Top Senior Machine Learning Jobs in Charleston, SC

YesterdaySaved
Remote or Hybrid
Charleston, SC
Senior level
Senior level
Information Technology • Database • Consulting
Lead development of time-series and econometric models (ARIMA, VAR, state-space, WLS, panel data) and Bayesian probabilistic frameworks. Use causal inference and stochastic processes to produce actionable insights, work with large datasets on Databricks, communicate results to stakeholders, and mentor junior team members.
Top Skills: A/B TestingArimaBayesian ModelingCausal InferenceDatabricksMachine LearningMarkov ChainsMlopsPanel Data ModelsPythonSarimaSQLState-Space ModelsStochastic ProcessesVarWls
YesterdaySaved
In-Office or Remote
Charleston, SC
Senior level
Senior level
Blockchain • Fintech • Software • Cryptocurrency • Metaverse
Design, develop, and maintain high-performance, secure Java backend services and APIs. Ensure reliability, scalability, and cost-efficiency across microservices, databases, messaging systems, and capacity planning. Troubleshoot, profile, benchmark, and optimize systems (including ML applications) and collaborate with Kazakhstan stakeholders.
Top Skills: Apache (Open-Source Projects)BenchmarkingJavaKafkaLinuxMachine LearningMicroservicesNoSQLProfilingRabbitMQRestful ApisSpring BootSQL
YesterdaySaved
Remote
Charleston, SC
Senior level
Senior level
Agency • Information Technology
Design and implement conversational AI solutions using NLP, ML, and LLMs. Build ETL pipelines and integrate relational and NoSQL databases. Develop Voice AI interactions on Vertex AI, work with Nuance IVR and Microsoft platforms, and write production-grade Python code.
Top Skills: BertETLGenaiGptMachine LearningMicrosoftMongoDBNlpNoSQLNuance IvrPythonRelational DatabasesVertex AiVoice Ai
YesterdaySaved
In-Office or Remote
Charleston, SC
56K-196K Annually
Senior level
56K-196K Annually
Senior level
Agency • Information Technology
Lead design, implementation, and scaling of enterprise Palantir data solutions. Oversee cross-functional teams to build data pipelines, integrations, governance, and advanced analytics (ML/AI). Manage project delivery, stakeholder engagement, performance optimization, and mentor senior engineers and analysts while ensuring security and regulatory compliance.
Top Skills: AIAWSAzureEltETLGCPMachine LearningPalantir FoundryPalantir GothamPythonSQL
YesterdaySaved
Remote
Charleston, SC
35K-125K Annually
Senior level
35K-125K Annually
Senior level
Agency • Information Technology
Gather and document functional requirements for agent-facing servicing applications, define integrations/APIs with core banking systems, consult with stakeholders, identify AI/ML opportunities (fraud, KYC, automation), support testing and implementation, and act as SME while managing risks and compliance.
Top Skills: AgileAIAPIsCore Banking SystemsFraud Detection SystemsKyc SystemsMachine Learning
YesterdaySaved
In-Office or Remote
Charleston, SC
38K-133K Annually
Senior level
38K-133K Annually
Senior level
Agency • Information Technology
Senior Business Systems Analyst to define requirements for agent-facing servicing applications, design integrations/APIs with core banking systems, translate needs into user stories and acceptance criteria, improve agent workflows and productivity, and identify AI/ML opportunities for fraud detection, automation, and operational analytics. Supports testing, validation, and releases.
Top Skills: AIAPIsMachine Learning
YesterdaySaved
Remote
Charleston, SC
130K-140K Annually
Senior level
130K-140K Annually
Senior level
Cloud • Information Technology • Consulting
Lead procurement strategy and supplier selection for inbound products and services. Manage RFIs/RFPs, negotiate contracts with Legal, administer Coupa purchase orders, reconcile invoices, and apply AI/ML and reporting tools to optimize procurement processes while collaborating with cross-functional senior stakeholders.
Top Skills: AIAtlassianCoupaMachine LearningExcelMicrosoft OutlookMicrosoft PowerpointMicrosoft WordPower BIServicenow
YesterdaySaved
Remote
Charleston, SC
Senior level
Senior level
Gaming • Machine Learning • News + Entertainment • Design • Conversational AI • Generative AI
Lead technical execution across backend, frontend, mobile, AI, and data. Translate ambiguous product goals into technical plans, unblock hard engineering problems, coordinate cross-domain work, raise engineering quality, define hiring needs and technical evaluation standards, and build internal AI workflows to foster an AI-native engineering culture.
