We’re seeking a DMPK Scientist to join us in our mission to transform the discovery of therapeutics!
Our drug discovery and preclinical development team includes a cross-functional group of scientists and drug developers with experience working on all common target classes and therapeutic areas. The group is supported by more than 100 software developers and engineers, as well as a large-scale compute infrastructure to apply our proprietary physics based drug design and optimization platform. Ten of the programs we’ve worked on have progressed into preclinical development, with nine currently in clinical trials and one approved by the FDA.
Who will love this job:
- A DMPK analysis expert, who understands ADME principles and applications throughout drug development applications throughout drug discovery and development
- A scientist with a robust background in DMPK who has specialized in the use and application of any of the following:
o In vitro/in vivo drug metabolism or transporter approaches to identify potential ADME liabilities and aid in compound optimization
o PK/PD and PBPK modeling approaches to optimize compound selection, dose optimization, and study design (this includes experience with commonly-used PK/PD software, such as Phoenix/WinNonlin, SimCYP, Monolix, MATLAB SimBiology, or other equivalent software)
- A proven Principal Investigator and scientific strategist who’s self-driven and results-oriented
- A highly motivated, self-driven, and results-oriented data-analyzer
- An excellent communicator and presenter who can work both as a team player and a project driver
- A flexible, curious scientist who’s excited about networking and building internal and external relationships
What you will do:
- Develop and drive DMPK and PK/PD strategy for drug discovery projects
- Represent the DMPK group on internal and intercompany project teams to help turn molecular modeling design ideas into druggable novel chemical entities
- Collaborate with internal and intercompany project team members and external CROs to generate relevant data to enable knowledge and data integration
- Analyze and integrate in silico ADME predictive solutions, physicochemical, ADME, and DMPK data to impact multiparameter optimization
- Author and/or review appropriate reports for regulatory submission of development drug candidates and ensure the overall quality of the studies and interpretation (this entails supporting interactions with regulatory agencies)
- Collaborate with scientific development team on establishment of predictive computational ADME/DMPK models
What you should have:
- PhD in life sciences, chemical engineering, pharmacokinetics, pharmaceutical sciences, or a related discipline with at least five years of experience working with DMPK in the pharmaceutical industry or Master’s degree in life sciences, chemical engineering, pharmacokinetics, pharmaceutical sciences, or a related discipline with at least ten years of experience working with DMPK in the pharmaceutical industry
- Prior experience independently representing DMPK on project teams
Skills Required
- PhD in life sciences, chemical engineering, pharmacokinetics, pharmaceutical sciences, or a related discipline, plus at least five years of pharmaceutical-industry DMPK experience
- Alternatively, a Master's degree in a related discipline plus at least ten years of pharmaceutical-industry DMPK experience
- Experience independently representing DMPK on project teams
Schrödinger, Inc. Compensation & Benefits Highlights
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Leave & Time Off Breadth — Time off includes over a month of paid vacation plus two annual company‑wide shutdown weeks. This breadth stands out in the package and supports meaningful disconnection.
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Healthcare Strength — Coverage spans medical, dental, vision, mental‑health resources, an EAP, FSAs, and employer‑paid short‑ and long‑term disability. The scope of these offerings positions health support as a core pillar of total rewards.
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Parental & Family Support — Benefits extend to paid parental leave, subsidized backup care for children, elders, and pets, as well as fertility coverage, reproductive‑health travel reimbursement, and compassionate leave. This depth of family support is a notable advantage across life stages.
Schrödinger, Inc. Insights
What We Do
Schrödinger is a leading provider of advanced molecular simulations and enterprise software solutions and services for pharmaceutical, biotechnology, and materials science research. The predictive power of Schrödinger's software allows scientists to accelerate their research and development, reduce research costs, and make novel discoveries.
Why Work With Us
We have a mission-driven culture that thrives off team collaboration. By utilizing a non-hierarchal approach, we hope to give all employees a voice and room to grow to their fullest potential. We actively engage in diversity and inclusion efforts, pay fairly, and always strive to provide a supportive atmosphere for our teams.
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Schrödinger, Inc. Offices
Hybrid Workspace
Employees engage in a combination of remote and on-site work.
