Top Remote Python Jobs in Houston, TX

Develops and operates scalable Azure cloud platforms integrating specialized partner technologies. Responsibilities include implementing features, participating in code reviews, applying testing and debugging practices, analyzing telemetry and incidents, using AI-assisted development tools, and contributing to deployment automation. The role collaborates with engineers, product managers, and partners to deliver reliable services for enterprise and AI infrastructure workloads.

Own production reliability and infrastructure operations for the GrayKey cloud platform. Responsibilities include AWS monitoring, incident response, vulnerability remediation, networking, IAM and Okta administration, EKS and Argo CD operations, backups, recovery testing, Terraform changes, cost optimization, automation, documentation, and compliance support. The role requires independent work during Pacific and Mountain time-zone hours and involves less than 5% travel.

Build and maintain full-stack software using TypeScript, Go, and Python, including backend, frontend, and architectural development. Collaborate with developers, designers, product managers, and Department of Defense stakeholders to develop AI-powered solutions, take products from concept to launch, conduct code reviews, and support customers through travel when needed.

Develop, test, and ship features for patient-facing applications, booking systems, clinical operations tools, and internal platforms. Collaborate with senior engineers on implementation, code reviews, debugging, troubleshooting, and automation for scheduling and patient engagement workflows. Build foundational experience with mobile applications, healthcare data systems, APIs, databases, version control, and production software while contributing to a collaborative engineering team.

Design, build, and maintain scalable applications, APIs, mobile platforms, booking systems, clinical integrations, and healthcare data systems. Own features end to end, make architectural decisions, improve security and reliability, and contribute to cloud deployment, CI/CD, monitoring, and DevOps. Collaborate with clinical, operations, and patient experience teams to deliver secure digital tools that improve patient care and clinic efficiency.

Build and scale full-stack web applications, backend services, APIs, and distributed systems. Develop React and TypeScript frontends, backend services with Python, Node.js, or Go, and cloud-native applications using AWS, Docker, and Kubernetes. Work with databases, Kafka, AI/ML integrations, automated testing, security, and performance optimization. Collaborate with product, design, and engineering teams while troubleshooting production issues and delivering reliable software.

Leads the strategy, validation, and safety assurance of Level 3–4 autonomous driving behaviors powered by machine learning. Owns behavior-related safety cases, standards alignment, ODD and evaluation frameworks, safety metrics, launch-readiness assurance, and evidence assessment across simulation, closed-course, and public-road testing. Leads cross-functional technical collaboration and builds a high-performing AV behavior safety engineering team through hiring, coaching, and development.

Develops and sustains canvas and model-driven Power Apps using Dataverse, SQL Server, SharePoint, external APIs, and premium connectors. Designs relational data models, Power Automate workflows, reusable components, and deployment solutions across environments. Collaborates with clients to define requirements, milestones, and enhancements while supporting troubleshooting, incident remediation, documentation, governance, security, and compliance. The position is fully remote within the United States and supports government contracts.

Build and operate the infrastructure supporting Legion, including CI/CD pipelines, infrastructure as code, Kubernetes environments, observability, and deployments across cloud, on-premises, and customer environments. Improve developer tooling, support secure and compliant platform operations, and assist with deployments to customer and test sites. The role requires strong Linux, networking, scripting, containerization, and production infrastructure experience, with potential support for air-gapped and mission-critical systems.

Develop and optimize Firefox performance across Windows, Android, Linux, and macOS. Write code, tests, prototypes, and tooling; profile and diagnose bottlenecks; improve benchmarks; and lead performance initiatives. Collaborate across engineering teams, educate developers, drive projects to completion, own browser performance areas, and contribute to the team’s technical roadmap.

Own developer-experience workflows from discovery through adoption, acting as product manager, designer, and engineer. Build internal tools including TypeScript and React interfaces, backend services, APIs, CLIs, CI/CD integrations, and AI-enabled workflows. Conduct user research, define product scope, design experiences, ship software, measure adoption, and drive rollout. Candidates need 5+ years of software engineering experience and experience building developer-facing products.

Hands-on fellowship for university students and recent graduates interested in AI, backend engineering, cloud infrastructure, and software delivery. Fellows may research technology trends, build internal tools and automation workflows, explore LLM-powered agents, prototype backend or cloud solutions, and prepare technical documentation and client-readiness materials. The role emphasizes ownership, reliability, clear technical communication, and practical project experience.

Build and ship customer-facing transaction features end to end, including APIs, data models, pipelines, integrations, and user interfaces. Collaborate with product and design teams, contribute high-quality code, drive technical discussions, identify risks, and deliver production systems using a modern Python stack.

