Temporary Research Associate/Senior Research Associate - IHC

Posted Yesterday
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San Jose, CA, USA
In-Office
Senior level
Biotech • Pharmaceutical
The Role
Performs histology workflows involving FFPE and fresh-frozen tissue processing, sectioning, embedding, and preparation for staining and analysis. Maintains experimental records, laboratory equipment, supplies, and safety procedures; troubleshoots technical issues and adapts workflows to changing research needs. Collaborates with scientists in a fast-paced biotechnology laboratory supporting oncology research.
Summary Generated by Built In

About Oxford BioTherapeutics:

Oxford Biotherapeutics is a clinical-stage biotechnology company focusing on the development of antibody therapeutics for the treatment of cancer. OBT’s OGAP-verify® platform is the world's largest, cancer specific, membrane protein library, directly measuring plasma membrane protein expression in patient tumors. OGAP is used to identify novel, highly tumor specific antigens for novel first-in-class ADC, T-cell Engager (TCE) and Chimeric Antigen Receptor (CAR-T) targets.  Our lead asset, OBT076, is an Antibody Drug Conjugate (ADC) in Phase 1b clinical development.  Our clinical and pre-clinical pipeline of novel biologics is balanced between internal programs, focused on ADCs and checkpoint regulators, and externally partnered programs with key innovators in oncology such as Roche, GSK and BMS. 

Purpose of the Role

We are seeking a highly motivated and adaptable Research Associate/Senior Research Associate to support a fast-paced histology laboratory in a temporary role expected to last approximately 3-4 months. The ideal candidate will have hands-on histology lab experience, strong technical skills in tissue processing and sectioning, and the ability to adapt to changing priorities and experimental needs.


Essential Duties and Responsibilities

  • Perform routine histology workflows, including processing and sectioning of FFPE and fresh-frozen (FF) tissues.
  • Prepare high-quality tissue sections for downstream staining and analysis.
  • Support day-to-day histology laboratory operations and ensure timely completion of experiments.
  • Maintain accurate experimental records and follow established laboratory procedures and safety guidelines.
  • Troubleshoot technical challenges and adapt workflows as project needs change.
  • Collaborative with scientists and other laboratory team members to support research objectives.
  • Maintain laboratory equipment, supplies, and an organized working environment.

Please note the roles and responsibilities for the position include but are not limited to the above.


Qualifications

Required

  • Bachelor’s degree from an accredited college or university in Biology, Biomedical Sciences, Histology, Medical Laboratory Science, or a related field.
  • Strong interest in working with lab tissues, preparing histology specimens, and performing standard histology laboratory procedures.
  • Strong attention to detail and ability to follow SOPs and laboratory safety requirements.
  • Ability to work independently and collaboratively in a fast-paced laboratory environment.
  • Strong verbal and written communication skills, with the ability to communicate clearly, professionally, and effectively with colleagues and stakeholders.

Preferred

  • Master’s degree or additional education in a relevant scientific discipline.
  • Histotechnology certification or specialized laboratory training.
  • Hands-on experience in a histology laboratory strongly preferred.
  • Demonstrated ability to cut FFPE and fresh-frozen (FF) tissue strongly preferred.
  • Experience with microtomy, cryostat sectioning, tissue processing, embedding, and staining.
  • Experience with IHC, IF, or other tissue-based assays.
  • Experience with automated slide scanners and automated staining platforms (in particular, the Leica Bond Rx).
  • Experience in an academic, clinical, biotechnology, pharmaceutical, or biomedical research laboratory.
  • Strong interpersonal and problem-solving skills, with the ability to collaborate effectively, ask thoughtful questions, and approach challenges with a solutions-oriented mindset.

Equal Opportunities Statement

OBT is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, and veteran status. All qualified applicants will receive consideration for employment. One of our top priorities is to maintain the health and wellbeing of our employees and their families. To achieve this goal, we offer comprehensive benefits

Skills Required

  • Bachelor's degree from an accredited college or university in Biology, Biomedical Sciences, Histology, Medical Laboratory Science, or a related field
  • Strong interest in working with laboratory tissues, preparing histology specimens, and performing standard histology laboratory procedures
  • Strong attention to detail and ability to follow SOPs and laboratory safety requirements
  • Ability to work independently and collaboratively in a fast-paced laboratory environment
  • Strong verbal and written communication skills
  • Master's degree or additional education in a relevant scientific discipline
  • Histotechnology certification or specialized laboratory training
  • Hands-on experience in a histology laboratory
  • Demonstrated ability to cut FFPE and fresh-frozen tissue
  • Experience with microtomy, cryostat sectioning, tissue processing, embedding, and staining
  • Experience with IHC, IF, or other tissue-based assays
  • Experience with automated slide scanners and automated staining platforms, particularly Leica Bond Rx
  • Experience in an academic, clinical, biotechnology, pharmaceutical, or biomedical research laboratory
  • Strong interpersonal and problem-solving skills, including effective collaboration and a solutions-oriented approach
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The Company
HQ: Oxford
55 Employees
Year Founded: 2004

What We Do

Oxford BioTherapeutics (OBT) is a clinical stage oncology company based in Oxford, UK; San Jose, CA and Morristown, NJ, USA, with a pipeline of first-in-class immuno-oncology (IO) and antibody-drug conjugate (ADC) based therapies designed to fulfil major unmet patient needs in cancer therapeutics. Our lead asset, OBT076, is an Antibody Drug Conjugate (ADC) in Phase 1b clinical development. OBT076's dual mechanism of action allows it to act as a 'primer' to re-engage the patient's immune system while at the same time targeting cancer cells directly. OBT’s proprietary OGAP® target discovery platform is based on one of the world’s largest proprietary cancer membrane proteomic databases, with data on over 5,000 cancer cell proteins providing unique, highly qualified oncology targets, of which three programs are in clinical development in the USA and Europe. The company’s pipeline and development capabilities have been validated through multiple strategic partnerships, including with Boehringer Ingelheim, ImmunoGen and Kite Pharma as well as other world leaders in antibody development (such as Amgen, WuXi, Medarex (BMS), Alere (Abbott)).

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