Top Remote Software Engineer Jobs in Charleston, SC

Build and scale Airbnb’s AirChatUI AI prototyping harness and native macOS/iOS applications. Lead architecture and implementation across web prototyping, iOS deployment, AI agent integrations, AirChat tooling, and Kyber platform integration. Develop declarative UI features, collaborate with infrastructure, product, security, and design teams, and establish scalable iOS patterns. Enable designers and product managers to create production-oriented prototypes while maintaining quality, accessibility, performance, availability, and release standards.

Leads technical strategy, architecture, and implementation for scalable clinical research software, data pipelines, and AI systems. Owns product-line architecture, resolves complex distributed-systems challenges, drives reliability, security, observability, and operational excellence, and mentors senior engineers. Builds information extraction and agentic AI applications, data modeling and processing pipelines, evaluation frameworks, and cost-efficient inference orchestration. Partners across Product, QA, Data Science, Architecture, Infrastructure, Cloud, and Support to deliver reliable, maintainable systems.

Develop and maintain semiconductor equipment automation and MES integrations using SECS/GEM, SEMI standards, Ignition, Python, REST APIs, and databases. Design equipment-to-host interfaces, station controllers, finite-state workflows, data collection, tags, and web or desktop applications. Validate MES processes, support SPC software, debug and host applications, and work with hardware and semiconductor manufacturing systems. The role also requires strong analytical, communication, leadership, project management, and application ownership skills.

Design and build applications using Python, manage component design, optimize performance, and collaborate with clients on innovative products.

Lead a small software engineering team supporting intelligence workflows. Build and maintain full-stack web applications, automate workflows, develop agentic AI tools, integrate data across agency elements, and support highside services. Engage directly with customers, leadership, analysts, and developers to understand mission needs, gather feedback, implement solutions, and deliver analytic and workflow support. Responsibilities also include relational database work, pipeline data processing, and cross-domain solution development.

Evaluates AI-generated software code for correctness, quality, architecture, and debugging performance. Creates challenging coding problems, reference solutions, and test cases, then reviews model reasoning and provides detailed technical feedback to improve AI performance on real-world software engineering tasks.

Lead architecture, development, scaling, and reliability for SingleStore Helios, a multi-cloud SaaS platform. Design Kubernetes operators, controllers, networking, routing, and distributed control planes across AWS, Azure, and GCP. Build resilient Go and Python systems, support AI and vector workloads, resolve complex Tier-3 production incidents, and maintain compliance controls. Mentor engineers, author architecture documents, and influence cross-functional technical strategy.

Build and operate reliable, maintainable software for appointment-based businesses. Own product and technical initiatives from design through production, collaborate with Product and Design, contribute to architecture, and develop frontend, backend, or full-stack systems. Ensure quality through testing, code review, observability, and production support while mentoring engineers and improving development practices with AI-assisted tools.

Build and operate high-volume AWS data pipelines and bidirectional CRM integrations for educational fundraising systems. Design idempotent consumers, incremental synchronization, rate limiting, replay, migrations, monitoring, and partner-facing APIs. Collaborate with product, partner, data science, and CRM teams while improving AI-assisted engineering practices. Own major system components or end-to-end architecture, depending on level, and mentor teammates at the higher level.

Build AI platform infrastructure and developer tooling, including API gateways, model routing, integrations, observability, retrieval, caching, and model-serving systems. Develop APIs, microservices, SDKs, and internal tools that connect proprietary real estate data and AI models to production applications. Collaborate with ML engineers, contribute to architecture decisions, and own features through deployment and monitoring.

Lead a portfolio company’s engineering function by writing production code, modernizing the software development lifecycle, coaching engineers, setting the product roadmap, and implementing AI-powered development and product capabilities. The role requires rapidly learning unfamiliar technology stacks, improving legacy codebases without rewrites, operating independently, and partnering closely with general managers, operators, and customers.

Lead development of full-stack, mission-critical products using Angular, React, Node.js, and AWS serverless technologies. Own projects from product definition through deployment, integrate GraphQL APIs and machine learning systems, improve developer experience and CI/CD, collaborate with clinicians and researchers, participate in customer discovery, and mentor engineers while shaping technical architecture and engineering culture.

Lead architecture and hands-on development of Azure Kubernetes Service capabilities for AI workloads. Design secure, reliable, scalable distributed systems; coordinate engineering teams; define testing and deployment strategies; improve observability and operational readiness; investigate production issues; and mentor engineers while advancing engineering practices.

