NGS Scientist I

Posted 18 Hours Ago
Be an Early Applicant
Chicago, IL, USA
Hybrid
75K-95K Annually
Senior level
Artificial Intelligence • Big Data • Healthtech • Machine Learning • Analytics • Biotech • Generative AI
Tempus is a technology company leading the adoption of AI to advance precision medicine and patient care.
The Role
Develop, optimize, qualify, and validate molecular and NGS-based assays for deployment in a regulated clinical laboratory. Conduct rigorous R&D experiments, analyze and troubleshoot results, improve workflows, support automation, document methods, train junior staff, and collaborate across technical teams. The role requires experience in molecular biology or assay development, with preferred expertise in PCR, nucleic acid workflows, NGS, laboratory automation, and clinical laboratory operations. Travel is up to 10%.
Summary Generated by Built In

Passionate about precision medicine and advancing the healthcare industry?

Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.

At Tempus, we are leveraging the power of AI to transform clinical care. Our proprietary platform connects a vast ecosystem of real-world data to deliver intelligent, actionable insights that help physicians make more informed decisions and enable personalized treatment for patients.

We are seeking a Scientist to support the development, optimization and validation of molecular assays and laboratory processes for deployment in our high-throughput clinical laboratory.

What You’ll Do
  • Perform hands-on assay development for advanced molecular and NGS-based workflows in a CAP/CLIA/NYSDOH regulated clinical laboratory

  • Design, execute, and analyze R&D experiments with strong attention to detail and scientific rigor

  • Design and execute qualification and validation studies for reagents, instruments, equipment, and methods to support clinical deployment.

  • Interpret data, troubleshoot issues, and drive process improvements.

  • Support automation and technology initiatives to improve laboratory workflows.

  • Maintain clear and comprehensive documentation of methods, materials, and results

  • Train and mentor junior scientific staff and support implementation of new laboratory workflows as needed

  • Collaborate across cross-functional teams and provide scientific support in a matrixed environment.

  • Communicate clearly and effectively with technical and non-technical stakeholders.

  • Manage multiple priorities and adapt quickly in a fast-paced environment.

  • Travel up to 10% as needed

Qualifications
  • Bachelor’s degree with 5+ years, or Master’s degree with 2+ years of relevant experience in molecular biology, assay development, or a related field.

  • Strong analytical, troubleshooting, and experimental design skills.

  • Ability to interpret results using scientific literature and SME input to refine experimental design

  • Highly organized, detail-oriented, and committed to quality and accuracy.

  • Proven ability to learn quickly and adapt to new processes, technologies, and workflows.

  • Strong collaboration skills with the ability to lead across teams.

  • Excellent oral and written communication skills.

  • Experience working in dynamic environments with competing priorities and deadlines

  • Ability to interpret results using scientific literature and SME input to refine experimental design

Preferred Technical Experience
  • Hands-on experience with one or more of the following:

  • DNA/RNA extraction and purification methods.

  • PCR-based techniques, including PCR, qPCR, RT-PCR, and ddPCR.

  • Nucleic acid manipulation, quantitation, and analysis.

  • Assay troubleshooting, root cause analysis, and workflow optimization.

Highly Desirable
  • NGS library preparation, hybrid capture, and sequencing workflows.

  • Experience with laboratory automation and liquid handling robotics

  • Prior experience in a clinical laboratory environment

  • Familiarity with LIMS and laboratory data systems

CHI: $75,000-$95,000

The expected salary range may vary for other locations. Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.

We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. 

Skills Required

  • Bachelor's degree with 5+ years of relevant experience, or Master's degree with 2+ years of relevant experience in molecular biology, assay development, or a related field
  • Strong analytical, troubleshooting, and experimental design skills
  • Ability to interpret results using scientific literature and subject matter expert input
  • Strong organization, attention to detail, and commitment to quality and accuracy
  • Ability to learn quickly and adapt to new processes, technologies, and workflows
  • Strong collaboration skills and ability to lead across teams
  • Excellent oral and written communication skills
  • Experience working in dynamic environments with competing priorities and deadlines
  • Hands-on experience with DNA/RNA extraction and purification methods
  • Hands-on experience with PCR, qPCR, RT-PCR, or ddPCR
  • Experience with nucleic acid manipulation, quantitation, and analysis
  • Experience with assay troubleshooting, root cause analysis, and workflow optimization
  • NGS library preparation, hybrid capture, and sequencing workflow experience
  • Experience with laboratory automation and liquid-handling robotics
  • Prior experience in a clinical laboratory environment
  • Familiarity with LIMS and laboratory data systems

What the Team is Saying

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Tempus AI Compensation & Benefits Highlights

  • Healthcare Strength Health coverage is described as comprehensive, including medical, dental, vision, life and disability insurance, plus mental‑health resources and HSA/FSA options, with core items employer‑verified in mid‑2026.
  • Leave & Time Off Breadth Paid time off and parental leave are consistently part of the package, with parental leave commonly cited around three months and related pages noted as recently employer‑verified.
  • Wellbeing & Lifestyle Benefits Everyday perks such as commuter benefits, on‑site meals and coffee programs, gym discounts, charitable matching, ERGs, pet insurance, and team events are widely highlighted, with some amenities available in select offices.

Tempus AI Insights

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The Company
HQ: Chicago, IL
3,775 Employees
Year Founded: 2015

What We Do

We bring together one of the world’s largest libraries of multimodal clinical and molecular data with a robust suite of AI tools to help physicians personalize care in real time, connect patients with therapies and clinical trials, and enable partners to accelerate discovery and development of new treatments. With ~8 million de-identified research records and 350+ petabytes of data, Tempus partners with more than half of U.S. oncologists and the majority of the top 20 global pharma companies. Our teams are pioneering work across oncology, neurology, psychiatry, cardiology, and beyond—transforming how care is delivered and therapies are developed. At Tempus, every role contributes to our mission: to help each patient benefit from the experiences of those who came before. For more information, visit tempus.com.

Why Work With Us

We’re looking for people who can change the world. People who question the status quo and refuse to shy away from tough problems. For builders who are never done building, and the learners who are never done learning. Passionate individuals with undying curiosity who want to take on one of the greatest challenges humanity has ever faced—head on.

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Tempus AI Offices

Hybrid Workspace

Employees engage in a combination of remote and on-site work.

Most of the team follows a hybrid policy, with some roles allowing for a fully remote arrangement and some roles being onsite only.

Typical time on-site: 3 days a week
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