Top Senior IT Jobs in Kansas City, MO

Lead end-to-end sales pursuits for IT infrastructure managed services. Build and execute strategic sales plans, penetrate target markets, shape messaging, drive RFP responses and negotiations, and ensure smooth sales-to-delivery transitions while mentoring teams and promoting collaboration.

Lead and enhance Circle's IT SOX compliance program by evaluating ITGCs, automated and IT-dependent controls, documenting SOX-ready materials, coordinating testing and remediations, liaising with IT, Security, Finance and auditors, and driving control design for system implementations and new product launches.

Owns the strategy and execution of eDiscovery and information governance programs across business functions and enterprise platforms. Partners with engineering teams to improve EDRM capabilities, translates regulatory requirements into system controls, manages roadmaps, dependencies, risks, and audit documentation, and validates compliance tooling through comprehensive testing. The role also identifies automation opportunities, responsibly applies generative AI and workflow tools, and drives organizational adoption.

Lead architecture and delivery of IT automations and integrations across platforms (n8n, Airflow, Temporal, Jira). Act as technical DRI for complex automation projects, partner with Security and IAM, build reusable frameworks and documentation, establish engineering standards and code review practices, and mentor peers.

Own IT-specific Sarbanes-Oxley (SOX) compliance for ITGCs and ITACs. Assess SOX readiness for systems and process changes, maintain control documentation, coordinate walkthroughs and remediation, liaise with internal/external auditors, review SOC reports, oversee testing programs, and identify automation and AI opportunities to strengthen controls and reporting.

Own and automate end-to-end employee lifecycle and shared IT infrastructure using infrastructure-as-code and SRE practices. Manage ITSM platform and AI-driven virtual agents, build integrations (Okta, Workday, JAMF, Google Workspace, Slack, Zoom, GitLab), instrument metrics, ensure reliability and compliance, and mentor support engineers.

The Lead Technical Support Engineer resolves complex technical issues, provides mentorship, collaborates with teams, and improves support systems.

Lead enterprise cloud architecture, governance, and infrastructure enablement. Define reusable IaC patterns (Terraform), cloud networking (Transit Gateway, multi-account VPCs), and migration/data center exit strategies. Build architecture review processes, drive adoption of cloud-native practices (Kubernetes, CI/CD), and translate technical decisions for stakeholders while coordinating security and compliance.

Lead and execute remote technical implementations for dental practices from signing through go-live. Configure PMS integrations, set up remote access and network configurations, manage AWS-hosted Windows VMs/ETL, handle support volume, liaise with MSPs, and improve onboarding processes and automation while partnering with cross-functional teams.

Own advanced hardware diagnostics and end-to-end RMA lifecycle for enterprise servers in a production data center. Troubleshoot firmware, BIOS, BMC/IPMI, GPUs, storage and power components; perform root cause analysis, validate failed parts, coordinate OEM warranty replacements, and develop diagnostic playbooks to improve fleet reliability and reduce MTTR.

Provides executive and employee communications during major IT incidents, translates complex technical topics into clear messages, develops presentations and communication strategies, supports communications tools, maintains brand standards, monitors media trends, and produces video content. Advises stakeholders and executives while coordinating Systemwide IT communications and strategic storytelling. The role requires strong writing, editing, storytelling, collaboration, technical aptitude, and the ability to work independently under pressure.

Provides senior-level IT support for desktop computers, laptops, printers, monitors, peripherals, and related hardware. Installs, upgrades, maintains, troubleshoots, tests, repairs, and inventories equipment. Supports users, documents and escalates unresolved issues, coordinates with external support organizations, and serves as a subject matter expert for assigned technologies. The role also includes system maintenance, special projects, equipment receiving, customer service, and hardware inventory management.

Lead and coordinate IT and security audits across cloud infrastructure, application security, IAM, vendor risk, and blockchain products; shape audit roadmap; produce executive- and Board-level reports; drive remediation and validate corrective actions; partner with technology leaders and mentor audit staff.

