Jobs at Tango Therapeutics

Provides GMP Quality Assurance oversight for CMC development programs and clinical supplies. Reviews batch records and disposition materials, manages quality activities, ensures global GMP compliance, supports investigations and documentation approval, identifies quality trends, audits CMOs and laboratories, and advises cross-functional teams on regulatory compliance and inspection readiness.

Leads commercial strategy and execution for portfolio and country initiatives, including launch readiness, commercialization planning, sales and marketing operations, and commercial capability development. Partners with cross-functional teams across R&D, market access, regulatory, finance, medical affairs, supply chain, and manufacturing. Monitors market and competitive trends, supports strategic alliances, and drives operational excellence. Requires extensive biotech or pharmaceutical commercial experience, oncology expertise, and knowledge of FDA promotional regulations and drug development.

Leads the enterprise market access strategy for a biotechnology company transitioning to commercial operations. Builds global value, pricing, payer strategy, patient services, specialty pharmacy distribution, trade operations, and HEOR capabilities. Oversees launch access for oral oncology therapies, develops pricing and contracting frameworks, anticipates healthcare policy changes, optimizes government pricing, and advises executive leadership on commercial value and patient access.

Leads Tango Therapeutics’ enterprise Insights and Analytics center of excellence, shaping data, analytics, market research, competitive intelligence, forecasting, and commercial strategy for oncology medicine launches and lifecycle management. Partners with executive and cross-functional leadership, oversees pharmaceutical data integration and governance, builds predictive analytics and dashboarding capabilities, and develops high-performing analytics teams supporting Sales, Marketing, Market Access, Medical Affairs, Finance, and Clinical Development.

Leads enterprise commercial strategy, marketing, sales infrastructure, and launch readiness for Tango Therapeutics’ precision oncology assets. Builds the commercial organization, develops disease and brand positioning, directs omnichannel engagement and market intelligence, designs the specialized oncology field force, and cultivates relationships with oncologists, academic networks, and community practices. Partners cross-functionally with clinical development, regulatory, medical affairs, finance, and corporate communications to align commercialization with corporate strategy.

Leads clinical informatics strategy and delivery across clinical development programs, including data flows, integrations, analytics, dashboards, IRT, and eCOA systems. Oversees vendors, configurations, testing, validation, data governance, regulatory compliance, audits, and inspection readiness in a GxP environment. Partners with clinical, data management, biostatistics, and drug supply teams to implement scalable solutions, automation, interoperability, and advanced analytics.

Leads enterprise-wide FP&A strategy, annual operating plans, reforecasts, long-range planning, clinical trial forecasting, cash runway modeling, scenario analysis, and executive and board reporting. Partners with Clinical Operations, Global Program Teams, R&D, Commercial, Accounting, and corporate development. Builds scalable financial processes and systems, supports pre-commercial finance, and leads and develops the FP&A team.

Manage and enhance compensation, benefits, job leveling, benchmarking, annual pay planning, equity, bonuses, leave, wellness, recognition, and vendor programs. Partner with Talent Acquisition, Finance, HR, brokers, and business leaders on competitive and compliant rewards strategies. Lead renewals, open enrollment, employee communications, workforce analytics, and HR process improvements while supporting employee attraction, retention, and engagement.

Leads GCP and GLP quality assurance across clinical and nonclinical programs. Responsibilities include risk-based audits, CRO and vendor oversight, inspection readiness, quality-event investigations, root-cause analysis, CAPA development, quality agreements, SOPs, training, and regulatory inspection responses. The role provides strategic QA guidance to Clinical Operations, clinical trial teams, nonclinical groups, and external partners while ensuring compliance with global regulations and FDA BIMO requirements.

Leads pharmacovigilance and drug safety activities across clinical development and commercialization. Responsibilities include signal detection, literature reviews, benefit-risk assessments, safety governance, aggregate safety report authorship, clinical document review, risk management, regulatory compliance, audits, inspections, and collaboration with cross-functional and partner teams.

Lead medical and scientific strategy for oncology development programs from early-stage through registration. Oversee protocol design, medical monitoring, safety review, regulatory submissions (IND/CTA/NDA/MAA), cross-functional team leadership, investigator and KOL engagement, clinical data analysis, and communication of results to regulators and scientific audiences.

Lead design, maintenance, and continuous improvement of the QMS across GxP domains. Oversee document lifecycle, change control, training frameworks, data integrity, metrics, CAPA prevention, audit readiness, and prepare quality review packages while partnering with functional owners to ensure compliance and effectiveness.

Lead clinical development strategy for TNG456, oversee protocol and regulatory filings, drive cross-functional execution, mentor medical staff, manage investigator and KOL relationships, support clinical trial operations, and represent the company externally at scientific forums.

Lead and mentor a team of Clinical Scientists and provide scientific leadership for oncology clinical programs. Oversee design, execution, analysis, and interpretation of clinical trials; author and review key clinical and regulatory documents; partner cross-functionally on safety, PK/PD, biomarkers, and regulatory interactions; establish best practices and ensure scientific rigor across clinical development.

Lead biostatistics for oncology clinical programs: design and analyze trials, author/review SAPs and statistical sections, oversee CRO deliverables and QC, support regulatory submissions and agency interactions, and drive biostatistics process and methodology improvements.

Lead clinical development strategy for vopimetostat from early through late stage, oversee study design and execution, regulatory interactions, data interpretation, and mentor Medical Directors/Clinical Scientists while partnering cross-functionally and representing the program externally.

Manage clinical biosample lifecycle for multiple trials: coordinate shipments, oversee chain of custody, integrate inventory into LIMS, perform audits, resolve sample queries, and ensure GCP/GCLP compliance with internal and external stakeholders.