Jobs at Kymera Therapeutics

Directs clinical data management activities across multiple studies, overseeing CRO deliverables, data collection tools, user acceptance testing, data quality control, cleaning, query resolution, medical coding, timelines, and budgets. Manages vendors and mentors internal team members while ensuring data integrity and security. Contributes to SOPs, process improvements, technology selection, and best practices. Requires extensive biotechnology or pharmaceutical clinical data management experience and expertise in CDISC and medical terminology standards.

Leads statistical strategy for clinical studies and programs, contributing to development plans, regulatory submissions, protocols, statistical analysis plans, clinical study reports, publications, and presentations. Oversees statistical programmers and CROs, ensures regulatory compliance and output quality, supports CRF design, and may manage direct reports. Collaborates with cross-functional teams and communicates statistical findings to non-statisticians.

The Director, Trial Master File will lead TMF platform implementation, oversee compliance, standardize processes, and ensure inspection readiness across clinical operations.

Lead Kymera's business development strategy by sourcing, evaluating, negotiating, and closing collaborations and licensing deals. Manage transactions end-to-end, coordinate cross-functional diligence, prepare partnering materials and financial analyses (NPV, forecasts, comparables), negotiate agreements, and represent the company at industry events to build strategic partnerships.

Leads cross-functional biotech R&D development programs from strategy through execution, coordinating matrix teams, integrated development plans, timelines, budgets, governance, reporting, risk mitigation, and executive stakeholder communication. Partners with program leads to drive asset strategies, resolve complex issues, improve team effectiveness, and deliver small-molecule drug development objectives. Requires substantial biotech or pharmaceutical experience, program management expertise, scientific knowledge, strategic leadership, and proficiency with project planning and tracking tools.

Lead Kymera's enterprise AI strategy and roadmap; prototype, build, and deploy AI/LLM solutions; select and govern AI platforms; establish AI governance with InfoSec; manage vendors and external engagements; drive adoption through training; and advise functional leaders to operationalize AI across research, development, regulatory, and G&A.

Lead early commercial strategy for assigned programs, including indication prioritization, market landscapes, forecasting, primary/secondary research, and competitive intelligence. Partner with cross-functional teams to shape target product profiles, evidence-generation priorities, and portfolio decisions. Use AI-enabled tools to accelerate intelligence workflows, attend scientific meetings, and deliver concise executive-ready analyses to inform development and business development opportunities.

Lead HEOR, RWE, and value strategy across Kymera's immunology portfolio. Drive economic modeling, payer engagement, AMCP dossiers, RWE plans, HTA readiness, cross-functional launch preparation, and build a high-performing outcomes and access team.

The role involves leading targeted proteomics research, developing and optimizing assays, and collaborating with project teams to inform drug discovery decisions.

Lead analytics for clinical trial feasibility and enrollment planning by integrating internal and external data, building forecasts and dashboards, monitoring study performance, assessing competitive trial landscape, automating reporting, and delivering executive-level insights to optimize study design and execution across the clinical portfolio.

Lead and grow PBPK/PBBM capabilities to predict human PK and oral bioavailability, support formulation selection and IVIVC, model DDI/food effects and special populations, embed in project teams, liaise with partners/CROs, and prepare regulatory documentation to support IND/NDA submissions and health authority interactions.

Lead strategic sourcing for R&D vendors (CROs, CMOs), manage supplier relationships, negotiate MSAs/SOWs, run RFPs and vendor selection, identify cost savings, track contract status and vendor performance, and improve sourcing processes across the organization.

Manage and maintain Kymera's electronic Quality Management System (Veeva Vault) including document control, training program administration, compliance monitoring, metrics reporting, and inspection-ready records. Support SOP lifecycle, vendor qualification, and continuous improvement to sustain QMS operations during late-stage development and commercialization.

Senior IT leader embedded in Development to define and execute technology strategy for clinical programs. Own Veeva Vault implementations (QMS, eTMF, CTMS), validated systems governance, regulatory submission readiness, vendor relationships, data integrations, and AI-enabled opportunities. Drive requirements gathering, process design, change management, and ensure GxP/21 CFR Part 11 compliance while supporting Phase 3, NDA, and commercialization scale.