Jobs at Flagship Pioneering

Owns FL113’s initial commercial and go-to-market motion, from prospecting and customer discovery through pilot scoping, negotiations, deployment, and conversion to enterprise agreements. Targets biopharma, health systems, ACOs, and payers; develops pricing, packaging, positioning, and partnership strategies; and builds repeatable sales infrastructure, including CRM, pipeline reporting, deal reviews, and playbooks. Partners with clinical, product, data science, security, privacy, legal, and finance stakeholders to translate customer needs into commercial growth.

Own and extend production automation for Microsoft 365 and Entra ID across a complex multi-company tenant. Maintain identity lifecycle processes, Exchange Online and SharePoint Online automation, integrations, access governance, authentication, monitoring, and CI/CD practices. Troubleshoot and refactor existing code, support organizational lifecycle events, improve security and reliability, document solutions, and serve as a senior escalation point while mentoring peers.

Build and operate secure AWS backend systems, healthcare data pipelines, and EHR integrations that transform partner data into model-ready results. Develop FHIR integrations, AI-assisted onboarding tools, infrastructure, CI/CD, monitoring, and production ML operations while supporting product and full-stack needs. Lead partner technical go-lives, establish engineering standards, mentor future engineers, and collaborate with data scientists, clinicians, and IT teams while protecting PHI.

The Associate Director, Accounting will build and lead ProFound Therapeutics’ accounting function, overseeing close, U.S. GAAP reporting, technical accounting, controls, audit readiness, NetSuite OneWorld, tax coordination, treasury support, and outsourced providers. The role will establish scalable policies, systems, and processes; manage collaboration, licensing, grant, equity, debt, and R&D accounting; support financing and board reporting; and develop the accounting team and automation roadmap.

Design, build, and own scalable data infrastructure for proteomics research and machine learning. Responsibilities include developing production data platforms and pipelines, integrating instruments and LIMS, creating cloud infrastructure with infrastructure-as-code and CI/CD, ensuring data integrity and lineage, and transforming raw experimental data into reliable ML-ready datasets. The role partners closely with scientific teams, establishes engineering standards, sets technical direction, and mentors colleagues.

Build and evaluate machine learning models that predict genetic variant effects on protein function and interpret somatic selection signals for drug target discovery. Develop AI agents and workflows for evidence retrieval, analysis, hypothesis testing, and target assessment. Train or adapt foundation models, collaborate with computational and experimental teams, maintain tested and reproducible code, and communicate technical findings to scientific and leadership audiences.

Lead product strategy and execution for Iris Chat, an AI-powered psychological fitness product. Own product vision, customer journeys, activation, retention, conversion, subscription value, experimentation, and AI quality. Manage product, design, engineering, and AI research teams; hire and develop leaders; balance research and delivery; and establish standards for evaluation, privacy, safety, reliability, and user trust. Partner with leadership to build a focused roadmap and durable consumer business.

Develop evolutionary algorithms for autonomous scientific discovery, enabling populations of models, hypotheses, programs, and representations to evolve through iterative search, selection, evaluation, and recombination. Build Bayesian and probabilistic methods for candidate ranking, uncertainty estimation, diversity preservation, and quality measurement. Establish benchmarks, integrate algorithms into autonomous-science pipelines, publish research, guide technical direction, and mentor colleagues as a senior individual contributor.

Lead full‑stack development of customer‑facing features, own product lifecycle from design to release, build scalable AI‑enabled back‑end systems on AWS, improve CI/CD and testing, collaborate with product, design, and ML researchers, and ensure security and privacy best practices.

Leads product safety and wellbeing strategy for AI-powered experiences. Owns safety roadmaps, guardrails, evaluation frameworks, benchmarks, metrics, monitoring, launch-readiness criteria, and human or automated evaluation programs. Assesses failure modes and emerging risks, including self-harm and crisis scenarios, and translates expert and user findings into product guidance. Partners with engineering, machine learning, product, design, and data science teams to improve risk detection, response generation, escalation, and user experience.

Own international accounting, compliance, financial close, statutory reporting, audits, tax filings, consolidations, and intercompany transactions for multiple subsidiaries. Manage outsourced providers, support UK equity compensation and international billing, coordinate new entity setup, and oversee financial reporting for a government contracting entity. Partner with Legal, HR, Treasury, Tax, Compensation, portfolio companies, auditors, and government-contracting advisors across jurisdictions.

Leads the design, implementation, and optimization of cloud-native data infrastructure, platforms, storage solutions, and complex data pipelines. Establishes engineering standards for testing, monitoring, releases, and reliability; troubleshoots cross-system failures and leads incident reviews. Partners with infrastructure, laboratory IT, data science, bioinformatics, and scientific teams to deliver secure, scalable solutions. Mentors engineers, guides technical initiatives, and uses generative AI to accelerate development and data transformation.

Build and operationalize Flagship Pioneering’s compliance program for government contracts, grants, fund operations, and international activities. Responsibilities include developing policies, controls, training, monitoring, reporting, remediation, regulatory assessments, investor and conflicts compliance, escalation processes, and global standards. The role partners with Finance, Contracts, outside advisors, and portfolio companies while transitioning compliance capabilities in-house and applying AI legal tools to improve efficiency.

Build and deploy AI-powered tools and workflows for legal operations, including contract review, research, drafting, compliance, and knowledge management. Develop prompt frameworks, integrations, governance controls, quality procedures, and responsible-use policies. Evaluate vendors, assess technical and security risks, train legal teams, document workflows, track adoption and ROI, and collaborate with attorneys, IT, privacy, security, and business stakeholders.

Develop and execute internal communications strategies across Flagship’s ecosystem of 40+ companies. Create content for intranet, newsletters, email, messaging platforms, digital signage, executive communications, and events. Manage editorial calendars, campaigns, governance, and communication analytics while partnering with leadership, HR, and functional teams. Support employee engagement, onboarding, culture-building, change management, and crisis communications through clear, compelling storytelling and strategic guidance.

Lead the full lifecycle of data science models that predict and optimize advertising performance across channels. Define learning targets, build training data, develop forecasting and causal measurement systems, design experiments, validate models, and translate outputs into customer-facing recommendations. Partner with product, engineering, data, and customer teams to deploy models, assess uncertainty and drift, and demonstrate measurable business impact.

Transactions Counsel supporting venture financings, capital markets, M&A, corporate governance, equity issuances, partnerships, and other complex transactions across Flagship’s portfolio companies. Responsibilities include drafting and negotiating transaction documents, conducting legal research, advising finance and portfolio teams, managing outside counsel, supporting compliance, standardizing legal processes, and driving multiple high-volume deals to completion.

The Operating Principal will lead operations and strategy in biotech firms, focusing on corporate development, team management, and aligning scientific goals with business objectives.

Lead the scientific direction and machine learning development for climate modeling. Manage model training, evaluation, and collaboration across teams to develop predictive systems based on hydrology and climate data.

The VP of Finance will advise portfolio companies on financial strategy, oversee day-to-day operations, manage cash flow, and prepare financial materials for governance meetings.