Jobs at Tango Therapeutics

Lead medical and scientific strategy for oncology development programs from early-stage through registration. Oversee protocol design, medical monitoring, safety review, regulatory submissions (IND/CTA/NDA/MAA), cross-functional team leadership, investigator and KOL engagement, clinical data analysis, and communication of results to regulators and scientific audiences.

Lead design, maintenance, and continuous improvement of the QMS across GxP domains. Oversee document lifecycle, change control, training frameworks, data integrity, metrics, CAPA prevention, audit readiness, and prepare quality review packages while partnering with functional owners to ensure compliance and effectiveness.

Lead clinical development strategy for TNG456, oversee protocol and regulatory filings, drive cross-functional execution, mentor medical staff, manage investigator and KOL relationships, support clinical trial operations, and represent the company externally at scientific forums.

Lead operational execution of clinical trials, manage CRO/vendor oversight, maintain trial systems and documentation, ensure inspection readiness, support budgeting and supply logistics, and coordinate cross-functional teams to meet timelines and regulatory requirements.

Lead and mentor a team of Clinical Scientists and provide scientific leadership for oncology clinical programs. Oversee design, execution, analysis, and interpretation of clinical trials; author and review key clinical and regulatory documents; partner cross-functionally on safety, PK/PD, biomarkers, and regulatory interactions; establish best practices and ensure scientific rigor across clinical development.

Lead biostatistics for oncology clinical programs: design and analyze trials, author/review SAPs and statistical sections, oversee CRO deliverables and QC, support regulatory submissions and agency interactions, and drive biostatistics process and methodology improvements.

Lead clinical development strategy for vopimetostat from early through late stage, oversee study design and execution, regulatory interactions, data interpretation, and mentor Medical Directors/Clinical Scientists while partnering cross-functionally and representing the program externally.

Manage clinical biosample lifecycle for multiple trials: coordinate shipments, oversee chain of custody, integrate inventory into LIMS, perform audits, resolve sample queries, and ensure GCP/GCLP compliance with internal and external stakeholders.