Own the architecture, implementation, and operational excellence of major Azure Boost DPU software components. Develop low-level systems software spanning operating systems, virtualization, networking, storage, device management, and hardware interfaces. Lead complex cross-functional initiatives, optimize hyperscale performance and reliability, resolve system-level issues, establish engineering practices, influence platform architecture, and mentor engineers across Azure infrastructure teams.

Lead the migration and maintenance of complex data flows into AWS cloud environments. Develop infrastructure as code and cloud service logic using Python, Ansible, CloudFormation or CDK, while supporting CI/CD pipelines, file transfer and messaging services, monitoring, troubleshooting, performance tuning, and documentation. Coordinate integration requirements with stakeholders and maintain secure, compliant federal cloud solutions.

Build and scale backend systems, APIs, infrastructure, and applications for multimodal sensing and AI intelligence platforms. Responsibilities include processing sensor, audio, video, and environmental data; supporting data pipelines and model inference; ensuring reliability, scalability, and data integrity; and contributing to engineering standards and long-term technical strategy.

Leads enterprise solution architecture across applications, infrastructure, data, integrations, and processes. Defines technology blueprints, architecture roadmaps, modernization strategies, governance standards, and transformation plans. Partners with executives, business leaders, product owners, and engineering teams to align technology investments with business objectives. Evaluates emerging technologies and vendors, guides complex programs, manages technical debt, develops business cases, and mentors architects while promoting architecture excellence.

Build and deliver AI-powered healthcare products using React, Node.js, Python, and modern full-stack technologies. Partner with customers, designers, researchers, and product teams to understand workflow needs, design intuitive AI experiences, and own features from ideation through deployment, optimization, and scaling. The role requires strong product instincts, end-to-end software engineering ownership, and experience building production-grade applications.

Build and operate scalable data pipelines, backend services, APIs, and infrastructure powering AI-driven healthcare applications. Design distributed data systems, ETL workflows, streaming platforms, and cloud-native architectures while partnering with AI, machine learning, and product teams. Own production reliability, observability, security, automation, and on-call support for business-critical systems.

Build and maintain large-scale healthcare data platform software using HL7/FHIR, Apache Spark, Python, Scala, Databricks, and cloud technologies. Shape technical roadmaps, architecture, and implementation approaches; collaborate with product and business stakeholders; maintain CI/CD and staging environments; and mentor junior engineers. The role requires deep healthcare data expertise, technical leadership, and experience with modern software engineering and integration practices.

Leads a team responsible for simulation-based verification and validation of autonomous trucks. Defines V&V strategy, scenario coverage, test campaigns, toolchain requirements, and safety-case evidence aligned with automotive standards. Partners with product, systems, safety, engineering, tools teams, and vendors to establish release criteria, identify testing gaps, analyze results, and report risks and progress to leadership. The role also involves team development, simulation scenario management, and advancing autonomous vehicle validation practices.

Build and maintain full-stack software supporting patient-centered healthcare products. Contribute to architecture, technical standards, code reviews, design discussions, and reliable implementation. Collaborate with product managers, designers, and stakeholders, while advocating for privacy, security, and access to care. Mentor engineers, document knowledge, identify technical improvements, and help shape project direction. The role requires backend, database, cloud, and AI development-tool experience in a fully remote environment.

Leads a team of 4–6 senior network engineers while providing hands-on support for complex customer environments. Oversees daily operations, escalations, incident and major incident management, root cause analysis, preventive measures, performance reviews, on-call scheduling, and workload distribution. Troubleshoots and optimizes Cisco, Nexus, Meraki, Palo Alto, Check Point, F5, and SAN technologies, while supporting monitoring, automation, patching, firmware updates, and hardware lifecycle management.

Owns Site Reliability Engineering for a customer-facing SaaS platform across Azure and Azure Government. Responsibilities include monitoring and observability, incident response, root cause analysis, reliability improvements, automation, infrastructure as code, CI/CD, performance optimization, disaster recovery, and operational security. The engineer will define and track SLIs, SLOs, and error budgets, lead post-incident reviews, reduce operational toil, and collaborate with development teams on scalable, reliable platform operations.

Own the architecture, performance, reliability, and technical direction of high-traffic backend services and public APIs supporting search, browse, autocomplete, and recommendations. Lead distributed-systems design, mentor engineers, drive cross-team projects, participate in on-call and incident response, and balance scalability, latency, cost, and API compatibility.