Passionate about precision medicine and advancing the healthcare industry?
Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.
We are looking for a Variant Scientist who will work with our Clinical Teams on patient molecular reports for clinical utility.
Please note: The Variant Science team works either Tuesday-Saturday or Sunday-Thursday.
Responsibilities Include:
Accurately classify somatic and germline variants for liquid biopsy, panel tests, and whole exome NGS sequencing
Utilize a variety of in-house software tools to analyze clinical molecular data
Read and interpret scientific literature and curate relevant findings in a clear, concise, and precise manner
Summarize somatic and inherited genetic test results to generate high quality clinical reports
Perform critical quality control functions for molecular reports that complies with quality management programs and standard operating procedures
Support improvements for current assays and processes
Curate variants, genes, and diseases for scientific and clinical relevance
May train junior team members
Preferred Qualifications:
MS or PhD degree in Cancer Genetics, Human Genetics, or Biological Sciences
Prior experience in a diagnostic laboratory, clinical report writing, and familiarity with human mutation databases, genome browsers, and HGVS nomenclature is preferred. Oncology experience strongly preferred
Must have utmost attention to detail, excellent communication, and writing skills
Ability to accurately follow formal documentation and protocols
Ability to work in both an individual and group setting. Must be flexible and able to adjust priorities according to workload or management needs.
Illinois Pay Range: $85,000-100,000
CA/NY Pay Range: $85,000-100,000
The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.
We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Skills Required
- Accurately classify somatic and germline variants for liquid biopsy, panel tests, and whole exome NGS sequencing
- Utilize in-house software tools to analyze clinical molecular data
- Read and interpret scientific literature and curate relevant findings
- Summarize somatic and inherited genetic test results to generate high quality clinical reports
- Perform critical quality control functions for molecular reports in compliance with quality management programs and SOPs
- Support improvements for current assays and processes
- Curate variants, genes, and diseases for scientific and clinical relevance
- May train junior team members
- MS or PhD in Cancer Genetics, Human Genetics, or Biological Sciences
- Prior experience in a diagnostic laboratory and clinical report writing
- Familiarity with human mutation databases, genome browsers, and HGVS nomenclature
- Oncology experience
- Utmost attention to detail and excellent communication and writing skills
- Ability to accurately follow formal documentation and protocols
- Ability to work independently and in a group, flexible and able to adjust priorities
- Willingness to work team schedule (Tuesday-Saturday or Sunday-Thursday)
What the Team is Saying
Tempus AI Compensation & Benefits Highlights
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Healthcare Strength — The package includes medical, dental, vision, life and disability coverage, FSA/HSA options, mental health/EAP, and pet insurance. Wellness programs, gym discounts, and commuter benefits complement the core coverage.
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Parental & Family Support — Paid parental leave and an onsite mother’s room are explicitly highlighted, alongside family medical leave. These offerings extend support for new parents beyond standard medical benefits.
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Wellbeing & Lifestyle Benefits — On‑site cafeteria meals, stocked snacks, and an on‑site barista in some offices enhance daily convenience. Hybrid/remote options and flexible schedules add meaningful lifestyle flexibility.
Tempus AI Insights
What We Do
We bring together one of the world’s largest libraries of multimodal clinical and molecular data with a robust suite of AI tools to help physicians personalize care in real time, connect patients with therapies and clinical trials, and enable partners to accelerate discovery and development of new treatments. With ~8 million de-identified research records and 350+ petabytes of data, Tempus partners with more than half of U.S. oncologists and the majority of the top 20 global pharma companies. Our teams are pioneering work across oncology, neurology, psychiatry, cardiology, and beyond—transforming how care is delivered and therapies are developed. At Tempus, every role contributes to our mission: to help each patient benefit from the experiences of those who came before. For more information, visit tempus.com.
Why Work With Us
We’re looking for people who can change the world. People who question the status quo and refuse to shy away from tough problems. For builders who are never done building, and the learners who are never done learning. Passionate individuals with undying curiosity who want to take on one of the greatest challenges humanity has ever faced—head on.
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Tempus AI Offices
Hybrid Workspace
Employees engage in a combination of remote and on-site work.
Most of the team follows a hybrid policy, with some roles allowing for a fully remote arrangement and some roles being onsite only.
