Top Senior Machine Learning Jobs in Des Moines, IA

The Senior Technical Architect will lead AI SDLC transformations, create architectural solutions, mentor teams, and drive innovation in regulated industries.

Own the full lifecycle of clinical text extraction models, from problem framing and annotation strategy through production deployment, evaluation, monitoring, and retraining. Build clinical NLP pipelines, establish defensible quality and error-analysis systems, and apply LLMs using rigorous evaluation, observability, and cost controls. Partner with clinical data and backend engineering teams while addressing PHI protection, de-identification, auditability, and access controls. As the first ML hire, set technical direction and potentially build and lead the future ML team.

Lead end-to-end product strategy and delivery for a core marketplace area, collaborating with engineering, UX, and design. Conduct qualitative and quantitative research, run agile sprints, measure results with analytics, and pioneer AI/ML product features and workflows to improve user experience and platform impact.

Lead strategic vision and execution of next-generation bioinformatics technologies. Identify and evaluate emerging computational methods, translate research into production-grade pipelines and prototypes, support product roadmaps and technology transfer, and partner cross-functionally to commercialize genomic and AI-driven healthcare solutions.

Develop and scale machine learning training systems for robotics data, optimize training pipelines, and collaborate with ML researchers to enhance autonomy models.

Lead design, development, and production deployment of ML and algorithmic solutions. Own end-to-end ML systems, support distributed production reliability, communicate tradeoffs, and apply generative AI, LLM fine-tuning, RAG, and agentic techniques to product problems.

Responsible for fine-tuning state-of-the-art LLMs, optimizing models for deployment, and driving AI architectural decisions. Collaborate with cross-functional teams to develop impactful AI products.

Build and maintain scalable ML and generative AI platforms and backend infrastructure; deploy and manage production applications; create services exposing ML/AI products; implement RAG solutions and vector databases; integrate LLM orchestration and foundation model APIs; collaborate cross-functionally and mentor teammates.

Lead development of an AI-enabled Ethereum Layer 2 platform: build front-end and back-end systems, deploy and optimize AI models, create data pipelines, collaborate on model training, and contribute to product innovation and other company projects.

The Manager of RevOps/Yield analyzes patterns and data to optimize ad operations, manage vendor relationships, and oversee a remote team for revenue generation.

Embed with clients to gather requirements and design AI-driven solutions for fraud and fincrime. Architect, train, evaluate, and deploy custom AI agents and workflows, optimize model performance, establish risk metrics and evaluation pipelines, and collaborate with engineering/product teams to scale into production.

Own Oscilar's AML product suite (transaction monitoring, KYC/KYB, screening, case management, SAR filing, AI agents). Define detection rules, model calibration, data strategy, and defensible audit trails. Collaborate with engineers and compliance, use AI across discovery/design/analysis, deliver PRDs, validate models, and ship production features.

As Director of AI/ML, lead the ML organization, set technical vision, mentor a high-performing team, and contribute to model development and production deployment.

The AI & Data Science Director will lead AI strategies, foster technical leadership, support team development, and integrate generative AI into products.

The Senior Generative AI Engineer will design and deploy AI/ML solutions, focusing on Generative AI systems and their operational excellence across various sectors like R&D and Clinical Trials.

Conduct ML research for query understanding, ranking, clustering, and AI-powered search. Prototype and productionize algorithms, define data and evaluation requirements, design scalable systems, collaborate with engineers, run experiments, and publish patents/papers to integrate state-of-the-art ML into Yahoo Search products.

Lead design, training, fine-tuning, and deployment of ML and generative models (LLMs, diffusion). Build scalable MLOps pipelines, vectorization and data ingestion, integrate models into microservices for low-latency inference, implement evaluation/alignment/bias-mitigation, optimize models (quantization, distillation), and mentor engineers while influencing the AI product roadmap.

Design real-world ML and NLP tasks, build reference solutions and evaluation frameworks in Python, assess LLM outputs for correctness and reasoning, identify failure modes, create scoring rubrics, and collaborate with experts to improve model capabilities. Part-time, remote contractor (~20 hours/week).

Lead design, development, and productionization of advanced ML models and data pipelines. Drive architecture, experimentation, validation, and best practices while mentoring ML engineers and delivering scalable, business-driving AI solutions.

The Machine Learning Engineer will develop software solutions, optimize data pipelines, and deploy machine learning models using cloud platforms and best practices.

Design, build, and deploy high-throughput ML and LLM-powered personalization and agentic systems at consumer scale. Process petabyte-scale data, optimize real-time inference, implement resilient fallback paths, and balance latency, cost, and model quality while collaborating across engineering and product teams.

Lead a team to develop groundbreaking technology combining NLP, big data, and AI to enhance digital communication and interaction.

Design, build, and scale low-latency distributed platform components; define technical vision and architecture; collaborate with product and ML teams; evaluate build-vs-buy decisions; prototype research breakthroughs and deliver robust, production-grade services.

Lead full-cycle enterprise sales into Fortune 500 retailers, marketplaces, and travel companies. Manage eight-figure deals with C-suite and technical buyers, coordinate internal resources, build procurement-ready ROI/business cases, run pilots/A-B tests, and drive land-and-expand growth while shaping GTM playbooks.

Lead credit analytics for the Send Now Pay Later product: build and own valuation and vintage models, manage credit policies, monitor portfolio health and NPL trends, integrate ML scorecards, and evaluate alternative data to optimize approvals and loss performance.