Jobs at Rhythm Pharmaceuticals

Develop, validate, and QC analysis datasets, tables, listings, and figures for clinical studies and regulatory submissions. Create ADaM specs, TLF shells, reusable macros, and submission-ready documentation (define.xml, reviewer guides). Partner with Biostatistics, Data Management, Clinical Development, and vendors; identify risks, drive process improvements, and mentor junior programmers as needed.

The Treasury Manager oversees cash operations, banking administration, compliance, financial analysis, and partnerships to optimize liquidity and streamline treasury functions.

The Head of Global Strategic Sourcing leads the strategic sourcing function, manages supplier relationships, and ensures alignment with business objectives. Responsibilities include executing sourcing vision, optimizing costs, building supplier partnerships, and establishing governance frameworks.

Provide strategic and technical leadership for analytical development and QC across the product lifecycle. Define control strategies, lead method development/validation/transfer, oversee stability and impurity programs, ensure cGMP/data integrity compliance, manage CDMO/CRO partnerships, support regulatory CMC submissions and inspections, and build a high-performing analytical organization.

The (Senior) Brand Manager for GSA will lead and execute localized marketing strategies, oversee integrated initiatives, manage compliance, build stakeholder relationships, and analyze performance metrics.

Manage the Eastern Canada territory across Quebec and Atlantic provinces for a specialty biopharmaceutical company. Develop territory business plans, achieve sales targets, build relationships with healthcare professionals, communicate clinical information, execute educational and conference activities, report CRM data, manage budgets, and maintain compliance. The role requires frequent field travel, French and English fluency, and at least six years of specialty pharmaceutical or biotech sales experience.

Serves as statistical lead for clinical studies and program activities, supporting study design, sample size calculations, SAPs, analyses, TLFs, interim analyses, regulatory submissions, and interpretation of results. Collaborates with clinical, regulatory, safety, data management, programming, and external vendor teams. Reviews statistical outputs, ensures quality and compliance, contributes to inspection readiness, and supports process improvements in a fast-paced biotech environment.

Leads biostatistical strategy for clinical development programs, including study design, sample size calculations, protocols, SAPs, analyses, TLFs, regulatory submissions, interim analyses, and interpretation of results. Collaborates with clinical, regulatory, safety, data management, programming, and medical writing teams; oversees statistical vendors; supports publications and process improvements; and provides strategic leadership in a dynamic biotech environment.

Provide legal support for global clinical operations including drafting, reviewing, and negotiating clinical trial contracts (CROs, sites, vendors), lead CLM processes and playbooks, advise business leaders on risk-based strategies, manage outside counsel, and contribute to cross-functional life sciences legal matters.

Lead GCP/GLP/GVP quality oversight for clinical studies, manage QMS and vendor audit programs, develop SOPs and training, support regulatory inspections, review clinical and safety documents, identify and mitigate compliance risks, and partner cross-functionally to ensure GCP compliance and quality across programs.

Lead cross-functional program strategy and operations for biopharmaceutical development programs. Develop and maintain integrated plans, timelines, budgets, and risk logs; facilitate core team meetings, escalate issues to senior leadership, drive process improvements, and support decision-making across clinical development through regulatory submission.

Serve as IT business analyst for G&A functions (Legal, HR, Procurement) supporting implementation, requirements gathering, testing, change management, governance, and compliance for global systems (Ironclad, Coupa, MediSpend, ADP). Coordinate vendors, support auditors, and communicate status and risks to leadership.

Field-based territory manager responsible for promoting IMCIVREE for Acquired Hypothalamic Obesity. Provide disease and branded education to HCPs, build relationships with specialists, support prescriber enrollment and patient services, collaborate with MSLs and marketing, report in CRM, attend conferences, and achieve territory sales objectives. Frequent travel (up to 80%) required.

Manage day-to-day administration of Veeva QDocs/eQMS, support GxP document lifecycle and end-user troubleshooting, implement QMS improvements, assist complaint intake, coordinate training, participate in GxP IT system validation, perform supplier audits, and support inspection readiness to ensure GMP/GDP compliance for clinical and commercial products.

Lead development and deployment of AI-driven phenotyping pipelines using EMR and real-world data to define cohorts, extract features, and validate phenotypes. Integrate clinical, genomics, and biomarker datasets, build reproducible SQL/Python/R pipelines, apply statistical genetics and rare variant analyses, and improve data infrastructure to support Genetics-led programs.

Lead and oversee pharmacovigilance operations across clinical and post-marketing products, manage safety case processing and PV vendors, contribute to global aggregate safety reports (PBRER/PSUR/DSUR), provide PV input to clinical and regulatory documents, support audits and process improvements, and mentor junior staff to ensure regulatory compliance and high-quality safety data.

Lead end-to-end development and lifecycle management of drug-device combination products (prefilled syringes, auto-injectors). Own DHF and design controls, drive verification/validation, human factors, risk management, regulatory support, and manufacturing tech transfer. Manage cross-functional teams and external vendors/CDMOs to deliver patient-centric, compliant devices from late-stage development through commercialization.

Field-based territory manager responsible for promoting IMCIVREE for Bardet-Biedl syndrome across a Northwest territory. Build relationships with specialists, deliver disease and branded education, support prescriber enrollment and patient services, collaborate with MSL and marketing, maintain CRM records, and meet sales objectives while complying with regulatory and company standards. Heavy travel and budget management required.

The Director of Nonclinical Development leads and executes nonclinical strategies, manages CRO relationships, and contributes to regulatory submissions for clinical programs.

The Territory Manager will handle sales for IMCIVREE® focused on Bardet-Biedl syndrome, educate HCPs, and develop physician relationships while ensuring compliance and operational responsibilities.