Top Remote Senior Level Jobs in Des Moines, IA

Design, build, deploy, and maintain production AI/ML systems, including models, data pipelines, training workflows, agentic systems, and RAG pipelines. Monitor and optimize reliability, scalability, performance, and costs while contributing to architecture decisions. Collaborate with product, engineering, and data teams, communicate technical tradeoffs, support junior engineers, and apply responsible AI, security, observability, and containerization practices.

Lead client accounts and integrated communications campaigns focused on advocacy and social impact. Manage client relationships, strategy, project delivery, media outreach, storytelling, events, budgets, and account teams. Develop PR and marketing content, secure media placements, mentor junior staff, and deliver insights and presentations. The role requires strong communication, organization, creativity, leadership, and the ability to work autonomously in a fully remote environment.

Leads cross-functional strategic, transformation, integration, operational improvement, and client-focused projects across the biopharmaceutical and CMO/CDMO environment. Responsibilities include project planning, timeline and budget management, risk mitigation, resource alignment, stakeholder coordination, governance, executive reporting, and continuous improvement. The role supports initiatives such as mergers and acquisitions, client onboarding, strategic partnerships, and organizational change while ensuring projects remain aligned with business objectives and client commitments.

Legal Assistant supporting a litigation defense firm with insurance defense matters, including auto, trucking, transportation, commercial litigation, premises liability, and bodily injury cases. Responsibilities require strong organization, multitasking, communication, knowledge of Microsoft Office Suite and state and federal court rules. Prior trial experience is preferred.

Own strategic enterprise security engagements as the CTO Office representative, solving complex deployment and customer issues, influencing the product roadmap, building technical infrastructure and tooling, and producing technical content. The role requires deep security operations expertise, cloud architecture knowledge, hands-on coding, AI-assisted development, enterprise customer engagement experience, and frequent travel between US customers, industry events, and Tel Aviv.

Supports cash accounting processes, including daily balancing of customer payment activity, disbursements, month-end close, journal entries, and reconciliations. The role researches reconciling items, documents root causes, monitors aged items, supports governance initiatives, prepares job aids, handles reporting requests, and implements process improvements. Strong accounting, analytical, communication, organizational, and follow-up skills are required, with experience in GL or balance-sheet reconciliation preferred.

Leads strategy, roadmap, prioritization, technical scope, launch planning, and performance optimization for an AI-native mobile communication application. Partners with engineering, design, and business stakeholders on architecture, scalability, reliability, user experience, and measurable product outcomes. Requires deep technical fluency and experience launching and scaling complex technology products.

Own the strategy, roadmap, and execution for CrossFit’s Education products, including learner experiences, course registration, content delivery, learning platforms, and credentialing. Partner with Engineering, Design, Marketing, Operations, and Education leadership to prioritize investments, navigate legacy systems, improve measurement, run growth experiments, and deliver measurable learner and business outcomes.

Lead computational platform development for biological design, optimization, and functional prediction. Collaborate with wet-lab scientists to validate predictions, oversee data infrastructure and computational workflows, and contribute to technology roadmaps, funding proposals, and partnerships. The role requires developing machine learning methods for biological sequence and structure analysis, translating biological problems into computational solutions, and leading technical teams across computational and experimental disciplines.

Manages digital marketing operations across email, SMS, social media, and creative workflows. Builds and monitors Braze and Twilio campaigns, oversees vendors, maintains data quality, schedules social content, coordinates creative approvals, reports performance, and supports digital campaigns. The role also improves processes through AI automation, testing, segmentation, and data-driven optimization while collaborating across Brand, Creative, Analytics, and Performance Marketing teams.