Top Remote Python Jobs in Houston, TX

Lead design and prototyping of generative AI experiences for autonomy development; drive UX for Hivemind products; perform user research, collaborate with CTO and product leads, and deliver reference implementations and integrations across full-stack web and edge systems.

Design and implement full‑stack, low‑latency web-based Ground Control Station and C2 systems (map-centric UIs, real-time telemetry, video streaming), lead architecture and APIs, mentor engineers, support field tests and mission deployments, and ensure interoperability with C2 standards.

As a Pre-Sales Solutions Engineer, you will drive technical pre-sales engagements, architect custom solutions, and guide customers on API integration and deployment strategies, enhancing their experience with Voice AI technologies.

Design and implement secure, scalable backend services for speech inference and audio processing. Optimize networking, transcoding, latency, memory, and distributed compute orchestration. Measure and improve system performance, debug complex networking/scheduling/HPC issues, customize services for customers, and partner with Product to deliver features end-to-end.

Lead end-to-end technical integrations with enterprise healthcare customers from pre-sales through production. Scope and deliver architecture, POCs, API integrations, data mappings, and runbooks. Ensure AI/ML features meet regulatory and clinical safety standards, build reusable integration patterns, collaborate cross-functionally, and mentor junior engineers to drive successful go-lives.

Design and build end-to-end web and AI-powered dashboard features, scale cross-platform full-stack infrastructure, standardize product patterns, mentor engineers, lead cross-team technical projects, and collaborate with product and design to improve user workflows and AI adoption.

As a Senior Site Reliability Engineer, you'll design and build complex systems, support Atlas platform operations, automate processes, and ensure high availability of services.

Own technically complex, mission-critical areas and define technical strategy for new products. Design and ship full‑stack, AI‑driven features end‑to‑end, build scalable data ingestion and API systems, partner with product/design/customer teams to translate ambiguous problems into measurable outcomes, mentor engineers, and raise engineering quality and standards across the organization.

Design, build, test, deploy, and operate reusable enterprise integrations using Workato and modern APIs. Partner with engineering teams, define data flows and security models, create custom connectors and integration templates, and ensure production observability, testing, documentation, and support. Translate partner needs into product requirements, support sales proofs of concept, evaluate agent integration patterns, and use AI coding tools while validating security, correctness, and maintainability.

Design, build, operate, and improve cloud infrastructure, deployment systems, observability, developer tooling, and distributed systems. Own infrastructure products end to end, manage systems with Terraform, support scalable AWS and Kubernetes environments, operate Redis/ElastiCache, participate in incident response, improve reliability and performance, and mentor engineers while collaborating across teams.

Owns production reliability for high-throughput, low-latency systems, including observability, SLOs, incident response, capacity planning, infrastructure as code, progressive delivery, chaos testing, and operational tooling. The role requires hands-on software and infrastructure engineering, production Redis/ElastiCache expertise, cloud infrastructure knowledge, security awareness, mentoring, and participation in on-call operations.

Build sample applications, proof-of-concept integrations, and developer tools connecting NICE CXone with partner platforms. Document integration patterns, troubleshoot API and authentication issues, support partner onboarding, and translate partner feedback into product and engineering requirements. The role requires software development experience, REST API integration expertise, web technology knowledge, strong debugging and problem-solving skills, and the ability to communicate with technical and non-technical partners.

Develop and modernize the open-source conda ecosystem, including conda, conda-build, and plugins. Responsibilities include designing and delivering features, improving performance and reliability, owning projects from requirements through release, collaborating with distributed internal teams and external maintainers, contributing through GitHub, and participating in Scrum ceremonies. The role also involves using AI-assisted tools while maintaining code quality and engaging the open-source community.

Develop scalable Java Spring Boot APIs, microservices, React-based interfaces, ETL pipelines, and SQL data solutions. Deploy workloads on AWS, optimize performance, implement monitoring and automation, and collaborate with product, frontend, data, and DevOps teams. The role also contributes to architecture, accessibility, reliability, and data-driven product improvements.

