Top Senior Python Jobs in Wilmington, NC

Reposted 20 Hours AgoSaved
Remote
Wilmington, NC
Senior level
Senior level
Artificial Intelligence • Information Technology • Professional Services • Software
The Senior Full Stack Developer will design, develop, test, and debug software solutions, collaborating with teams and optimizing applications. Responsibilities include user interaction design, back-end functionality, and ensuring software scalability and security.
Top Skills: CSSDjangoDockerFastapiFlaskGitGnu/LinuxHTMLJavaScriptMongoDBMySQLNode.jsOraclePostgresPythonReactSvnVue
Reposted 2 Days AgoSaved
Remote
Wilmington, NC
Senior level
Senior level
Logistics • Software • Transportation
The Principal Python Engineer will design, build, and maintain backend services and APIs, focusing on system reliability and engineering quality. The role involves working with databases, applying DevOps practices, and leveraging AI for development efficiency.
Top Skills: DockerFastapiKubernetesPostgresPulumiPythonTemporalVue
Reposted 2 Days AgoSaved
In-Office or Remote
Wilmington, NC
Senior level
Senior level
Cloud • Software
The Python Engineer will write maintainable Python software, lead technical initiatives, collaborate globally, and contribute to community engagement at Canonical.
Top Skills: CC++DockerGoKubernetesLinuxNoSQLPythonRustSQL
Reposted 16 Days AgoSaved
Easy Apply
Remote or Hybrid
Wilmington, NC
Easy Apply
126K-248K Annually
Senior level
126K-248K Annually
Senior level
Big Data • Cloud • Software • Database
The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.
Top Skills: Ai/Ml FrameworksMongoDBPypiPython
21 Days AgoSaved
Remote
Wilmington, NC
1M-2M Annually
Senior level
1M-2M Annually
Senior level
Agency • Information Technology • Software • App development
Design, develop, and maintain scalable Python applications and cloud-native solutions. Architect microservices, containerized deployments (Docker/Kubernetes), optimize cloud infrastructure, build CI/CD pipelines, integrate messaging systems, ensure security and high code quality, and mentor junior developers. Generative AI/ML experience is a plus.
Top Skills: AWSAzureAzure PipelinesCi/CdCosmosdbDjangoDockerFastapiFlaskGenerative AiGitlab CiGCPHugging FaceJenkinsKafkaKubernetesPythonPyTorchRabbitMQRdsRest ApisServerlessTensorFlowWebsockets
Reposted 20 Hours AgoSaved
In-Office or Remote
Wilmington, NC
135K-155K Annually
Senior level
135K-155K Annually
Senior level
Machine Learning • Other
The Backend Software Engineer will develop and maintain backend systems for data processing related to coffee farming, utilizing Python and PostgreSQL. Responsibilities include feature development, problem-solving, and adapting systems to regulatory changes while ensuring system resilience.
Top Skills: AWSCi/CdDockerPostgresPostgresql/PostgisPythonTerraform
Reposted YesterdaySaved
Remote
Wilmington, NC
Senior level
Senior level
Healthtech • Software
Lead and code fullstack features for the EVV team, provide technical leadership and mentoring, design and execute automated tests, monitor and troubleshoot production, contribute to product technical roadmap, and leverage AI-assisted development tools.
Top Skills: AWSCi/CdClaudeCursorDockerGitJavaScriptPHPPytestPythonSQLSqlalchemyVue
Reposted YesterdaySaved
Remote
Wilmington, NC
Senior level
Senior level
Software
Lead the design and development of scalable Python backend services and APIs on AWS, mentor engineers, and manage PostgreSQL databases in a healthcare technology environment.
Top Skills: Api GatewayAWSBitbucketDockerGitJIRAKubernetesLambdaOauth 2PostgresPythonRest ApiSlackTeams
2 Days AgoSaved
Remote
Wilmington, NC
Senior level
Senior level
Artificial Intelligence • Information Technology • Machine Learning • Software • Analytics • Consulting • Financial Services
Develop, test, and maintain a complex distributed processing application using Python and Java. Collaborate with product owners, data coaches, analysts, DBAs, and Agile teams to meet backend/frontend requirements. Work with distributed workloads (Spark/Hadoop), SQL/Snowflake, AWS, shell scripting, and job scheduling/process automation. Support delivery under Agile/SAFe practices and ensure alignment with program standards.
