Top Remote Software Engineer Jobs in St. Louis, MO

Lead end-to-end feature development across frontend and backend for an enterprise data analytics platform. Design, implement, and maintain React UIs, backend services, APIs, databases, and distributed systems. Collaborate with Product, UX, and Engineering, mentor engineers, improve quality through testing/CI, and introduce new technologies including AI-assisted development.

Design and implement scalable backend and frontend systems, build and maintain data pipelines, design SQL/GraphQL database systems, collaborate on product and metrics, improve performance, security, and reliability, and support customer-facing features.

Design and own CI/CD and configuration management for a large-scale, multi-cluster Kubernetes fleet. Define GitOps-driven, declarative reference architectures and templated production environments. Implement progressive delivery (canary, automated rollback), improve pipeline reliability and speed, evolve the Internal Developer Portal, embed AI tooling into delivery workflows, and partner with Cloud, Security, and Compliance while mentoring senior engineers.

Designs and develops software to automate onboarding, validation, management, tracking, and lifecycle operations for new hardware deployed in Microsoft datacenters. Responsibilities include requirements analysis, system design, coding, debugging, optimization, reliability engineering, monitoring, on-call support, and incident response. The role collaborates with Azure teams and stakeholders while improving scalability, security, availability, observability, and performance across cloud and distributed systems.

Design and implement PostgreSQL internals, indexing, query engine extensions, and storage-layer features to support large-scale document workloads on Azure. Profile distributed systems, tune performance, collaborate with open-source communities, conduct design/code reviews, and drive cross-team alignment for mission-critical database features.

Build and maintain on-chain smart contracts and backend services for branded USDC-backed stablecoins. Own issuance, reserves, mint/burn, and rewards systems; drive architecture, security, and operational excellence; ship features with product and design partners and ensure well-tested, auditable production deployments.

Own quality engineering for high-throughput payment systems by architecting automated regression, performance, stress, and load testing. Build emulators for external payment systems, integrate quality gates into CI/CD pipelines, validate microservices, event-driven architectures, and databases, and use Prometheus and Grafana for observability. Apply AI-assisted testing, synthetic data generation, and edge-case analysis while mentoring engineers and preventing incidents through telemetry-driven testing and post-mortems.

Principal Software Engineer responsible for expert-level coding, system architecture, technical strategy, code quality, SDLC improvement, and enterprise-scale modernization. Designs distributed systems and API integrations, governs architectural change, drives resiliency, security, observability, and performance standards, and influences stakeholders across multiple teams. Mentors engineers, leads technical initiatives without direct authority, manages technical risks and dependencies, and ensures compliance with regulatory, audit, and corporate engineering standards.

Build and scale ML-optimized HPC infrastructure, manage Kubernetes-based GPU/TPU superclusters, optimize for AI/ML training, and mentor teams while innovating in ML infrastructure.

Build and maintain reliable, secure, scalable backend systems for Lithic’s product platform. Own projects end to end across API key management, reliability, audit logging, search, and API infrastructure. Improve system reliability, reduce technical debt, participate in on-call rotations, and lead team process improvements while collaborating asynchronously across time zones.

Build and operate highly scalable storage infrastructure supporting petabyte-scale imagery data. Responsibilities include developing backend services and APIs, managing object storage and metadata indexing, tuning Elasticsearch, improving disaster recovery, monitoring performance, responding to incidents, contributing to architecture and roadmaps, and advising engineers. The role requires strong production software engineering experience with Go or Python, cloud-native systems, relational and non-relational databases, and highly available services.

Build and deploy integrations between the Bayesian platform and large EHR systems, implement automated integration and end-to-end tests, support production deployments and go-lives, develop tooling and automation (including LLMs), and collaborate with implementation and clinical teams to deliver clinician-facing workflows.

Lead technical strategy and architecture for Affirm Bank's cloud, data, vendor integrations, and operational tooling. Design, build, and operate high-stakes systems end-to-end, own incident response, vendor selection, and the Bank↔Affirm Inc integration boundary. Ensure examiner-ready documentation, compliance, reliability, and observability while mentoring engineers and pushing AI-assisted engineering practices to increase velocity and product safety.

Design and implement core payment infrastructure including workflow engines, partner integrations, ledgering systems, and public APIs. Make architectural decisions with leadership, own projects end-to-end, and help shape engineering culture and technical practices at an early-stage fintech.

As a Staff Frontend Software Engineer, you'll lead the frontend architecture using React and TypeScript, manage code releases, and integrate AI tools to enhance efficiency while ensuring high performance and system reliability.

Build and improve frontend interfaces for DogByte and other internal products used by veterinary hospitals. Own projects from problem framing through production release, collaborate with Design and Product, uphold accessibility and performance standards, evolve shared components and design systems, review technical work, and contribute to backend or full-stack development as needed. Apply AI tools thoughtfully across development workflows while maintaining quality and reliability.

Lead architecture and implementation of software for autonomous UAS systems; mentor engineers; ensure compliance with aerospace standards; optimize CI/CD pipelines.

Develop and enhance the new Stores platform while supporting various e-commerce tools to improve seller success online.

As a Software Engineer at Realm, you will develop backend services, create web and mobile UIs, and deploy tech at industrial sites. You will solve real-world challenges using various technologies and work with top leadership to build a stellar engineering team.

As a Front-End Engineer, you'll create intuitive UIs for AI tools, collaborating with design and backend teams, focusing on performance and user experience.

As a Senior Fullstack Software Engineer at Vanta, you will lead complex projects, set technical direction, design and develop new functionalities, and contribute to the engineering culture while mentoring other engineers.

The Software Engineer will develop and support the MEMX Trading system, focusing on high throughput event-sourcing applications and resolving production issues.

The role involves designing authentication and authorization solutions, integrating applications with identity platforms, and maintaining security practices within identity services. A focus on collaboration with Security and Product teams is important.

As a Software Engineer III, you'll develop custom software for government clients, teaching Agile practices, delivering software solutions, and ensuring client satisfaction through collaboration and feedback.

Seeking experienced Senior Backend Engineers to join a collaborative team, focusing on backend systems, shared services, and product features aimed at improving user experiences and monetization.