Top Remote Senior Level Jobs in Charleston, SC

Develop and customize Salesforce solutions using Apex, Visualforce, Lightning Web Components, SOQL, and SOSL. Integrate Salesforce with external systems through REST and SOAP APIs, OAuth, and established integration patterns. Apply Salesforce architecture, security, and governor-limit expertise while using CI/CD tools such as Git, Jenkins, and Salesforce DX. Work within Agile/Scrum methodologies and translate business requirements into scalable technical solutions.

Design, build, and maintain high-quality iOS apps. Collaborate with PMs and designers, mentor engineers, and manage code ownership.

Design, build, and maintain high-quality Android app features within cross-functional squads. Collaborate with PMs, designers, backend, firmware, and QA. Improve Android codebase, contribute to architecture, code reviews, testing, and mentor engineers while owning projects end-to-end from design to release and maintenance.

Own the architecture, roadmap, and operation of Clarium’s AWS-based data platform. Build reliable batch and near-real-time pipelines, model healthcare supply chain data, optimize Postgres and Snowflake performance, and establish standards for testing, deployment, quality, and governance. Partner cross-functionally to create durable data models, lead multi-quarter initiatives, manage sensitive data controls, and mentor engineers.

Leads medium-to-large healthcare IT implementations for radiology and cardiology imaging solutions. Manages project scope, schedules, budgets, resources, documentation, risks, escalations, and customer communications. Coordinates Professional Services teams, serves as a trusted advisor to healthcare clients, mentors junior project managers, and supports PMO transformation and standardization initiatives. The role manages multiple concurrent projects and requires up to 25% travel across North America.

Owns Twist Bioscience’s brand voice, content strategy, evergreen and funnel content, and integrated 360 campaigns. Partners with marketing, brand, product, design, sales, and PR to create scientifically accurate, commercially effective content across channels. Builds messaging frameworks, style guides, briefs, and review processes while maintaining editorial quality. Requires 10+ years of agency and in-house experience, including life sciences, biotech, pharma, or related technical industries.

Designs, operates, and improves scalable cloud and on-premise infrastructure, CI/CD pipelines, Kubernetes platforms, data streaming systems, and observability tooling. Owns AWS reliability, security, cost efficiency, automation, progressive deployments, incident response, and production troubleshooting. Partners with software engineering teams to integrate services and drive continuous improvements in system performance, scalability, and uptime.

Lead treasury, token, and capital strategy across fiat, stablecoins, and $VANA. Manage liquidity and market maker relationships, design hedging and yield programs, oversee accounting, compliance, audits, and financial reporting. Advise on tokenomics, build financial models and scenario analyses, support fundraising, and negotiate liquidity and investment deals to preserve runway and advance network stability.

Design and optimize the builder funnel to attract, onboard, engage, and retain developers and founders. Run programs (hackathons, cohorts), create onboarding resources, analyze KPIs to improve conversion and retention, and build partnerships to expand the ecosystem for decentralized AI and blockchain innovation.

Build and scale reliable software systems supporting donor platforms, cash payments, and rapid-response programs. Own features end to end from architecture through deployment and monitoring, improve CI/CD and testing, troubleshoot production issues, and collaborate with product, operations, and data teams. The role also contributes to technical roadmaps and sustainable engineering practices in a mission-driven, fully remote organization.

Leads decision intelligence and agentic AI engineering across Humana’s NBA platform. Models business decisions, designs decision services and optimization strategies, and builds production AI workflows using LLMs, retrieval, tool calling, and orchestration frameworks. Oversees microservices, databases, policy engines, testing, observability, governance, and compliance. Partners with data science and business teams to operationalize reinforcement learning and improve member engagement. Leads and mentors a small engineering team while remaining hands-on.

Develop and operate reinforcement learning systems powering Humana’s Next Best Action platform. Responsibilities include RL algorithm development, reward and constraint design, simulation and backtesting, distributed Databricks and Ray RLlib training, PySpark feature engineering, MLflow model governance, production deployment, safety evaluation, and integration with rules engines and feedback pipelines. The role also requires explainability, auditability, and collaboration with healthcare, data, platform, and compliance teams.

Leads the strategy, operations, analytics, enablement, reporting, and continuous improvement of sales support functions. Partners with sales, marketing, product, operations, compliance, legal, and technology teams to improve sales effectiveness and customer outcomes. Oversees tools, workflows, dashboards, forecasting, data quality, training, change management, and cross-functional initiatives while building and developing a high-performing team.

Executes systems engineering across R&D platforms, hybrid cloud, SaaS, HPC, containers, integrations, data pipelines, observability, and AI architectures. Coordinates Enterprise IT, vendors, cybersecurity, compliance, and scientific stakeholders to deliver secure, scalable, validated, and supportable solutions. Develops technical documentation, deployment plans, runbooks, monitoring, lifecycle artifacts, risk logs, and operational handoffs. Implements RAG, vector database, AI gateway, agentic workflow, and multimodal integration patterns while supporting cloud migration, change management, governance, and technical issue resolution.