Top Skills: AWSBash/Shell ScriptingDroolsHadoopJavaLinux (Cli)OdmPythonSnowflakeSparkSQLVs Code
2 Days AgoSaved
Remote
Wilmington, NC
Senior level
Senior level
Artificial Intelligence • Information Technology • Machine Learning • Software • Analytics • Consulting • Financial Services
Lead Software Engineer responsible for designing, developing, testing, and maintaining a distributed processing application using Python and Java. Collaborate with product owners, data coaches, analysts, DBAs, and Agile teams to meet backend/frontend requirements, implement cloud and big-data solutions (Spark/Hadoop), and ensure program standards and reliable delivery.
Top Skills: SparkAWSDroolsHadoopIbm OdmJavaLinuxPythonShell ScriptingSnowflakeSQLVisual StudioVs Code
Reposted 2 Days AgoSaved
Remote
Wilmington, NC
Senior level
Senior level
Healthtech • Software
Lead backend development on the scheduling platform modernization, contribute across products, write APIs, and drive AI-accelerated software development workflows.
Top Skills: .NetAgent OrchestrationAi-Assisted DevelopmentLlm ToolingPython
Reposted 2 Days AgoSaved
Remote
Wilmington, NC
Senior level
Senior level
Healthtech • Software
Lead backend development on the scheduling platform modernization. Contribute across Python and .NET ecosystems, write APIs, review code, and support AI-accelerated development workflows while collaborating in a remote team environment.
Top Skills: .NetAi-Assisted Development WorkflowsClaude CodeLlm ToolingMulti-Agent SystemsPython
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Reposted 2 Days AgoSaved
Remote
Wilmington, NC
180K-190K Annually
Senior level
180K-190K Annually
Senior level
Artificial Intelligence • Food • Software
The Senior Full Stack Engineer will develop scalable web applications using Python and React.js, mentor team members, and enhance system performance while leveraging AI technologies. The role emphasizes collaboration, end-to-end feature ownership, and architectural improvements in a remote setting.
Top Skills: AWSCi/CdClaude CodeCodexDatadogDockerGithub ActionsGraphQLMySQLNew RelicPostgresPythonReactRestful ApisSentrySQL
Reposted 2 Days AgoSaved
Remote
Wilmington, NC
4K-5K Hourly
Senior level
4K-5K Hourly
Senior level
Travel
Lead development of Python-based web applications using Django and FastAPI, architect scalable solutions, and establish technical standards while mentoring developers and optimizing infrastructure.
Top Skills: Ai Coding AssistantsAWSDjangoFastapiGitPostgresPythonRailway
Reposted 2 Days AgoSaved
In-Office or Remote
Wilmington, NC
Senior level
Senior level
Digital Media
Develop and enhance features for EnrollWise, contribute to a scalable software architecture, review code, collaborate on design and technical feasibility, and maintain software quality.
Top Skills: ApolloAWSDjangoDjango OrmGraphQLNextjsPythonReact
8 Days AgoSaved
Remote or Hybrid
Wilmington, NC
Senior level
Senior level
Digital Media • Social Media • Software • Design
Design, develop, and maintain scalable Python applications; collaborate with cross-functional teams to deliver features; ensure performance and quality; identify and fix bugs; maintain code quality and automation; lead and mentor team members using agile practices.
Top Skills: Python
8 Days AgoSaved
In-Office or Remote
Wilmington, NC
Senior level
Senior level
Agency • Information Technology
Design, build, test, and maintain backend applications using FastAPI and SQLAlchemy. Implement database schemas, integrate front-end components, optimize for performance and scalability, debug issues, participate in code reviews, and collaborate on feature design. Maintain clean, testable code and stay current with best practices.
