving insights from data systems.

Join Galaxy Ventures' Talent Network for Software Engineer roles. Connect with crypto portfolio companies for career opportunities and networking events.

The Edge Functions Engineer will evolve the Supabase Edge Runtime, implement monitoring and optimizations, manage features, and work closely with the Deno open-source teams.

The Software Engineer, Backend Engineer will develop, automate, and maintain core functionalities for Rescale customers, focusing on backend systems and cloud services.

Design, build, and maintain scalable end-to-end systems and APIs/SDKs for an enterprise custody platform. Work full-stack across databases, cloud deployments, CI/CD, and security; troubleshoot issues, integrate emerging technologies, and mentor junior engineers.

Design, develop, and maintain scalable web applications using .NET backend and Angular/React frontend. Collaborate on requirements, implement RESTful APIs, optimize performance, debug, maintain documentation, support end-users, and work within CI/CD and DevOps workflows.

Design, develop, customize and integrate Microsoft Dynamics 365 CRM/CE solutions. Build entities, forms, workflows, plugins, reports and dashboards using CRM SDK, C#, JavaScript, ASP.NET and SQL. Troubleshoot issues, estimate implementation approaches, collaborate with stakeholders, document solutions, and mentor junior developers. Banking domain experience preferred.

The Web3 / Full-stack Software Engineer will design, develop, and deploy software solutions for staking products, collaborating with engineers and UX designers to enhance UI and ensure security of blockchain networks.

Design, develop, and maintain high-quality cloud-based applications within an Agile team. Collaborate on architecture, product requirements, and software development; troubleshoot production issues; evaluate technologies; provide technical leadership; and optimize performance through memory management, parallelization, and algorithm efficiency. The role also involves building multitenant database architectures, implementing secure APIs and event-driven systems, writing unit tests, and debugging complex software issues.

As a Founding Software Engineer, you'll design, develop, and maintain robust backend systems, create user-facing AI features, and collaborate with teams to enhance healthcare tools.

Lead full‑stack development and architecture for Spark’s broker platform. Deliver customer‑facing features, partner with product/design, mentor engineers, resolve technical debt, and set engineering standards while using AI developer tools.

As a Senior Software Engineer, you'll develop and build tools for creative projects while leading feature development and collaborating with teammates.

Design, build, and operate backend systems for prediction markets, including order management, trade matching, settlement, and market resolution. Architect distributed, low-latency systems with strict financial correctness, lead multi-quarter technical projects, mentor engineers, and collaborate with Product, Compliance, and Risk to meet regulatory requirements.

Design, build, and operate the GraphQL API platform that routes high-volume traffic. Deliver end-to-end projects, improve reliability and performance, own SLOs and incident response, mentor engineers, and collaborate with product teams to evolve platform APIs and tooling.