Jobs at Nurix Therapeutics

Leads global clinical development programs from Phase 1 through approval and launch. Provides medical oversight for clinical trials, protocol design, safety and clinical data review, regulatory interactions, CRO and operational oversight, and cross-functional program leadership. Partners with executive, scientific, regulatory, commercial, and technical teams to develop strategy, manage risks, support IND/NDA/MAA activities, and communicate program results to internal and external stakeholders.

The Associate Director will manage the Computer Systems Assurance program, ensuring compliance with regulatory guidelines, leading validation activities, and supporting operational quality within a biotech environment.

Perform bioanalytical method development and LC-MS/MS quantitation for in vitro and in vivo ADME/DMPK studies, including MetID with LC-QTOF, PK sample analysis, CRO project management, data reporting, and maintaining electronic lab notebooks to support drug discovery programs.

Support the CHRO as a trusted executive partner by managing calendars, communications, approvals, travel, expenses, and confidential information. Plan and execute company events, employee experiences, and culture initiatives while coordinating stakeholders, vendors, budgets, and timelines. Contribute to HR special projects, build cross-functional relationships, and help promote an inclusive, connected workplace.

The Protein Expression Research Associate will coordinate and execute activities necessary for recombinant protein expression in insect and mammalian cell systems, document results, and maintain cultures.

The Director of Regulatory Affairs develops global regulatory strategies and leads interactions with health authorities for clinical submissions, focusing on immunology and inflammation.

Lead quality oversight of global supply chain activities for clinical programs, ensuring GMP/GDP compliance across suppliers, CMOs, warehouses, and logistics. Manage supplier qualification, audits, deviation/CAPA investigations, shipping validations, and quality agreements while partnering with cross-functional teams to maintain timely, compliant supply of clinical materials.

Lead design and execution of in vitro pharmacology and screening workflows for Degrader Antibody Conjugates (DACs). Develop and run cellular assays characterizing DAC activity, maintain cell lines, interpret data, provide go/no-go recommendations, and partner cross-functionally to advance candidates. Mentor scientists and present findings to project teams and leadership.

Manage integrated project plans and partner governance for IND-enabling and early clinical programs. Coordinate cross-functional teams, maintain timelines, track risks/issues, drive decisions, manage meeting rhythms and action-item follow-up, and support resourcing, forecasting, and PM tool/process improvements.

Develop, optimize, and validate antibody bioconjugation chemistries scalable from bench to multi-mg production. Design automation-ready protocols, execute conjugation runs, purify and characterize conjugates (FPLC, TFF, HPLC, LC-MS), write SOPs and technical reports, train automation staff, and collaborate cross-functionally with chemistry, protein biochemistry, computational teams, and CROs/CDMOs.

Lead end-to-end IT infrastructure and operations including cybersecurity operations, end-user services, and ITSM. Consolidate MSPs, build a SOC, align research and scientific computing with IT, manage AWS/HPC/container environments, establish IAM, and improve vendor and service management.

Lead development of analytical workflows for degrader antibody conjugate (DAC) characterization. Design and execute assays (DAR, aggregation, protein quantitation, SEC, HIC, peptide mapping), establish QC thresholds, perform in-depth antibody/DAC characterization (positional isomers, glycosylation, stability), integrate data for go/no-go decisions, and communicate results to cross-functional teams.

Lead development and execution of global regulatory strategy for oncology (solid tumors), manage preparation of high-quality IND/CTA/NDA/MAA submissions, interact with health authorities, track submission deliverables, and guide cross-functional teams to mitigate regulatory risk and ensure compliance.