Company Overview
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Summary:
Tango Therapeutics is seeking a Manager, Total Rewards to help design, deliver, and continuously enhance our compensation, benefits, and rewards programs. Reporting to the Senior Director, Total Rewards & HR Operations, this role will serve as a strategic partner across the organization, ensuring our programs are competitive, equitable, scalable, and aligned with Tango's mission and growth.
This position will lead key compensation initiatives while also owning the administration and evolution of Tango's health, welfare, retirement, leave, wellness, and recognition programs. The role will partner closely with Talent Acquisition, Finance, and external vendors to deliver best-in-class employee experience that supports our ability to attract, retain, and engage top talent
Your Role:
- Manage and evolve Tango's compensation and job leveling framework
- Conduct market benchmarking and salary surveys to support competitive pay decisions
- Partner with Talent Acquisition on job pricing, offer development, and compensation guidance for new hires
- Partner with annual compensation planning, merit, bonus, equity, and promotion processes
- Manage Tango's employee benefits programs, including medical, dental, vision, retirement, leave of absence, wellness, and other reward offerings
- Partner with brokers and vendors to evaluate plan performance, analyze utilization and cost trends, and recommend enhancements that support employee well-being and business objectives
- Lead benefit renewals, open enrollment, employee communications, and ongoing vendor management
- Ensure compliance with applicable compensation and benefits regulations, including pay transparency and pay equity requirements
- Manage employee recognition and reward programs, including spot awards and milestone recognition
- Leverage market data and compensation tools, including Radford, to provide actionable insights to leaders
- Support and optimize HR systems and Total Rewards processes to improve efficiency and employee experience
- Develop and deliver compensation, benefits, and workforce analytics to support leadership decision-making, measure program effectiveness, identify trends, and inform strategic Total Rewards initiatives
What You Bring:
- Bachelor's degree and 5+ years of Human Resources experience, with a focus on Compensation, Benefits, or Total Rewards
- Experience supporting a fast-paced biotech, life sciences, or high-growth organization
- Strong knowledge of compensation programs, market pricing, salary surveys, and job architecture
- Experience managing employee benefits programs, broker relationships, open enrollment, and vendor partnerships
- Familiarity with regulatory requirements related to compensation and benefits administration
- Proficiency with compensation data sources such as Radford and compensation benchmarking methodologies
- Strong analytical, problem-solving, and communication skills
- Ability to build trusted partnerships across HR, Finance, Talent Acquisition, and business leadership
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
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Skills Required
- Bachelor's degree
- 5+ years of Human Resources experience focused on Compensation, Benefits, or Total Rewards
- Experience supporting a fast-paced biotech, life sciences, or high-growth organization
- Strong knowledge of compensation programs, market pricing, salary surveys, and job architecture
- Experience managing employee benefits programs, broker relationships, open enrollment, and vendor partnerships
- Familiarity with regulatory requirements related to compensation and benefits administration
- Proficiency with Radford and compensation benchmarking methodologies
- Strong analytical, problem-solving, and communication skills
- Ability to build trusted partnerships across HR, Finance, Talent Acquisition, and business leadership
What We Do
Tango Therapeutics is a biotechnology company discovering and developing novel medicines targeting cancer vulnerabilities to deliver transformational new therapies for patients. Tango was launched in 2017 with a $55 million Series A investment from Third Rock Ventures. The company has established a robust product engine that leverages advances in DNA sequencing and CRISPR-based target discovery to generate breakthrough medicines that have the potential to provide deeper, more sustained benefit than today’s targeted therapies, and extend the benefit of available immuno-oncology agents. Tango Therapeutics is focused on three areas of drug development, each in well-defined patient populations currently lacking effective treatment options, and each with hallmarks of cancer that have not been targeted yet. These include: loss of tumor suppressor gene function; multiple oncogenic drivers; and immune evasion. What fuels each of Tango’s programs is an increasingly sophisticated ability to utilize synthetic lethality - the interaction between two genes that causes cell death when both are inactivated. In cancer cells, one of these genes is inactivated by mutation; the other will be inactivated by a drug. This approach leaves normal cells largely unaffected, with the potential to greatly enhance anti-tumor efficacy and reduce associated toxicity. Tango’s success will be driven by its depth of understanding of the genetic subtypes of cancer, and corresponding insights into novel drug targets and combinations uniquely relevant to each subtype. By shaping discovery efforts in this way, Tango has the potential to reach the clinic quickly, and with a clear plan for identifying the patients most likely to benefit from each new treatment, an approach that could increase both speed and probability of success in translating novel target discoveries into transformational new medicines for patients.
