Top Senior Machine Learning Jobs in Des Moines, IA

Lead execution of Product Engineering AI and automation initiatives across photonics products. Build and deploy reusable AI/automation tools, transform engineering data into AI-ready systems, and drive cross-functional adoption to improve development, qualification, manufacturing, and reliability processes.

Set the technical direction for machine learning at Payabli by maturing production risk models and launching new models across the payments lifecycle. Establish experimentation, monitoring, drift detection, benchmarking, retraining, and incident-response foundations. Translate payments challenges into modeling opportunities, connect model performance to business outcomes, influence the ML roadmap, and mentor engineers while partnering with product, engineering, and risk operations.

Lead a consortium advancing AI-driven neurodegeneration research: set strategy, build partnerships, manage multidisciplinary executive team, oversee product development and deployment, secure funding, ensure ethical AI and scientific integrity, and scale the platform to broader biomedical domains.

The AI Engineer will design and build production systems, focusing on LLM integration, system reliability, evaluation frameworks, and high-quality product features while maintaining strong engineering practices.

Lead end-to-end delivery of LOIS by owning the master program plan, coordinating cross-functional teams (engineering, product, design, ML, data, SRE, operations), resolving blockers and dependencies, establishing lightweight delivery infrastructure and tooling, partnering on release planning, and maintaining transparent status, risks, and accountability to deliver complex features to customers.

Design, optimize, and scale ClickUp's search infrastructure using OpenSearch/ElasticSearch. Improve relevance, speed, and real-time indexing; build vector/semantic search capabilities; create measurement frameworks; integrate search with AI and product features; troubleshoot at scale; and mentor junior engineers to maintain high search quality under heavy load.

Design, scale, and optimize ClickUp's search infrastructure using OpenSearch/Elasticsearch. Improve relevance, speed, and real-time indexing, build vector search capabilities, create evaluation frameworks, and collaborate with AI/backend/product teams to integrate and troubleshoot search at scale.

The Senior Backend Data Engineer will extend data ingestion and processing pipelines, build APIs and backend services, and provide technical leadership.

Lead Tekmetric's API product strategy and roadmap for the SaaS platform. Own API lifecycle (contracts, versioning, documentation), drive developer experience and adoption, identify integration opportunities, lead generative AI initiatives, perform user research and analytics-driven prioritization, collaborate across design/engineering/sales, train internal teams, and measure business impact.

Lead development of Vanta's business analytics function: build scalable product data assets, define measurement frameworks, use AI-assisted analytics, partner with cross-functional teams, and deliver executive-level recommendations to drive product and business decisions.

Lead and grow a global engineering team building endpoint visibility, prevention, and on-device ML across Windows, macOS, and Linux. Own roadmap and delivery, direct model development and telemetry, drive cross-platform protection parity, coordinate with product and partner teams, and represent the team externally through research and conferences.

Lead the vision and execution of data product roadmap; translate business needs into epics and acceptance criteria; partner with data engineering and analytics; run agile ceremonies and manage backlog; champion data-as-a-product; scope and pilot AI/ML capabilities; present roadmaps and business cases to leadership.

Full-cycle territory sales role selling Greenway Health's EHR, RCM, and AI-driven healthcare solutions. Responsibilities include prospecting, lead generation, demos, RFP management, proposal configuration, negotiation, closing, maintaining Salesforce, meeting quota, and providing market feedback. Role requires heavy travel (50–75%) and collaboration with internal solutions consultants to deliver value-based technology and revenue cycle capabilities to ambulatory healthcare clients.

Conduct research and develop identity and probabilistic-matching models for Netflix's ad-supported tier. Apply ML and statistical methods, ensure privacy-preserving solutions (differential privacy, anonymization), prototype and deploy production models, deliver datasets and tools, and partner with product, engineering, and business stakeholders to measure and drive impact.

Design, build, and operate core AI capabilities and reusable model integrations for an enterprise platform. Integrate foundation models into production, optimize performance and reliability, prototype new techniques, and support scalable backend services and distributed AI systems in collaboration with cross-functional teams.

Own end-to-end product development for AI/ML revenue cycle solutions: define vision and roadmap, write specs and user stories, prioritize backlog, work closely with data scientists and engineers, drive agile delivery, ensure quality, and measure product performance with stakeholders.

Lead and mature Omada's enterprise privacy program, manage HIPAA compliance and incident response, embed privacy-by-design across products, conduct privacy risk assessments and vendor due diligence, advise on consumer privacy and AI governance, support interoperability/HIE participation, and deliver privacy training and guidance across the business.

The Staff Machine Learning Engineer will lead ML systems development for personalization and ranking, design architectures, and mentor team members, ensuring reliable operations at scale.

Provide legal counsel on privacy, AI, identity, and advertising technology; embed privacy by design with product and engineering teams; draft and negotiate privacy provisions and DPAs; advise on cross-border transfers and SCCs; run privacy and AI risk assessments; support incident response; create scalable legal playbooks and AI-enabled workflows; represent Yahoo in industry standards bodies.

The Machine Learning Engineer will work on unstructured data classification and clustering, utilizing their expertise in AI systems and various programming languages.

The Senior Machine Learning Engineer will utilize deep experience and insights to enhance communication and digital interactions through advanced machine learning tools and algorithms, focusing on unstructured data.

The Staff Data Scientist will lead the development and deployment of ML and GenAI systems to detect billing errors and fraud in healthcare payments, collaborating with cross-functional teams.

Lead and develop a team of five East Coast Enterprise Sales Leaders to drive new logo acquisition and account expansion. Build sales plans, manage pipeline from lead generation through close, recruit and coach leaders, and contribute to GTM strategy while reporting to the VP of Enterprise Sales. Remote-first role with occasional off-hours work.

Drive technical wins for enterprise financial institutions by scoping solutions, leading discovery (MEDDPICC), tailoring demos, building business cases, owning RFI/RFPs and POCs, and coordinating product/engineering to validate feasibility for fraud and financial crime prevention.

Lead product vision and roadmap for Tekion's Automotive CRM, translate dealer and partner needs into product requirements, define AI/LLM-enabled CRM capabilities, collaborate cross-functionally to deliver SaaS CRM features, create product artifacts, measure success metrics, and prioritize initiatives to drive adoption and strategic account success.