Passionate about precision medicine and advancing the healthcare industry?
Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.
We are seeking a Senior Software Engineer to help design, build, and scale high-quality software systems at Tempus. This role is ideal for an experienced engineer who can work across the stack, contribute to architecture and design, improve engineering quality, and collaborate effectively across teams to deliver reliable products and services. Come help our team build AI-integrated applications and data pipelines powering our next-generation health data abstraction platform, enabling us to scale data analysis and unlock critical insights from patient records.
Key ResponsibilitiesDesign, build, and maintain scalable web applications and backend services.
Plan and deliver new services and features from front end to back end.
Write clean, efficient, and maintainable code that performs reliably at scale.
Contribute to and document thoughtful software design and architecture decisions.
Improve code quality through meaningful code reviews and engineering best practices.
Debug and resolve issues in existing systems, including problems spanning multiple services.
Build and maintain automated data flows using pipelines and scripts.
Write automated unit, integration, and system tests.
Manually test code thoroughly, including edge cases and failure scenarios.
Identify and address team-wide engineering challenges to elevate the broader team.
Partner with cross-functional and adjacent teams to improve products and resolve issues.
Professional-level knowledge of application programming languages such as Python, TypeScript, or Java, as well as SQL.
Professional-level experience in web application development.
Demonstrated ability to build software that is scalable, maintainable, and high performing.
Experience contributing to software design, system architecture, and technical documentation.
Strong debugging and problem-solving skills across distributed or multi-service systems.
Experience writing automated tests across multiple layers of the application stack.
Commitment to code quality, testing, and engineering excellence.
Professional-level knowledge of TypeScript, React, and Node.js.
Familiarity with AI-enhanced coding tools.
Experience building and automating data pipelines and scripting workflows.
Track record of improving team practices and helping other engineers succeed.
You consistently deliver robust, scalable features across the stack.
You improve system quality through strong design, testing, and code review practices.
You help the team move faster by solving recurring engineering problems.
You collaborate effectively across teams to improve product quality and reliability.
CHI: $110,000-$160,000
NYC: $125,000-$175,000
The expected salary range may vary for other locations. Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.
We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Skills Required
- Professional-level knowledge of application programming languages such as Python, TypeScript, or Java, as well as SQL.
- Professional-level experience in web application development.
- Demonstrated ability to build software that is scalable, maintainable, and high performing.
- Experience contributing to software design, system architecture, and technical documentation.
- Strong debugging and problem-solving skills across distributed or multi-service systems.
- Experience writing automated tests across multiple layers of the application stack.
- Commitment to code quality, testing, and engineering excellence.
- Professional-level knowledge of TypeScript, React, and Node.js.
- Familiarity with AI-enhanced coding tools.
- Experience building and automating data pipelines and scripting workflows.
- Track record of improving team practices and helping other engineers succeed.
What the Team is Saying
Tempus AI Compensation & Benefits Highlights
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Healthcare Strength — Medical, dental, and vision insurance are standard and employer‑verified, complemented by life/disability coverage, HSA/FSA, mental health resources, and EAP. Company materials and verified listings indicate these core benefits are well established as of mid‑2026.
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Leave & Time Off Breadth — Vacation/Paid Time Off, Sick Leave, and Paid Holidays are explicitly offered on employer‑verified pages. Many roles are described as having flexible or unlimited PTO, though laboratory staff may follow separate policies.
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Wellbeing & Lifestyle Benefits — On‑site conveniences such as a cafeteria, stocked kitchens, and an on‑site barista are highlighted for select offices, alongside wellness initiatives, gym discounts, commuter benefits, and charitable matching. These day‑to‑day perks are emphasized on official culture/benefits pages and aligned third‑party summaries.
Tempus AI Insights
What We Do
We bring together one of the world’s largest libraries of multimodal clinical and molecular data with a robust suite of AI tools to help physicians personalize care in real time, connect patients with therapies and clinical trials, and enable partners to accelerate discovery and development of new treatments. With ~8 million de-identified research records and 350+ petabytes of data, Tempus partners with more than half of U.S. oncologists and the majority of the top 20 global pharma companies. Our teams are pioneering work across oncology, neurology, psychiatry, cardiology, and beyond—transforming how care is delivered and therapies are developed. At Tempus, every role contributes to our mission: to help each patient benefit from the experiences of those who came before. For more information, visit tempus.com.
Why Work With Us
We’re looking for people who can change the world. People who question the status quo and refuse to shy away from tough problems. For builders who are never done building, and the learners who are never done learning. Passionate individuals with undying curiosity who want to take on one of the greatest challenges humanity has ever faced—head on.
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Tempus AI Offices
Hybrid Workspace
Employees engage in a combination of remote and on-site work.
Most of the team follows a hybrid policy, with some roles allowing for a fully remote arrangement and some roles being onsite only.