Top Skills: Ai AgentsAi SystemsAndroidData InfrastructureData PipelinesExperimentationFlutterGoiOSLlm WorkflowsMachine LearningNext.JsPythonReactReact NativeRecommendation Systems
2 Days AgoSaved
Remote
Charleston, SC
134K-210K Annually
Senior level
134K-210K Annually
Senior level
Software
Lead and deliver complex, cross-team AI product programs, drive agent-first SDLC adoption, ensure integration and operational readiness of AI workflows, define metrics, communicate risks and status, and standardize TPM best practices across Product and Engineering.
Top Skills: Agentic AiAWSAzureBitbucketData PipelinesGitJenkinsMachine LearningModel LifecycleTelemetry
2 Days AgoSaved
Remote
Charleston, SC
Senior level
Senior level
Information Technology • Consulting
Design, develop, and implement secure, scalable cloud systems (Azure/AWS); perform system engineering, risk assessments, and NIST-compliant ATO/ATD processes; manage secure data ingestion and orchestration; integrate AI/ML concepts; secure communications and network infrastructure; present technical findings to senior USG leadership and provide hands-on support.
Top Skills: AIAuthority To Operate (Ato)Authorization To Deploy (Atd)AWSAzureMachine LearningNistPythonWindows Powershell
2 Days AgoSaved
Remote
Charleston, SC
150K-240K Annually
Senior level
150K-240K Annually
Senior level
Healthtech • Software
Lead end-to-end healthcare fraud investigations for Clover's Medicare Advantage business. Own caseloads, gather and analyze claims and medical evidence, coordinate legal support, prepare defensible referral packages, leverage AI and analytics tools, and collaborate cross-functionally to drive recoveries and provider actions.
Top Skills: AIAutomationData AnalyticsData VisualizationMachine LearningPredictive Analytics
2 Days AgoSaved
Remote or Hybrid
Charleston, SC
175K-195K Annually
Senior level
175K-195K Annually
Senior level
Big Data • Cloud • Security • Software • Cybersecurity
Lead architecture and implementation of high-performance software to deploy and operate AI/ML models for network threat detection. Build autonomous AI agent workflows, production ML pipelines, and services; drive cross-team engineering standards, mentor engineers, and represent technical direction to leadership.
Top Skills: AIAutonomous Ai AgentsAWSAzureDockerGoIntrusion Detection Systems (Ids)KubernetesMachine LearningNetwork Detection And Response (Ndr)Network TelemetryPython
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2 Days AgoSaved
Remote
Charleston, SC
148K-185K Annually
Senior level
148K-185K Annually
Senior level
Consumer Web • Digital Media • Information Technology • Music • Software
Own growth and performance for Kits AI across funnel optimization, activation, retention, pricing, and monetization. Productize ML capabilities into creator-facing workflows, partner with research and engineering, run experiments and analytics (e.g., Amplitude), conduct customer research, and leverage AI tools to accelerate shipping and internal insight systems.
Top Skills: AIAi Coding ToolsAmplitudeAudio PluginsDigital Audio Workstation (Daw)Machine Learning
2 Days AgoSaved
Remote
Charleston, SC
60-90 Hourly
Senior level
60-90 Hourly
Senior level
Artificial Intelligence • HR Tech • Professional Services • Software
Evaluate and strengthen AI model behavior on cybersecurity topics by writing expert prompts, annotating and grading model responses for accuracy and safety, and applying structured guidelines to classify sensitive content. Work part-time on AI safety tasks with emphasis on secure, responsible handling of dual-use information.
Top Skills: AICybersecurityMachine LearningPrompt Engineering
Reposted 7 Days AgoSaved
Remote
Charleston, SC
160K-220K Annually
Senior level
160K-220K Annually
Senior level
Artificial Intelligence • Machine Learning • Natural Language Processing • Software • Conversational AI
As an ML Ops Infrastructure Engineer, you will design CI/CD pipelines for ML, maintain deployment systems, and implement monitoring while collaborating with research teams to ensure model quality and performance.
Top Skills: Ci/CdDatadogDockerGrafanaKubernetesNvidia Triton Inference ServerOnnx RuntimePrometheusPulumiPythonTensorrtTerraform
Reposted 7 Days AgoSaved
Remote
Charleston, SC
160K-220K Annually
Senior level
160K-220K Annually
Senior level
Artificial Intelligence • Machine Learning • Natural Language Processing • Software • Conversational AI
As a Systems Architect, you'll define and drive the infrastructure architecture for AI/ML workloads, design multi-cloud strategies, manage compute orchestration and storage systems, and lead capacity planning, while also collaborating with engineering leadership.
