Top Remote Software Engineer Jobs in Charleston, SC

Designs and builds scalable applications using React and Python, contributing to component development, data storage, deployment practices, performance optimization, testing, and client requirements analysis. The role collaborates with technical leaders, clients, and distributed teams in agile environments, using Git, code reviews, cloud platforms, databases, and AI-native development practices. U.S.-based travel to client sites is required.

Build and operate secure, scalable backend services for OnePay’s co-branded credit card product. Design APIs and event-driven systems, integrate partner platforms, ensure regulatory and security compliance, and own reliability for real-time credit transactions. Collaborate with risk, compliance, and platform teams, make architecture decisions, mentor engineers, and improve code quality, testing, and operational practices.

Leads the design, development, architecture, and maintenance of scalable software systems. Provides technical leadership, conducts code reviews, ensures development best practices, and mentors junior engineers. Collaborates with technical and non-technical stakeholders to deliver reliable solutions supporting clinical decision-making and patient outcomes.

Principal Software Engineer leading architecture, development, and technical strategy for complex software platforms. The role requires designing scalable and secure systems, guiding engineering standards, mentoring engineers, resolving complex technical issues, and partnering with product, laboratory, and bioinformatics teams. Responsibilities include software architecture, React and .NET development, database optimization, REST APIs, distributed systems, DevOps, regulatory compliance, and long-term technology roadmaps supporting clinical and genomic workflows.

Build performant, accessible front-end interfaces for AI agents, dashboards, conversational user interfaces, and visualization tools. Collaborate with designers, AI engineers, and backend developers to create scalable components, optimize cross-browser experiences, and iterate on UX using testing, feedback, and usage data.

Design and optimize networking infrastructure for Azure AI supercomputing clusters. Develop RDMA communication libraries, transport protocols, distributed systems, observability tools, and performance optimizations. Analyze latency, throughput, congestion, scalability, and fault tolerance across large GPU and accelerator environments. Lead technical architecture, write design specifications, resolve complex production networking challenges, and collaborate with hardware, silicon, AI framework, and infrastructure teams.

Build and scale global payments and treasury systems using resilient, event-driven microservices. Design client-facing APIs, distributed systems, financial ledgers, and payment integrations while ensuring scalability, reliability, and system integrity. Collaborate independently and cross-functionally to define and implement solutions, troubleshoot issues, and maintain clean, tested code. Work with cloud infrastructure, Kubernetes, messaging systems, relational databases, payment rails, reconciliation, and double-entry accounting.

Design and scale automated test frameworks for Akamai’s custom Linux kernel, hardware compatibility, performance, reliability, security, and OS imaging. Develop hardware validation suites, support kernel and virtualization upgrades, troubleshoot low-level system issues, and improve continuous integration and testing infrastructure across AI and compute platforms.

Develop and maintain Akamai’s custom Linux kernel and distribution for a globally distributed cloud platform. Responsibilities include adding performance, reliability, and security features; porting modifications to newer kernels; debugging production and test issues; improving build and continuous-testing automation; collaborating with platform, application, test, and hardware teams; and contributing work upstream to the open-source Linux community.

Build and scale backend identity platform services for global user onboarding, identity verification, risk management, and trading accounts. Design reliable microservices and architectures, contribute to technical decisions, maintain code quality and test coverage, troubleshoot incidents, collaborate across teams, and potentially participate in on-call support.

Build and maintain MongoDB’s distributed database infrastructure for cluster scalability. Design data partitioning, data movement, dynamic scaling, workload execution, and resilient distributed protocols. Solve complex performance and low-latency systems problems, contribute production-quality C++ code, participate in design and code reviews, lead new feature development, and mentor engineers.

Build and maintain cloud-native applications and services for Akamai’s IaaS platform. Develop platform features from requirements through design, testing, and deployment; integrate Kubernetes and cloud-native technologies; collaborate with product owners, architects, developers, and test engineers in an Agile continuous-delivery environment. The role focuses on creating scalable, reliable, secure platforms that simplify product development and user experience.

