Staff Software Development Engineer (MCED, Lab, Data Technology) #4907

Posted An Hour Ago
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Menlo Park, CA, USA
Hybrid
169K-224K Annually
Senior level
Artificial Intelligence • Big Data • Healthtech • Machine Learning • Software • Biotech
GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured.
The Role
Lead design, development, testing, and deployment of large-scale software systems. Define architecture and best practices, mentor engineers, collaborate with stakeholders, ensure regulatory and security compliance, and drive platform strategy and technical excellence.
Summary Generated by Built In
Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.

We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.

GRAIL is headquartered in the bay area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.

For more information, please visit grail.com

The Staff Software Development Engineer is a senior technical role responsible for leading the design, development, and delivery of large-scale, complex software systems. This position serves as a technical expert within the engineering organization, providing direction on architecture, best practices, and long-term technical strategy. The Staff Engineer partners with cross-functional stakeholders to align technical solutions with business goals while mentoring and guiding engineering teams to elevate overall capability and performance.
 
This role is based in Menlo Park, California, and will move to Sunnyvale, California in Fall 2026 OR possibly Durham NC. It offers a flexible work arrangement, with the ability to work from GRAIL's office or from home. Our current flexible work arrangement policy requires that a minimum of 60%, or 24 hours, of your total work week be on-site. Your specific schedule, determined in collaboration with your manager, will align with team and business needs and could exceed the 60% requirement for the site. At our Menlo Park campus, Tuesdays and Thursdays are the key days where we encourage on-site presence to engage in events and on-site activities. 

Responsibilities

  • Lead the end-to-end design, development, testing, and deployment of highly complex and scalable software solutions.

  • Define and enforce software architecture principles, coding standards, and technical best practices across teams.

  • Serve as a technical authority and provide guidance on complex system design, integrations, and platform-level decisions.

  • Collaborate with product management and business stakeholders to shape technical strategy and translate requirements into solutions.

  • Mentor, coach, and provide technical leadership to engineers at all levels, fostering growth and skill development.

  • Conduct deep technical reviews of designs and implementations to ensure quality, performance, and maintainability.

  • Identify, evaluate, and implement new tools, frameworks, and technologies to improve efficiency and system capability.

  • Troubleshoot and resolve the most challenging technical issues across multiple domains and systems.

  • Contribute to roadmap planning and long-term platform evolution strategies.

  • Promote a culture of engineering excellence, innovation, and continuous improvement.
     

  • Adaptability and Growth Expectation

    As our organization continues to evolve and grow, this role may require flexibility in responsibilities and duties.  Employees should expect that their role may expand, shift, or be modified to meet changing business needs, strategic priorities, and organizational objectives.
     

    This may include:

  • Taking on additional responsibilities.

  • Participating in cross functional projects and initiatives. 

  • Adapting to new technologies, processes, or methodologies.

  • Supporting other departments or teams during periods of high demand.

  • Contributing to special projects or temporary assignments as needed.

  • These job duties are a summary of the primary duties and responsibilities of the job and position. It is not intended to be a comprehensive or all-inclusive listing of duties and responsibilities. Contents are subject to change at the company's discretion. 

Required Skills

  • Bachelor’s degree in Computer Science, Software Engineering, or related field; Master’s or PhD preferred.

  • 8–12 years of relevant software development experience with a proven record of technical leadership.

  • Advanced proficiency in multiple programming languages and frameworks (e.g., Java, Python, C#, C++, JavaScript/TypeScript).

  • Deep understanding of software architecture, distributed systems, and cloud-based environments (AWS, Azure, GCP).

  • Demonstrated experience designing and delivering complex, high-scale, and mission-critical systems.

  • Strong background in databases, system integration, security, and API development.

  • Proficiency with CI/CD pipelines, DevOps practices, and agile development methodologies.

  • Demonstrated level of knowledge regarding applicable regulatory standards commensurate with the position's complexity and scope, contributing to organizational regulatory compliance. Minimal applicable standards for this position include: 

  • Cybersecurity principles, tools, and control frameworks (e.g. ISO 27001, NIST, SOC 2, HIPAA)

  • Operations within the regulated medical device environment (e.g. IVDD, IVDR, FDA 21 CFR 800 series, FDA 21 CFR Part 11)

  • Essential Skills  

  • Exceptional problem-solving and analytical skills with ability to handle ambiguous, high-impact technical challenges.

  • Strong leadership and influence skills, able to drive alignment across teams and stakeholders.

