Top Senior Machine Learning Jobs in Columbus, OH

Staff Software Engineer responsible for setting technical direction, architecting scalable distributed systems, shipping high-impact features, and building AI-powered tools for a virtual healthcare platform. The role includes mentoring engineers, partnering with product and clinical leadership, translating user needs into technical solutions, and guiding frontend and backend application development in a fast-paced startup environment.

Leads enterprise evaluation, governance, and implementation planning for emerging mental health therapeutics, including digital therapeutics, AI-enabled tools, neuromodulation, pharmacotherapies, and technology-enabled care models. Develops clinical protocols, workflows, provider training, safety criteria, outcome measurement, and adoption support. Partners with clinical, technology, research, quality, operations, and growth teams; evaluates vendors and evidence; monitors regulatory developments; and advances responsible innovation across the organization.

Lead the roadmap and delivery of an AI-native L1 IT operations agent. Partner with customers, design partners, engineering, and go-to-market teams to ship enterprise-scale capabilities, improve self-service adoption, and build trust through transparent agent experiences and feedback loops. Drive product strategy from discovery through launch in a fast-paced, ambiguous environment.

Develop client AI/ML solution architectures, assess technical feasibility, define requirements, estimate work, identify risks, and prepare proposal content. Design deployable inference solutions across FPGA, adaptive SoC, GPU, and AI accelerator targets while evaluating latency, throughput, power, memory, data pipelines, and production requirements. Present solutions, support business development, contribute to product and R&D initiatives, and undertake project work. Travel within North America for up to six weeks annually.

Shape company-wide machine learning strategy across credit, fraud, marketing, and growth. Build and improve consumer credit models, establish model governance and responsible modeling controls, and advance experimentation, causal inference, and business measurement. Provide technical leadership, mentor scientists, evaluate AI-assisted workflows, and partner with Legal, Compliance, Risk, Engineering, Product, and Finance to support reliable, compliant, and impactful financial decision systems.

Lead the design, development, deployment, monitoring, and improvement of interconnected customer lifetime value models covering conversion, retention, premiums, and claim losses. Serve as a hands-on technical leader, guide modeling strategy, evaluate experiments and business impact, partner with engineering and business teams, support production ML systems, establish technical standards, and coach other data scientists.

Develop and validate machine learning models, training pipelines, inference systems, and numerical methods using Python. Debug algorithmic and system-level issues, optimize memory usage and performance, design systematic tests, and build reproducible workflows. Review challenging ML engineering tasks, use coding agents in development, document technical findings, and deliver high-quality work independently within deadlines.

Develop and deploy machine-learned interatomic potentials for PFAS substitution. Responsibilities include generating and curating first-principles training data, building reproducible cloud and HPC workflows, training and validating ML force fields, running molecular dynamics and quantum chemistry campaigns, predicting physical properties, extending models to condensed-phase and process chemistries, and communicating model uncertainty and domain limitations.

Lead design, development, and production deployment of ML and algorithmic solutions. Own end-to-end ML systems, support distributed production reliability, communicate tradeoffs, and apply generative AI, LLM fine-tuning, RAG, and agentic techniques to product problems.

Leads the AI product strategy and roadmap, extending governed Alteryx workflows and business logic into enterprise AI agents and LLM ecosystems. Owns the Faster, Better, Cheaper ROI narrative, benchmarks product performance, quantifies customer value, champions trustworthy AI through the VURA framework, and represents the product vision with customers, analysts, and external audiences.

Leads Dandelion Health’s AI developer business by building pipeline, closing clinical AI data and validation partnerships, recruiting developers into its marketplace, and achieving revenue targets. Develops commercial strategy, manages executive relationships, structures agreements, and collaborates with marketing, product, data, engineering, and clinical informatics teams. Represents the company at industry events and advises on clinical AI validation, regulatory, payer, and competitive dynamics.

Researches, develops, tests, and maintains materials-aware machine learning models and software. Designs scalable ML systems, improves model interpretability and uncertainty quantification, and develops inverse-design capabilities. Collaborates with product, engineering, and external research teams to deliver customer-focused AI solutions, publishes research, reviews code, analyzes model performance, and mentors developers.

Develop and deploy machine learning algorithms that improve real-time device identification and fraud detection. Own data science projects from experimentation through production, including supervised, semi-supervised, and unsupervised learning, real-time inference, training automation, exploratory analysis, and model-to-service integration. Contribute to engineering best practices, collaborate within a global remote team, and participate in a shared on-call rotation.