Build and operate full-stack, cloud-native applications for network automation and mission platforms using Python, Go, JavaScript, and TypeScript. Develop APIs, AI agents, generative user interfaces, integrations, and telemetry workflows. Contribute to CI/CD, Infrastructure as Code, containerized deployments, production troubleshooting, security, observability, and architecture. Collaborate across software, cloud, platform, product, and security teams in an ambiguous, mission-focused environment.

Leads complex network and infrastructure solution development from customer requirements through architecture, implementation, deployment, operations, and sustainment. Provides technical leadership, customer engagement, proposal support, solution presentations, team coordination, mentoring, risk management, and delivery accountability across enterprise, tactical, government, and commercial environments. Integrates networking, software, automation, cloud, cybersecurity, service management, and observability technologies while supporting classified and sensitive programs.

Leads and develops a team building growth-critical platforms, AI-driven tools, automations, and infrastructure. Collaborates with Product and Design, guides architecture and implementation, manages execution, improves team processes, and partners with engineering leaders. The manager remains hands-on, writing production-grade backend code, using AI tools, and promoting quality, reliability, accountability, and team autonomy across distributed teams.

Lead hands-on technical delivery for a cross-functional product engineering pod. Design and implement Angular frontends, Python APIs, and cloud-native services while guiding engineers through architecture, code reviews, testing, releases, and production troubleshooting. Translate product requirements into maintainable designs and vertical slices, establish quality and security standards, manage technical debt, and collaborate with Product, QA, BA, and DevSecOps teams. Experience in regulated life sciences, clinical technology, and standards such as CDISC or USDM is preferred.

Build and operate scalable backend services for connected devices, including device connectivity, telemetry ingestion, health monitoring, command and control, and data pipelines. Collaborate with firmware, mobile, and product teams on APIs and workflows. Use AWS, microservices, streaming systems, observability tools, and AI coding agents to deliver reliable features, participate in incident response, and improve automation and engineering practices.

Develop and maintain Medicare claims-processing software in a legacy mainframe environment using COBOL and related technologies. Responsibilities include coding, debugging, unit testing, requirements analysis, defect resolution, software installation, technical documentation, and Agile/Scrum collaboration. The developer will support DME contract operations, deliver moderate-complexity solutions, estimate tasks, and coordinate with team members, clients, vendors, and other organizations.

Build scalable data processing and exploration pipelines, ML infrastructure, and cloud-based applications. Write, test, instrument, and deploy software in Kubernetes environments while contributing to distributed systems and data-driven products. The role focuses on Python, big data technologies, containerization, and systems supporting marketplace intelligence.

Designs and operates production data infrastructure, ETL/ELT pipelines, APIs, containerized AWS services, and graph-based systems. Responsibilities include relational, document, and graph database architecture; data quality and lineage; CI/CD automation; and integration of blockchain, financial, and investigative data. Partners with R&D, data scientists, and investigations teams to deliver production software for federal and commercial clients.

Lead modernization of a 30-year-old Store Management System by reverse engineering EZC file-based platforms, migrating data and applications to PostgreSQL, and developing enterprise C/C++ software. Responsibilities include architecture, systems integration, APIs, ETL, performance optimization, troubleshooting, documentation, and maintaining business continuity. The role also applies AI-assisted development tools for code analysis, documentation, testing, and modernization while mentoring teams and supporting legacy and modern environments.

Build, administer, and optimize enterprise Databricks data platforms in Azure. Responsibilities include platform operations, Terraform-based infrastructure automation, data ingestion enablement, governance through Unity Catalog, access controls, monitoring, troubleshooting, incident response, and reliability improvements. The role partners with data engineers, architects, analysts, infrastructure, and security teams to support scalable production analytics and data workloads.

Leads architecture and development for Akamai’s global connectivity platform. Designs software-defined network automation, eliminates operational toil, builds telemetry and observability systems, establishes CI/CD and SDLC practices, and guides capacity planning and cost optimization across routing, network fabric, and edge security systems. The role also mentors engineering teams and drives reliability engineering standards across the organization.