Top Software Engineer Jobs in St. Louis, MO

Designs, develops, and integrates business applications across Dynamics 365, Power Platform, Azure, and custom Microsoft-stack solutions. Responsibilities include solution architecture, application customization, APIs and event-driven integrations, platform modernization, ALM, CI/CD, deployment pipelines, and production support. The role also establishes engineering standards, evaluates technologies, collaborates with technical and business teams, and mentors junior staff.

Principal Software Engineer leading architecture, development, and technical strategy for complex software platforms. The role requires designing scalable and secure systems, guiding engineering standards, mentoring engineers, resolving complex technical issues, and partnering with product, laboratory, and bioinformatics teams. Responsibilities include software architecture, React and .NET development, database optimization, REST APIs, distributed systems, DevOps, regulatory compliance, and long-term technology roadmaps supporting clinical and genomic workflows.

Develop and customize Salesforce solutions using Apex, Visualforce, Lightning, Aura, SOQL, JavaScript, and triggers. Configure Salesforce objects, workflows, reports, dashboards, security, and administration across Sales, Service, and Community Cloud. Build integrations using REST, SOAP, WSDL, and Salesforce APIs; manage data migration, testing, troubleshooting, and deployments. Collaborate with U.S.-based business and IT stakeholders while supporting production systems.

Designs, develops, tests, documents, maintains, and supports JD Edwards EnterpriseOne applications and environments. Responsibilities include unit testing, system monitoring, technical documentation, application troubleshooting, customer support, and coordinating development projects across IT. The role requires EnterpriseOne programming experience, development toolkit expertise, and familiarity with applications, UBEs, TCs, BSFNs, NERs, UDOs, and interfaces.

Lead and grow engineering teams building blockchain and Web3 products. Drive technical strategy, architecture, delivery, quality, hiring, mentoring, and engineering processes to ensure reliable product delivery and team scaling.

Build and ship full-stack product features across HR-facing and employee health insurance platforms. Partner directly with stakeholders, own product decisions, integrate LLM-driven agents and experiences, maintain code quality, improve observability, and help establish the technical foundation using modern AI development tools.

Lead end-to-end development of scalable web applications using Node.js, React, MongoDB, and Google Cloud. Build analytics, identity resolution, personalization, integrations, and advanced visualizations using AI-assisted, spec-driven workflows. Develop LLM integrations, configure AI agents, maintain MCP servers, automate testing and CI/CD, and support observability. Serve as a Feature Lead by guiding architecture, technical specifications, documentation, and cross-functional communication.

Designs and builds secure, scalable distributed backend systems using Python and AWS. Responsibilities include event-driven architectures, asynchronous processing, cloud data pipelines, serverless applications, REST APIs, performance optimization, authentication, and cloud security. The role requires strong distributed systems, testing, debugging, and backend development expertise, with GenAI, LLM, RAG, and vector database experience preferred.

Build, maintain, and deploy a high-volume, fault-tolerant observability platform. Architect and develop OpenTelemetry-based systems, implement services in Go (concurrency/gRPC), work with ClickHouse/Postgres, Kafka/Redis streaming, and containerized deployments on Kubernetes/Docker. Evaluate new tools and improve platform reliability and performance.

Designs and implements Go-based control-plane software for custom AI inference hardware. Responsibilities span system management APIs, Linux services, hardware interfaces, diagnostics, observability, security, firmware updates, distributed systems, and workload management. The role requires hands-on debugging across application, operating system, firmware, and hardware boundaries, plus technical leadership, mentoring, architecture, and production ownership. Regular on-site lab work includes server racking, system bring-up, hardware troubleshooting, and documentation.