Top Skills: AIAWSCloud ServicesContainer OrchestrationGpu InfrastructureKubernetesMlStorage Systems
Reposted 7 Days AgoSaved
Remote
Charleston, SC
150K-220K Annually
Senior level
150K-220K Annually
Senior level
Artificial Intelligence • Machine Learning • Natural Language Processing • Software • Conversational AI
The engineer will build and operate AI/ML infrastructure, managing services on AWS and bare metal, using tools like Kubernetes and Terraform.
Top Skills: AWSBashGoKubernetesPythonSlurmTerraform
2 Days AgoSaved
Remote
Charleston, SC
141K-173K Annually
Senior level
141K-173K Annually
Senior level
Fintech • Payments
Design, develop, test, and deploy RPA/AI agent solutions (UiPath/Blue Prism) integrated with enterprise systems. Analyze business processes, estimate feasibility, create maintainable automation workflows, document solutions, support UAT/rollout, and troubleshoot production automations. Collaborate with stakeholders, manage integrations (APIs/SQL/WebServices), and ensure quality using unit testing and source control.
Top Skills: .NetAPIsAws AgentcoreAws BedrockAzure OcrBlue PrismBpmCommunications MiningGitIxpJIRAJob Scheduling SoftwareMachine LearningMaestroNlpOcrPythonRpaRpa DesignerSQLSubversionUipathUipath Case ManagementWebhooksWebservices
Reposted 2 Days AgoSaved
In-Office or Remote
Charleston, SC
125K-175K Annually
Senior level
125K-175K Annually
Senior level
Insurance
The AVP, Digital Portfolio Management oversees P&L for small business products, driving underwriting profitability and digital transformation through analytics, cross-functional collaboration, and strategic initiatives.
Top Skills: Data AnalyticsMachine LearningPower BIQlik
Reposted 2 Days AgoSaved
Remote
Charleston, SC
Senior level
Senior level
Big Data • Analytics • Business Intelligence • Big Data Analytics
The Senior Data Scientist will design and deploy time-series forecasting models, collaborate with stakeholders, and operationalize models in cloud environments, focusing on demand planning across various industries.
Top Skills: AIArimaAzureData ScienceDemand ForecastingEtsGbmLightgbmMachine LearningPythonRandom ForestSarimaSQLTime-Series ModelingXgboost
Reposted 2 Days AgoSaved
Remote
Charleston, SC
100K-100K Annually
Senior level
100K-100K Annually
Senior level
Artificial Intelligence • Machine Learning • Database
Seeking a Senior Full Stack .NET Developer to work on a social good project, with strong skills in C#, AngularJS, design, and UX. Requires 5+ years of experience.
Top Skills: .NetAngularAngularjsC#Machine LearningPython
Reposted 2 Days AgoSaved
Remote
Charleston, SC
141K-176K Annually
Senior level
141K-176K Annually
Senior level
Biotech
Lead the strategy and execution of AI and data products, focusing on sales and marketing initiatives while partnering with business teams to define and deliver impactful solutions across operational systems.
Top Skills: AIAirflowAWSDagsterData SystemsDbtMachine LearningModern Data PlatformsSagemakerSalesforceSnowflake
Reposted 2 Days AgoSaved
Remote
Charleston, SC
127K-212K Annually
Senior level
127K-212K Annually
Senior level
Fashion
Lead the design strategy for client and stylist experiences at Stitch Fix, incorporating AI, managing a design team, and driving product evolution.
Top Skills: AIDesign SoftwareMachine Learning
3 Days AgoSaved
Remote
Charleston, SC
96K-164K Annually
Senior level
96K-164K Annually
Senior level
Financial Services
Build and scale a greenfield digital lending platform with emphasis on front-end experience, cloud-native infrastructure, AI/ML integration, ServiceNow implementations, and mobile/web applications. Work across the full SDLC as a hands-on senior individual contributor, collaborate with product and design, perform code reviews, support QA and production, and integrate with partners and enterprise systems.
Top Skills: AICloud-NativeGitMachine LearningMobile ApplicationsServicenowSubversionWeb Applications
3 Days AgoSaved
Remote
Charleston, SC
85K-135K Annually
Senior level
85K-135K Annually
Senior level
Financial Services
Build, configure, support, and maintain a new digital lending ecosystem. Gather and document requirements, perform system administration, integrations, data migrations, testing, and collaborate with vendors and stakeholders to implement cloud-native, AI/ML-enabled underwriting and enterprise application solutions.
Top Skills: AICloud-NativeMachine LearningMicrosoft AccessExcelMicrosoft PowerpointMicrosoft Sql ServerMicrosoft VisioMicrosoft WordOracleStreamline Capital
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