Principal Researcher/Associate Scientist, Bioanalysis and DMPK – Genetics Guided Dementia Discovery

At Eisai, satisfying unmet medical needs and increasing the benefits healthcare provides to patients, their families, and caregivers is Eisai’s human health care (hhc) mission. We’re a growing pharmaceutical company that is breaking through in neurology and oncology, with a strong emphasis on research and development. Our history includes the development of many innovative medicines, notably the discovery of the world's most widely-used treatment for Alzheimer’s disease. As we continue to expand, we are seeking highly-motivated individuals who want to work in a fast-paced environment and make a difference. If this is your profile, we want to hear from you.

The primary role of the Principal Researcher/Associate Scientist - DMPK is a highly qualified multi-disciplinary team-oriented researcher with emphasis in the area of LC-MS/MS based bioanalytical, in vitro ADME assays technologies. The major role of this position would be responsible for developing bioanalytical methods and conducting in vitro ADME studies to support discovery projects. Additional duty will include workflow logistics, such as interaction with internal/external collaborators, prepare paperwork, track study status, review data and upload data into database.

• Develop bioanalytical methods for quantitative analysis of small molecules in vivo study samples using LC-MS/MS. Operate and maintain instruments independently with adequate ability of troubleshooting. Analyze and report Pharmacokinetic data from in house PK or PD studies.
• Conduct various in vitro ADME experiments, including but not limited to metabolic stability studies using hepatocytes and/or microsomes, CYP inhibition/TDI, plasma protein binding, and reaction phenotyping, etc. Analyze raw data and report relevant parameters for in vitro DMPK assays in a timely fashion.
• Communicate research results to supervisor, process data, summarize in report format and upload into database in a timely manner.
• Maintain laboratory notebook and complete all documentation according to the standard operating procedures.
• Involve in comprehensive mechanistic ADME studies and author scientific manuscript for publication purpose as needed.
• Maintain smooth workflow with internal/external collaborators. Prepare paperwork, sample/compound shipment, track study status, review data and upload data into database.

• Monitor studies, review and QC data at external CRO partners.
 

Job Qualifications

• B.S. in Biology, Chemistry, Pharmaceutical Sciences or other related field with over 5 years’ experience or M.S. with 2+years of experience in industrial or relevant field.
• Must have direct working experience and knowledge with in vitro ADME studies and analytical techniques (UPLC/HLPC and Triple Quad/TOF Mass Spectrometry) with small molecules.

• Must demonstrate capability to follow SOPs and assay protocol and data integrity.

• Experience with bioanalysis of antibody and/or ASOs using ligand binding assay (LBA, ELISA) is a plus.

• Familiar with standard data analysis software packages used in the industry such as Excel, GraphPad, Phoenix or other similar software packages.
• Familiar with electronic notebooks.
• Mechanistic DMPK knowledge background is a plus.
• Ideal candidate should be someone who is self-motivated, eager to explore and learn new skills, and is able to work productively and cohesively in a team environment.
• Excellent written and oral communication skills.

Eisai Salary Transparency Language:

The base salary range for the Principal Researcher/Associate Scientist, Bioanalysis and DMPK – Genetics Guided Dementia Discovery is from :81,200-106,600

Under current guidelines, this position is eligible to participate in : Eisai Inc. Annual Incentive Plan.

Final pay determinations will depend on various factors including but not limited to experience level, education, knowledge, and skills.

Employees are eligible to participate in Company employee benefit programs. For additional information on Company employee benefits programs, visit https://us.eisai.com/careers-at-eisai/benefits.

Certain other benefits may be available for this position, please discuss any questions with your recruiter.

Eisai is an equal opportunity employer and as such, is committed in policy and in practice to recruit, hire, train, and promote in all job qualifications without regard to race, color, religion, gender, age, national origin, citizenship status, marital status, sexual orientation, gender identity, disability or veteran status. Similarly, considering the need for reasonable accommodations, Eisai prohibits discrimination against persons because of disability, including disabled veterans.

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