AI and ML at Flagship Pioneering:
Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring entrepreneurial scientists together with experienced company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, technology and beyond. Artificial intelligence is core to how Flagship conceives and builds companies. We call our approach polyintelligence: human creativity and nature’s intelligence integrating and coexisting with artificial intelligence. This model runs across our ecosystem, where teams pair advances in AI and machine learning with foundational science to move from idea to concept faster and build AI-native companies that were previously out of reach.
Who we are looking for:
Computational scientists and engineers with broad interests and experience applying deep technical experience to out of distribution scientific questions. Standalone implementation isn’t the goal, it is creatively spotting opportunities where extension, modification and combination of bleeding edge computational and technical approaches can unlock new capabilities to solve consequential problems. Strong candidates will combine software engineering fundamentals with a readiness to embrace agentic development tools/practices and have experience implementing machine learning models and workflows across multiple model classes or scientific domains.
The Experience:
You will collaborate with Flagship Origination Teams and fellow ML scientists/engineers to explore what is made possible by big leaps beyond the current capabilities of AI. You will begin by asking ‘What if’ across a variety of ideas and building a ‘future backwards’ case for what needs to be true for them to become a reality. You will explore the tradeoffs across multiple options, including what and how much data is needed and where it might come from. You will work towards implementation and evaluation plans that enable us to address the real uncertainties, not just what is easy to measure.
With a project defined, you will begin to implement, evaluate and iterate. You will leverage Flagship's scalable GPU compute resources, data from our ecosystem, and the extensive expertise available across our teams. You will implement the benchmarking capabilities needed to measure what matters and evaluate your designs. We will learn along the way and be ready to pivot on methods. Final work products are never just a model or a paper, they are wholistic answers to the future backwards questions we ask ourselves when originating the next big leap company.
The pay range for this role is $7,000 - $9,000 per month. This role is a short-term engagement that is not eligible for health and welfare benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.
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Skills Required
- Computational science or engineering background
- Deep technical experience applying computational approaches to scientific questions
- Software engineering fundamentals
- Readiness to use agentic development tools and practices
- Experience implementing machine learning models and workflows across multiple model classes or scientific domains
Flagship Pioneering Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Flagship Pioneering and has not been reviewed or approved by Flagship Pioneering.
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Fair & Transparent Compensation — Feedback suggests salary bands are visible for many Boston/Cambridge roles and pay is considered competitive for key scientific and leadership positions. Transparency in postings supports expectations that offers align with local biotech norms.
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Healthcare Strength — Feedback suggests medical, dental, vision, disability, life insurance, HSA options, and mental-health coverage are comprehensive and well-regarded. Multiple items are employer-verified, reinforcing confidence in core health benefits.
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Parental & Family Support — Feedback suggests maternity/paternity leave and family leave are offered at meaningful levels. These programs sit alongside paid holidays, sick days, and PTO to support family needs.
Flagship Pioneering Insights
What We Do
Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique, hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $30 billion in aggregate value. To date, Flagship is backed by >$3 billion of aggregate capital commitments, of which over $1.5 billion has been deployed toward the founding and growth of its pioneering companies alongside >$10 billion of follow-on investments from other institutions. The current Flagship ecosystem includes Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Seres Therapeutics (NASDAQ: MCRB), and Syros Pharmaceuticals (NASDAQ: SYRS).







