Jobs at Dyne Therapeutics

Designs, synthesizes, purifies, characterizes, and optimizes protein, peptide, antibody, and oligonucleotide bioconjugates for therapeutic programs. Develops linker and site-specific conjugation strategies, analyzes experimental data, troubleshoots technical challenges, documents findings, and collaborates cross-functionally across chemistry, protein engineering, analytical sciences, biology, and process development. Supports technology innovation and transfer of conjugation processes to development and manufacturing teams.

Lead and oversee statistical programming across multiple clinical studies, ensuring CDISC-compliant datasets and TLFs, vendor coordination, submission readiness (eCTD), development of reusable tools/automation, mentoring junior staff, and contributing to departmental standards, processes, and strategy to support regulatory submissions and clinical decision-making.

The Director oversees and evolves the Quality Management System, embedding quality in operations and ensuring compliance with global regulations while managing audits and supplier quality.

Lead FP&A activities including budgeting, forecasting, financial modeling, variance and KPI analysis, and scenario planning. Own FP&A systems, reporting tools, and financial data warehouse development. Partner with Accounting, IT, and business leaders to deliver automated dashboards, actionable insights, and business cases supporting resource allocation, portfolio decisions, and board-level reporting.

Lead and execute HR operations strategy and day-to-day functions including onboarding, HRIS administration, benefits, compliance, vendor management, reporting, automation, and process improvement. Serve as HR technology and data governance owner, partner cross-functionally, manage immigration and benefits processes, and lead, coach, and scale the People Operations team to support growth and commercialization readiness.

The Senior Director of Program Management leads cross-functional teams in drug development, ensuring strategic alignment and execution while fostering collaboration and continuous improvement.

The Senior Director leads the development of reporting and analytics for clinical operations, integrating data for decision-making and optimizing resources using advanced analytics and AI.

Lead Talent Acquisition operations, systems, programs, and reporting to scale hiring. Own ATS and integrations, design recruiting processes and governance, improve candidate and hiring-team experience, drive TA analytics and dashboards, ensure compliance, manage vendors and budgets, and partner cross-functionally to implement TA technology, automation, and continuous process improvements.

Partnering directly with the CCO, lead high-priority commercial strategy and cross-functional initiatives, shape the commercial operating model, prepare executive and Board materials, and drive decision-making and execution to support launch and growth of rare-disease therapeutics.

Senior HR leader responsible for enterprise learning, leadership development, manager excellence, onboarding, succession planning, and workforce capability. Partners with executive teams to design scalable blended learning, measure impact with analytics, drive culture and change initiatives, and build a high-performing L&D function to support Dyne's growth.

Lead US commercial enablement by designing incentive compensation, optimizing CRM and BI systems, building field operations infrastructure, coordinating cross-functional launch readiness, and scaling processes to improve field effectiveness and operational excellence.

Lead generation of market, customer, and data-driven insights to inform commercial strategy across rare neuromuscular pipeline. Own global forecasting, market research, competitive intelligence, dashboards/KPIs, and advanced analytics. Partner cross-functionally to guide launch planning, access, budgeting, and executive decision-making while ensuring data governance and vendor management.

The Director of HCP Marketing leads strategies for engaging healthcare providers in Duchenne Muscular Dystrophy, focusing on launch execution, cross-functional collaboration, and utilizing insights for improved performance.

Lead Dynes enterprise procurement function, building source-to-pay strategy, processes, systems, and supplier management. Drive high-value sourcing, negotiations, compliance, cross-functional partnership, reporting on savings and risks, and CSR/ESG procurement initiatives to support growth and operational goals.

Lead design, scaling, and governance of a global, inspection-ready Quality Management System (QMS) supporting commercial readiness. Own document control, records management, training/eDMS/LMS, eQMS implementation, compliance with ICH/FDA/EU standards, inspection readiness, quality metrics, and cross-functional embedding of quality practices.

Lead global Quality Control for clinical and commercial programs, overseeing external labs, analytical operations, method qualification/validation, stability and release testing, OOS/OOT investigations, and regulatory CMC submissions. Build QC strategy and team capabilities, ensure cGMP compliance and inspection readiness, drive vendor performance and cross-functional alignment to support product disposition through BLA and commercialization.

Field-based Key Account Manager responsible for developing and executing account plans for priority hospital/academic accounts in rare neuromuscular diseases. Aligns cross-functional engagement (Commercial, Medical, Market Access, Patient Services, Advocacy) to improve patient access and adoption, builds stakeholder relationships, and supports regional strategy in a matrixed environment. Requires heavy travel and territory residency.

Field-based Key Account Manager responsible for developing and executing account plans for priority hospital/academic accounts. Builds tailored stakeholder engagement, coordinates cross-functional partners (Medical, Market Access, Advocacy), drives adoption across care pathways, analyzes market opportunities, and supports regional strategy execution. Heavy travel and territory residency required.

Field-based Key Account Manager responsible for account-level engagement and strategy for priority hospital/AMCs. Develops account plans, tailors stakeholder outreach, partners cross-functionally (Commercial, Medical, Market Access, Patient Services, Advocacy) to improve patient access and adoption. Operates within a regional matrix, provides account insights, and supports coordinated execution. Frequent regional and national travel required.

Field-based Key Account Manager responsible for developing and executing account plans for priority accounts in a defined territory. Builds stakeholder relationships, tailors engagement to clinical and operational decision-makers, collaborates with cross-functional partners (Medical, Market Access, Patient Services, Advocacy, Marketing), and supports compliant execution to improve patient access and adoption. Analyzes market dynamics, contributes regional insights, and prioritizes activities to optimize customer experience and launch goals. Up to 80% travel required.