  • Excellent communication and collaboration skills, with ability to convey technical strategies to both technical and non-technical audiences.

  • Proven mentoring and coaching ability to develop talent within the engineering organization.

  • Strategic thinking with a balance between long-term vision and short-term delivery.

  • High adaptability, embracing evolving technologies and innovative approaches.


Working Conditions

  • Standard office or hybrid work environment depending on company policy.

  • Frequent use of advanced software development tools, cloud-based systems, and collaboration platforms.

  • May require extended hours during major project deadlines, production incidents, or strategic initiatives.

  • Operates with significant independence and responsibility; expected to provide leadership on complex technical and organizational decisions.

The expected, full-time, annual base pay scale for this position is $169k-224k in the bay area. 

This role may be eligible for other forms of compensation, including an annual bonus and/or incentives, subject to the terms of the applicable plans and Company discretion. This range reflects a good-faith estimate of the range that the Company reasonably expects to pay for the position upon hire; the actual compensation offered may vary depending on factors such as the candidate’s qualifications. Employees in this role are also eligible for GRAIL’s comprehensive and competitive benefits package, offered in accordance with our applicable plans and policies. This package currently includes flexible time-off or vacation; a 401(k) retirement plan with employer match; medical, dental, and vision coverage; and carefully selected mindfulness programs.

GRAIL is an equal employment opportunity employer, and we are committed to building a workplace where every individual can thrive, contribute, and grow. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, gender, gender identity, sexual orientation, age, disability, status as a protected veteran, , or any other class or characteristic protected by applicable federal, state, and local laws. Additionally, GRAIL will consider for employment qualified applicants with arrest and conviction records in a manner consistent with applicable law and provide reasonable accommodations to qualified individuals with disabilities. Please contact us at [email protected] if you require an accommodation to apply for an open position.

GRAIL maintains a drug-free workplace. We welcome job-seekers from all backgrounds to join us!

Skills Required

  • Bachelor's degree in Computer Science, Software Engineering, or related field
  • Master's or PhD in relevant field
  • 8-12 years of relevant software development experience with technical leadership
  • Advanced proficiency in multiple programming languages and frameworks (Java, Python, C#, C++, JavaScript/TypeScript)
  • Deep understanding of software architecture, distributed systems, and cloud-based environments (AWS, Azure, GCP)
  • Experience designing and delivering complex, high-scale, mission-critical systems
  • Strong background in databases, system integration, security, and API development
  • Proficiency with CI/CD pipelines, DevOps practices, and agile development methodologies
  • Knowledge of cybersecurity principles and control frameworks (ISO 27001, NIST, SOC 2, HIPAA)
  • Knowledge of regulatory requirements for regulated medical device environments (IVDD, IVDR, FDA 21 CFR 800 series, FDA 21 CFR Part 11)
  • Demonstrated mentoring, leadership, communication, and strategic planning abilities

What the Team is Saying

Neda Ronaghi
Ruth Mauntz
Tristan Matthews
David Jenions
Satnam Alag

GRAIL Compensation & Benefits Highlights

  • Healthcare Strength Comprehensive medical, dental, vision, and mental‑health resources are offered, with FSAs/HSAs and multiple carrier options. Feedback suggests the company covers a large share of premiums, enhancing perceived value.
  • Leave & Time Off Breadth Flexible/“unlimited” time off, sick time, paid holidays, and summer/winter shutdowns provide broad time‑off options. Hybrid/remote work further expands flexibility for many roles.
  • Equity Value & Accessibility An ESPP with a discounted purchase feature and equity grants provide accessible ownership upside confirmed by company filings. Feedback suggests equity is a meaningful part of total rewards.

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The Company
HQ: Menlo Park, CA
918 Employees
Year Founded: 2016

What We Do

GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is using the power of high-intensity sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop and commercialize pioneering products.

Why Work With Us

Everything we do is guided by our mission to detect cancer early, when it can be cured. It’s the reason we’re here, and it’s no small task. The right people make all the difference. That’s why we’re looking for those who strive to share their knowledge, contribute their skills, inspire each other and commit to something bigger than themselves.

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GRAIL Offices

Hybrid Workspace

Employees engage in a combination of remote and on-site work.

GRAIL has a variety of work types depending on the roles. Some roles are onsite like a lab role, some are fully remote like our Galleri Sales Consultant roles. Others are hybrid with 2-3 days onsite. Typically Tuesday and Thursday.

Typical time on-site: 2 days a week
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HQMenlo Park, CA
Company Office Image
London, GB
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Raleigh, NC
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Washington, DC
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