Top Remote Senior Level Jobs in Buffalo, NY

Build and maintain modern data-centric applications, pipelines, transformations, enrichment processes, provisioning layers, and user interfaces supporting clinical and operational healthcare processes. Analyze clinical data and report trends using cloud, big data, data science, and modern software development practices. Collaborate with Product, Platform, and Architecture teams, mentor Data Engineers, document solutions, manage source control, and research emerging technologies.

Leads enterprise OpenShift Virtualization operations, including platform design, administration, monitoring, troubleshooting, security, resilience, and VM lifecycle management. Oversees VMware-to-OpenShift migration waves using MTV/Forklift, coordinates incidents and maintenance in a 24x7 environment, leads virtualization operations teams, and maintains compliance documentation, runbooks, and infrastructure-as-code configurations.

Coordinate end-to-end quoting for Aerospace & Defense ITAR projects: analyze drawings and BOMs, validate material and labor costs, format BOMs, collaborate with engineering, manufacturing, and suppliers, ensure ITAR compliance, and deliver accurate, competitive quotes on time.

Lead consulting projects for state Health and Human Services agencies, including IT planning and procurement, systems implementation, IV&V, QA/testing, business process improvement, governance, and vendor oversight. Manage project teams, work plans, budgets, deliverables, risks, and executive communications. Facilitate stakeholder meetings, advise clients, mentor staff, and support business development. The role requires state HHS experience, PMP certification, technology expertise, strong communication skills, and up to 50% nationwide travel.

Lead accounting operations for a credit union: prepare financial statements, oversee regulatory filings (NCUA Call Reports), manage general ledger and reconciliations, direct accounting staff, maintain internal controls and CECL allowance processes, drive month/quarter/year-end close, coordinate audits and regulatory exams, support CFO with financial analysis, and implement process improvements and automation.

Leads end-to-end UX research for healthcare products, including discovery planning, participant recruitment, interviews, surveys, usability testing, analysis, and synthesis. Translates qualitative and quantitative findings into product and design recommendations, partners with Product, UX Design, Engineering, and customer teams, communicates insights to leadership, and provides research project leadership.

Architects and validates field go-to-market motions for newly launched enterprise security products. Designs demos, proof-of-value structures, messaging, and scalable sales processes; conducts customer discovery and live-deal testing; analyzes competitive losses; and communicates product and positioning insights to Product Management and Product Marketing. Owns the General Availability handoff, documenting successful approaches and enabling the field to execute independently.

Recruit technical and engineering professionals for biotech, pharmaceutical, life sciences, and regulated manufacturing roles. Manage recruiting from intake and sourcing through screening, interview coordination, and offer support. Build passive candidate pipelines, assess technical qualifications, advise hiring managers on talent markets, maintain ATS records, and manage multiple requisitions in a fast-paced environment.

Define and govern enterprise application architecture across quoting, catalog, and pricing portfolios. Design APIs, integrations, cloud-native and containerized solutions while ensuring security, scalability, performance, resilience, and cost efficiency. Establish architecture governance, documentation, disaster recovery, observability, and Infrastructure as Code practices. Partner with stakeholders and engineering teams to translate business requirements into technical solutions, evaluate emerging technologies, lead proofs of concept, and mentor teams.

Build and operate an AI-driven global sourcing platform covering web crawling, data ingestion, normalization, entity resolution, product matching, provenance, and source monitoring. Integrate Zoho CRM and QuickBooks, apply LLMs with structured evaluation and human review, and identify automation opportunities across business departments. Lead pilots, train employees, measure impact, and scale the platform to hundreds of sources.