Jobs at Flagship Pioneering

Lead and execute company-wide data, software, ML/AI and IT strategy. Build and manage a multidisciplinary team, establish data architecture and governance, deploy production software and ML workflows, oversee bespoke development and IT services, and partner with scientific teams to ensure secure, reliable, and FAIR data-driven operations.

Lead multiple AI/ML computational projects across early-stage ventures, define AI strategy, oversee method and pipeline development (including protein design, docking, LLM agents), ensure benchmarking/scaling/productionization, mentor and manage cross-functional teams, scout literature, and represent the organization to partners and conferences.

Lead architecture and implementation of AI-powered scientific products end-to-end. Design data models, APIs, deployment, observability, and maintainability. Collaborate with scientists and ML researchers, make high-stakes technical decisions, bridge research and production ML, and occasionally direct embedded contractors while owning technical output and quality.

Lead full‑stack development of customer‑facing features, own product lifecycle from design to release, build scalable AI‑enabled back‑end systems on AWS, improve CI/CD and testing, collaborate with product, design, and ML researchers, and ensure security and privacy best practices.

Lead DMPK strategy for biologics across discovery and development: design and interpret PK/BA/immunogenicity studies, guide candidate selection and dose projections, author regulatory DMPK/BA sections, oversee CROs, and collaborate with cross-functional teams and PK/PD modelers to ensure regulatory readiness.

Partner with the CEO to translate corporate strategy into operating plans, drive execution of high-priority initiatives (financing, in-/out-licensing), coordinate cross-functional workstreams, build operating rhythms, support corporate development and partnerships, and provide executive reporting and decision-support to ensure timely delivery and organizational alignment.

Develop and deploy LLM-powered ML applications for psychological wellbeing. Collaborate with psychologists to translate insights into computational systems, advance RLHF and agentic AI methods, build scalable data and training pipelines, integrate ML systems into real-world products, and communicate results to multidisciplinary teams.

Lead complex, cross-functional IT initiatives from planning through implementation. Define scope and success metrics, manage schedules, budgets, risks, vendors, and governance. Drive stakeholder alignment, change management, delivery excellence, and mentor project leaders.

The Operating Principal will lead operations and strategy in biotech firms, focusing on corporate development, team management, and aligning scientific goals with business objectives.

The Senior Engineer, AI and Automation role involves designing AI-powered systems, maintaining infrastructure, building integrations, and establishing MLOps while collaborating with various teams on enterprise applications.

The Associate Director, AI Operations & Enablement leads AI strategy execution, education, and vendor management to enhance AI adoption and impact across the organization.

The Senior Research Associate will perform histopathological assessments, manage tissue sample workflows, and collaborate on method development for somatic genomics.

The VP of Finance will advise portfolio companies on financial strategy, oversee day-to-day operations, manage cash flow, and prepare financial materials for governance meetings.

Lead the scientific direction and machine learning development for climate modeling. Manage model training, evaluation, and collaboration across teams to develop predictive systems based on hydrology and climate data.

The Associate Director, AI Operations & Enablement will lead AI strategy execution, education, tool and vendor management, and promote AI adoption across the organization, collaborating with various stakeholders to drive measurable impact.

The Director of Program Management will drive R&D and corporate initiatives, ensuring alignment with company goals, managing cross-functional projects, and fostering communication among stakeholders.

The Contracts Attorney will draft, negotiate, and manage various contracts, support training on contract processes, advise stakeholders, and coordinate with departments to enhance contract workflows.

Lead design and implementation of talent management, leadership development, and organizational change frameworks. Partner with senior leaders to drive change, build career pathways, and run high-impact OD programs using talent technologies and people analytics. Manage multiple strategic initiatives, communications, and stakeholder alignment to scale organizational capability across the enterprise and portfolio companies.

Lead ideation, research, and validation of novel venture hypotheses; design experiments, assess IP, recruit KOLs and early teams, and build initial company strategy and operations. Drive lab setup, partnerships, and business development while translating scientific insight into executable plans and transitioning pressure-tested ideas into NewCos alongside senior venture leaders.

The Senior Accountant will manage month-end closes, develop accounting policies, conduct reconciliations, assist with budgets, and ensure compliance with GAAP, providing financial insights and reports.