Leads end-to-end software development for AI-infused enterprise applications, including architecture, database design, coding, testing, deployment, and service reliability. Builds Copilot and agentic solutions using Azure and modern full-stack technologies. Provides technical leadership, mentors engineers, establishes quality and security practices, supports enterprise integrations, and collaborates with product teams, program managers, UX designers, and data scientists to deliver scalable commercial software.

Lead complex, cross-team software initiatives from design through rollout; architect backend services, improve reliability and observability, guide technical strategy, mentor engineers, and elevate engineering quality. The role emphasizes AI-assisted coding, agentic development workflows, automated guardrails, testing, incident response, and solving ambiguous technical problems across consumer applications and internal tools.

Software Engineering Interns contribute to production TypeScript backend features, applied AI and computer vision pipelines, and end-to-end deployments to active mining sites. Responsibilities include using LLMs, AWS Rekognition, TensorFlow, Kubernetes, and CI/CD; translating user challenges into product features; and collaborating closely with senior engineers and leadership. The role is fully remote and emphasizes ownership, autonomy, and shipping real-world software.

Develop and maintain Akamai’s custom Linux kernel for its cloud platform. Responsibilities include adding performance, reliability, and security features; porting modifications across kernel versions; debugging production and test issues; improving build and continuous-testing automation; collaborating with platform, application, hardware, and test teams; and contributing changes upstream to the Linux community.

Develop fullstack web applications, enhance platform performance, collaborate on high-impact opportunities, and ensure stable, scalable solutions. Engage in rapid iterations and be a committed team player.

Design, develop, and operate scalable software platforms and automation for Azure network qualification infrastructure. Build tools for device provisioning, configuration, lifecycle management, testing, telemetry, and health validation. Develop AI-powered agents for troubleshooting, root-cause analysis, and engineering productivity. Create reliable distributed systems with observability, diagnostics, automated recovery, and scalability while collaborating across software and network engineering teams.

Build and operate WISEcode’s food data lakehouse using Python, SQL, DuckLake, S3 Parquet, Postgres, and Prefect. Responsibilities include source ingestion, entity resolution, pipeline consolidation, data enrichment, downstream connectors, data quality reporting, configuration discipline, and architectural documentation. The role requires designing and shipping production lakehouse or warehouse systems, managing scalable API-driven pipelines, and collaborating closely with engineers in a fully remote environment.

Develop and maintain PowerUp Sports’ software platform, build and release new features, integrate technologies, optimize PHP applications on Azure, manage SQL Server databases, participate in code reviews, mentor junior developers, and support scalable, reliable architecture.

Provides technical leadership for Azure cloud-scale distributed data platforms processing network telemetry and operational data. Defines architecture and long-term technical strategy, leads streaming and batch system design, resolves complex scalability and reliability challenges, oversees production readiness and continuous improvement, and influences cross-team technical investments. Partners across Azure Networking, conducts design reviews, establishes reusable engineering patterns, improves observability and quality, and mentors engineers and technical leaders.

Build and evolve distributed platforms, microservices, intelligent agents, and AI-enabled services. Lead hands-on software development while defining agent orchestration, Infrastructure as Code, controls-as-code, CI/CD, security, and compliance practices. Partner with systems engineers and security stakeholders, translate mission needs into scalable solutions, establish development standards, mentor engineers, and guide architecture and technical decisions in secure, regulated environments.

Design and implement scalable, secure, high-performance software systems and public-facing APIs. Lead system design, apply agentic coding workflows, collaborate with Product and Data Science, mentor engineers, and own initiatives improving efficiency, performance, and customer satisfaction. The role requires extensive experience with highly available distributed systems, API versioning and rate limiting, modern backend and frontend technologies, AWS, and Domain-Driven Design.

Develop and deploy life-saving technologies as a fullstack engineer, focusing on web applications for public safety, collaborating with various engineering disciplines and leveraging customer feedback.

Build and maintain full-stack features across core financial platforms using Python, Django, PostgreSQL, and modern JavaScript or TypeScript frameworks. Design scalable systems, implement front-end interfaces and back-end APIs, write automated tests, optimize performance, resolve bugs, participate in code reviews, collaborate cross-functionally, and guide junior engineers while using AI-assisted development tools.