Top Skills: FastapiGitMySQLOraclePytestPythonSQLSqlalchemy
Reposted 11 Days AgoSaved
Remote
Wilmington, NC
165K-215K Annually
Senior level
165K-215K Annually
Senior level
Legal Tech • Software
Design and implement durable, fault-tolerant AI orchestration and backend systems using Temporal and agentic ReAct patterns. Deliver features end-to-end with testing, CI/CD, monitoring, and observability; mentor engineers and collaborate with cross-functional teams to translate legal workflows into reliable AI-powered features.
Top Skills: Async/AwaitClaude (Llm)Event-Driven ArchitectureFastapiGitlab Ci/CdMessage QueuesNew Relic ApmOctopus DeployPlaywrightPydantic V2Pydantic-AiPytestPython 3.12+ReactStructlogSyrupyTemporal
Reposted 11 Days AgoSaved
Remote
Wilmington, NC
200K-225K Annually
Senior level
200K-225K Annually
Senior level
Artificial Intelligence • eCommerce • Software
Design and build backend systems and APIs for AI-driven products, ensuring scalability, reliability, and integration of ML models while collaborating with engineering and product teams.
Top Skills: APIsAWSAzureDockerGCPKubernetesLlmsMachine LearningNoSQLPythonSQL
Reposted 11 Days AgoSaved
Remote
Wilmington, NC
90-110 Annually
Senior level
90-110 Annually
Senior level
Digital Media • Professional Services • Consulting • Financial Services
The Senior Python Developer will enhance commerce and communication infrastructure by developing features, collaborating with stakeholders, ensuring system reliability, and integrating with third-party tools, while maintaining high-performance standards.
Top Skills: Ci/CdDockerFastapiPostgresPythonRabbitMQRedisStripe
Reposted 13 Days AgoSaved
Remote
Wilmington, NC
100K-200K Annually
Senior level
100K-200K Annually
Senior level
Artificial Intelligence • HR Tech • Information Technology • Software
As a Founding Staff Software Engineer, you will lead the design and development of robust backend systems and APIs, optimize large-scale data workflows, and mentor a growing engineering team.
Top Skills: AWSCeleryFastapiOpensearchPostgresPythonRedisTemporal
Reposted 15 Days AgoSaved
Remote
Wilmington, NC
125K-200K Annually
Senior level
125K-200K Annually
Senior level
Software • Cybersecurity
The Forward Deployed Engineer will serve as a technical bridge between clients and engineering teams, writing custom code and integrations, while ensuring customer success with Socket's security platform through strong relationships and expert technical guidance.
Top Skills: Automation ScriptsCi/CdDevOpsPythonSastWebhook Implementations
Reposted 15 Days AgoSaved
Remote
Wilmington, NC
Senior level
Senior level
Financial Services
As a Senior Python Engineer, you'll manage and optimize investment data solutions, collaborate on design, and develop scalable data applications using emerging tools and best practices.
Top Skills: AirflowAnsibleDockerElastic StackKafkaOauth2OktaPlainidPostgresPythonRabbitMQRedisRestful ApisSQL
16 Days AgoSaved
Remote
Wilmington, NC
Senior level
Senior level
Artificial Intelligence • Logistics • Software • Transportation
Design, develop, deploy, monitor, and support APIs and system integrations (Salesforce, REST, third-party). Work directly with clients to gather requirements, troubleshoot and optimize integrations, operate solutions in AWS, collaborate with teams, and mentor junior developers.
Top Skills: Aws Api GatewayAws EcsAws LambdaAws RdsPythonRest ApiSalesforceSnsSqsTerraform
16 Days AgoSaved
Remote
Wilmington, NC
Senior level
Senior level
Information Technology • Logistics • Transportation • Consulting
Build and ship full‑stack features for transportation management and other client products. Design and implement APIs and UIs, collaborate with product and design, own delivery, write modular testable code, troubleshoot and iterate quickly, and mentor peers.
Top Skills: .NetC#Ci/CdDevOpsDockerElectronFastapiGraphQLJavaJavaScriptLlmsLookmlMlMongoDBMySQLNode.jsPythonReact NativeReactRestSpringTypescriptVue
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