Improve 1Password’s technical SEO across consumer, PLG, and enterprise websites. Responsibilities include diagnosing and resolving crawlability, indexing, rendering, performance, structured data, internal linking, and international SEO issues; implementing CMS changes; partnering with engineering on requirements and release QA; leading migration workstreams; and building monitoring, dashboards, automation, and repeatable processes using search, analytics, crawl, log, and CMS data.

Own the vision, strategy, roadmap, discovery, delivery, and continuous improvement of Rezilient’s member experience products. Partner with clinical operations, engineering, design, customer success, and sales to ship accessible, engaging healthcare experiences. Define requirements, prioritize backlogs, establish product metrics, ensure healthcare compliance, and help integrate AI into care delivery. The role requires experience scaling consumer health products, building AI or machine learning features, and operating effectively in a regulated startup environment.

Own and grow strategic Financial Services accounts through executive relationship management, consultative selling, renewals, and expansion. Lead commercial strategy, SOWs, negotiations, QBRs, delivery governance, escalations, and value realization. Coordinate delivery, sales, solutions, cloud, and Databricks partners while managing scope, budgets, timelines, margins, retention, profitability, and customer satisfaction. Translate Databricks, data engineering, analytics, ML, AI, and cloud transformation capabilities into measurable business outcomes.

Lead data science projects from ideation through enterprise impact, building scalable and well-tested solutions that improve healthcare outcomes. Apply probability, statistics, machine learning, SQL, and Python to develop data-driven products and insights. Partner with stakeholders, assess product performance, identify strategic improvements, mitigate risks, and mentor teammates while aligning initiatives with business objectives.

Lead end-to-end product design for an AI-powered women’s health platform. Responsibilities include defining UX vision, creating interaction models, information architecture, wireframes, high-fidelity interfaces, prototypes, design systems, and user research. Collaborate with product, engineering, ML, marketing, and leadership teams to translate business needs into customer-focused solutions, manage design initiatives, and measure product success through user feedback and metrics.

Own the full lifecycle of production classification and detection models, including transformer fine-tuning, entity detection, behavioral risk scoring, training, serving, versioning, evaluation, drift detection, and retraining. Build SageMaker-based ML systems and define output contracts supporting audit and policy enforcement. Lead the evaluation harness and mentor a co-op while operating as the company’s sole ML engineer.

Own the analytics roadmap for a Consumer Banking customer pillar, leading measurement, experimentation, and analyses across growth, retention, pricing, servicing, and strategy. Translate complex business questions into executive-ready recommendations, influence cross-functional decisions, establish analytical standards, and mentor analytics talent. The role requires strong statistical, experimental, communication, visualization, and stakeholder-management skills.

Own the strategy, roadmap, and investment priorities for foundational agricultural data products, including pipelines, data models, APIs, and shared services. Partner with engineering, architecture, data science, and product teams to deliver scalable, governed, high-quality data capabilities. Prioritize initiatives based on customer and commercial value, define success metrics, resolve cross-team tradeoffs, and expand data support for analytics, predictive modeling, machine learning, and AI applications.

Sell Infoblox networking and security solutions to enterprise accounts in the Ohio territory. Own full sales cycle, hunt new logos, expand existing accounts, build pipeline, hit quota, collaborate with BDRs, solutions architects, and marketing, and leverage AI tools to enhance prospecting and demonstrate ROI to executive and technical stakeholders.

Lead end-to-end LLM inference performance across serving systems, models, GPU hardware, and workloads. Define rigorous benchmarks, diagnose bottlenecks from scheduling through kernels and interconnects, optimize single- and multi-node deployments, and deliver production-ready runtimes and configurations. Collaborate with product and infrastructure teams, evaluate inference technologies, and implement runtime fixes. The role requires strong Python engineering, production experience with serving engines such as vLLM or SGLang, GPU profiling, and knowledge of modern inference optimization techniques.

Lead UX design initiatives across a healthcare product suite, solving complex user and business problems through research, prototyping, interaction and visual design. Mentor designers, influence cross-functional teams, contribute to the design system, and establish scalable design standards. Collaborate with engineering, product, leadership, and data science teams to integrate ML features and deliver intuitive, consumer-quality healthcare experiences.

Lead UX design initiatives across a healthcare product suite, solving complex problems through prototyping, user research, and strategic design. Collaborate with engineering, product, leadership, and data science teams to create consumer-quality experiences, integrate ML features, and evolve scalable design systems. Mentor designers, resolve stakeholder feedback, establish design standards, and drive innovation across large-scale projects.