Conjugation Scientist, Biotherapeutic Engineering (BS or MS)

Job Description Summary

Internal Title: Senior Scientist I
#LI-Onsite lab role
The Biologics Research Center (BRC) is seeking a highly motivated scientist with the skills and experience to contribute to advancing ADC drugs to patients in need. This is a great opportunity to join a group dedicated to protein, antibody drug/ antibody drug conjugate discovery. In this role, you will be a member of several multidisciplinary teams in a variety of disease areas, you will support the Novartis conjugation core and be a key player in advancing drug discovery projects.
*A proven track record of hands-on experience with conjugation chemistry and analytical assays are essential for this role*

Job Description

Key Responsibilities:

• Independently conjugate, purify and characterize antibody-drug and/or oligonucleotide conjugates (ADCs/AOCs) using applicable instrumentation for linker-payload conjugation and purification, analytical techniques and characterization assays
• Coordinate the submission for supplementary biophysical characterization and interpret analytical results with area experts.
• Contribute to the analysis and synthesis of results, design of new experiments and clear communication of scientific progress to project team(s); troubleshoot experiments, optimize conjugation protocols and suggest mitigation strategies to meet project accelerated timelines.
• Work effectively as a member of cross-functional teams to accomplish shared project goals.
• Contemporaneous and accurate documentation of experiments in ELN and registration databases
• Contribute to patents, publications, and technical reports

Essential Requirements:

• This is not a PhD level position
• Independently conjugate, purify and characterize antibody-drug and/or oligonucleotide conjugates (ADCs/AOCs) using applicable instrumentation for linker-payload conjugation and purification, analytical techniques and characterization assays
• Coordinate the submission for supplementary biophysical characterization and interpret analytical results with area experts.
• Contribute to the analysis and synthesis of results, design of new experiments and clear communication of scientific progress to project team(s); troubleshoot experiments, optimize conjugation protocols and suggest mitigation strategies to meet project accelerated timelines.
• Work effectively as a member of cross-functional teams to accomplish shared project goals.
• Contemporaneous and accurate documentation of experiments in ELN and registration databases
• Contribute to patents, publications, and technical reports

Desirable Requirements:

• Proficiency in any of the following: antibody engineering and characterization
• Experience with expressing, purifying and characterizing hybridomas and recombinant antibodies
• Extended molecular biology expertise in assays such as cloning and qPCR
• Experience in cell binding and functional assays for antibody/ ADC/AOC characterization
• Experience with biological assays such as measuring cytotoxic activity for ADC characterization
• Ability to analyze experiments in related software such as Microsoft Excel, including basic macro programing; FlowJo; Octet etc.

Company will not sponsor visas for this position.

Novartis is unable to offer relocation support for this role: please only apply if this location is accessible for you.

Novartis Compensation and Benefit Summary:

The pay range for this position at commencement of employment is expected to be between: $85,400 and $158,600/year; however, while salary ranges are effective from 1/1/25 through 12/31/25, fluctuations in the job market may necessitate adjustments to pay ranges during this period.  Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

EEO Statement:

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. 

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Salary Range

$85,400.00 - $158,600.00

Skills Desired

Analytical Skill, Analytical Skill, Analytical Thinking, Chemical Biology, Chemistry, Clinical Research, Clinical Trials, Collaboration, Communication Skills, Curiosity, Data, Data Analysis, Design Of Experiments, Detail-Oriented, Diversity & Inclusion, Drug Discovery, Ethics, Gene Therapy, Immunology, Laboratory, Lifesciences, Machine Learning (Ml), Mammalian Cell Culture, Medical Research, Molecular Biology {+ 11 more}