Lead development of scalable Java backend applications and high-availability cloud services. Design architectures, REST APIs, databases, caching systems, and distributed session infrastructure. Mentor engineers, drive technical initiatives, address performance and scalability challenges, and uphold quality and automation practices for endpoint management products.

Lead backend engineering strategy for Affirm’s international Identity team. Design and launch highly available distributed systems supporting KYC, user lifecycle management, and identity decisioning. Drive technical planning, cross-functional collaboration, operational excellence, monitoring, testing, and on-call readiness. Establish engineering quality standards, influence architecture, mentor team members, and deliver scalable systems using Python or Kotlin, AWS, MySQL, Spark, and Kubernetes.

Build and scale developer platform capabilities, AI-powered coding and review tools, CI/CD systems, Kubernetes infrastructure, and self-service developer workflows. Improve reliability, security, observability, and delivery speed through automation, reusable templates, guardrails, documentation, and incident-response practices. Collaborate closely with platform teammates, contribute to roadmap decisions, and communicate clearly about progress, blockers, and technical tradeoffs.

Lead performance engineering for massive-scale HPC and AI workloads across InfiniBand-connected GPU clusters. Diagnose communication bottlenecks, analyze fabric behavior, tune RDMA and QoS, develop telemetry tooling, optimize topology-aware communication, benchmark distributed workloads, and collaborate with operations and hardware vendors on next-generation interconnects.

Lead the Kyber prototyping and rapid deployment platform, setting technical direction, rebuilding it on next-generation cloud infrastructure, and scaling it for thousands of internal users. Responsibilities include hands-on coding, architecture, product integration, cross-functional collaboration, improving tools for non-technical builders, and mentoring engineers.

Build and operate Node.js and TypeScript backend services using durable workflows and AI-assisted development. Define service patterns, orchestrate migrations, maintain MCP and AI workflow tooling, and improve observability through metrics, alerts, dashboards, and tracing. Handle production incidents, contribute targeted frontend changes in React and Angular, and collaborate on architecture and code reviews in a fully remote environment.

Design, develop, and maintain provider-facing web portal microservices and highly available business applications. Collaborate with product managers and designers from ideation through deployment and maintenance, make technical decisions, conduct code reviews, mentor engineers, support QA, and contribute to compliance initiatives. The role involves modern and legacy technologies, AWS services, microservice and event-driven architectures, APIs, databases, front-end development, infrastructure as code, and secure handling of PHI.

Design and develop scalable, cloud-native APIs and a greenfield system replacing a legacy platform. Build production software using TypeScript, JavaScript, Node.js, React, GraphQL, REST, SQL, and automated testing. Contribute to architecture, performance tuning, reliability, Azure DevOps pipelines, and agile delivery while applying AI development tools and maintaining strong engineering standards.

Own Telnyx’s global phone-number ordering pipeline, carrier integrations, regulatory automation, AI-powered order review, and Postgres data layer. Build reliable async Python services with retries, rollbacks, queues, SLA monitoring, document verification, auditability, and human escalation. Improve automation across dozens of vendors and 45+ countries while maintaining dashboards, analytics, and operational alerts across a large microservice estate.

Develop and modernize SQL Server-backed data-access systems for medical imaging workflows. Responsibilities include database schema refactoring, query optimization, indexing, migration tooling, secure and reliable data access, CI/CD automation, testing, technical standards, architecture planning, code reviews, and developer mentorship. The role uses Kotlin, jOOQ, SQL Server, Liquibase, Gradle, and containerized testing to improve performance and maintainability without disrupting clinical users.

Owns the design, development, security, performance, and scalability of Cerby’s cross-browser Manifest V3 extension. Builds React and TypeScript experiences across extension surfaces, manages service-worker synchronization and authentication workflows, and ensures secure credential handling. Responsibilities include dependency and supply-chain security, testing, observability, code reviews, mentoring, cross-functional collaboration, and production delivery in an agile remote environment. The role also promotes responsible AI-assisted development practices.

Own the architecture and long-term direction of Alpaca’s Redpanda-based event streaming platform. Lead migration to event-driven systems, design scalable real-time client streaming, establish schema and library standards, shape authentication for streaming, partner on resilience and testing, mentor engineers, influence cross-team technical decisions, and participate in platform on-call. The role primarily uses Go and involves Kubernetes, Helm, PostgreSQL, observability, and distributed systems.