Lead end-to-end IT and security audits across cloud infrastructure, application security, IAM, vendor risk, and blockchain products. Plan and execute fieldwork, produce evidence-based reports for senior leaders and the Audit Committee, mentor junior auditors, validate remediation, and partner with Engineering and Security to improve controls while maintaining audit independence.

Plans, executes, and reports on IT audits covering technology systems, business applications, risk departments, controls, and processes. Performs risk-based testing, process walkthroughs, operating-effectiveness testing, documentation, audit interviews, risk and control assessments, and communicates findings to clients and audit teams. Maintains knowledge of audit standards and technology best practices while managing multiple initiatives.

Lead IT strategic sourcing for software, cloud, infrastructure, telecom, cybersecurity, and services. Develop category strategies, negotiate contracts, manage supplier performance and risks, drive cost-savings, maintain sourcing pipeline, ensure compliance with procurement, privacy, and security requirements, and collaborate cross-functionally to implement procurement initiatives.

Provide Tier 2 technical support and own escalations across devices, apps, and cloud platforms. Administer enterprise SaaS (Google Workspace, Atlassian, Okta, Jamf, Slack), perform root cause analysis, build SOPs/KB content, partner with cross-functional teams, and use automation and generative AI responsibly to reduce tickets and improve service.

Provides global presales technical expertise for IT virtualization and infrastructure modernization solutions. Partners with account executives, engages customers, leads architecture discussions, presents solutions, advises on virtualization and migration strategies, develops service scopes, and supports pricing and delivery alignment. Requires deep virtualization architecture experience across VMware or related platforms, cloud, containers, security, AI, and infrastructure modernization.

Administer and optimize SQL Server databases while designing normalized schemas, mapping XML data, and developing SSIS-based ETL and migration pipelines. Responsibilities include database maintenance, backup and recovery, performance tuning, security controls, audit logging, testing, production cutovers, rollback planning, and ongoing migration support. The role also requires collaboration across development, testing, systems engineering, and business teams.

Oversee and finalize legal documents governing data sharing between Healthcare Fraud Prevention Partnership members and a trusted third party. Collaborate with CMS, HFPP leadership, partner engagement teams, and private payer partners on agreements, compliance, and negotiations. Present to management, support partner relationships, and ensure legal requirements are met for data governance and sharing.

Lead administration of Microsoft 365, Google Workspace, SaaS applications, Azure identity, and cloud infrastructure in a fully cloud-based organization. Provide Level 2/3 service desk escalation, execute migrations and cybersecurity projects, establish IT service processes, manage assets and vendors, and support onboarding, offboarding, incident response, change management, and M&A initiatives. The role partners with IT leadership and may help build and manage a growing internal technical team.

The Senior Clinical Trials IT Business Analyst bridges Clinical Development and IT, optimizing clinical trial technologies and managing system implementations, validations, and stakeholder engagement.

Lead human-centered design and front-end engineering for the NIH Data Lakehouse: conduct user research and testing; create wireframes, prototypes, flows, and accessible interfaces; build scalable React/Next.js/TypeScript UI components; integrate with GraphQL and search services; contribute to design systems, component libraries, and platform-wide front-end best practices.

Oversee multiple enterprise IT programs and projects for the CIDO organization. Responsibilities include managing schedules, budgets, risks, dependencies, staffing, requirements, testing, training, deployment, and change management. The role coordinates business and IT teams, facilitates stakeholder workshops, prepares executive dashboards, supports acquisition and delivery of IT solutions, and aligns digital strategies across corporate, sector, and functional leadership.

Leads enterprise architecture for Biogen’s Veeva ecosystem across Development, Quality, Regulatory, Safety, and Commercial functions. Translates business needs into scalable Veeva configurations and integrations, governs target-state architecture and platform standards, reviews solution designs, and oversees implementation and release planning. Mentors configuration teams, drives cross-vault consistency, manages architecture governance, aligns with Veeva product roadmaps, and advises IT leadership on platform strategy, investments, regulatory compliance, and business objectives.