The Supply Chain Planning Manager is responsible for managing complex planning activities and driving operational excellence across material flow end-to-end. This role operates with a high degree of independence, providing expertise, resolving significant planning and supply chain challenges, and contributing to strategic initiatives. The incumbent partners closely with cross-functional teams, and plays a key role in improving efficiency, reducing costs, and ensuring material continuity.
This role is based at our Durham, North Carolina, office and offers a flexible working arrangement. It offers a flexible work arrangement, with the ability to work from GRAIL's office or from home. Our current flexible work arrangement policy requires that a minimum of 60%, or 24 hours, of your total work week be on-site. Your specific schedule, determined in collaboration with your manager, will align with team and business needs and could exceed the 60% requirement for the site.
Responsibilities:
- Conduct advanced demand and inventory analysis to develop replenishment strategies, optimize working capital, and reduce risk of supply disruptions.
- Responsible for a specific set of inventory items from end-to-end (planning, acquisition (through procurement), inventory receipt (through warehouse), material transfer approvals (as required), work orders (per the direction of leadership), etc.
- Expected to understand and analyze demand forecasts, historical usage, and system variances, identifying risks, and developing recommendations that support optimal material availability.
- Strong expertise in Bill of Materials ( BOM ) management in MRP software platforms, maintaining records for vertically integrated material relationships
- Develop and deliver supply chain performance reports and dashboards, providing insights and recommendations to management for strategic decision-making.
- Lead project based work throughout the year (e.g., S&OP process owner, safety stock process owner, ERP process owner).
- Act as a subject matter expert on planning and supply chain processes and systems, advising internal stakeholders on best practices and solutions.
- Lead resolution of significant material issues, escalating when necessary and ensuring minimal business disruption.
- Partner with cross-functional teams on process optimization, supply chain automation initiatives, cost savings, and operational improvements.
- As applicable, mentor and provide guidance to junior specialists and coordinators, sharing knowledge and expertise to build team capability.
- Ensure compliance with company policies, industry standards, and applicable regulatory requirements.
- Taking on additional responsibilities.
- Participating in cross functional projects and initiatives.
- Adapting to new technologies, processes, or methodologies.
- Supporting other departments or teams during periods of high demand.
- Contributing to special projects or temporary assignments as needed.
Adaptability and Growth Expectation
As our organization continues to evolve and grow, this role may require flexibility in responsibilities and duties. Employees should expect that their role may expand, shift, or be modified to meet changing business needs, strategic priorities, and organizational objectives.
This may include:
These job duties are a summary of the primary duties and responsibilities of the job and position. It is not intended to be a comprehensive or all-inclusive listing of duties and responsibilities. Contents are subject to change at the company's discretion.
Required Qualifications:
- Bachelor’s degree in Supply Chain Management, Business Administration, Operations Management, or a related field; OR a Master’s degree in a related field.
- 6 + years of relevant work experience in supply chain, procurement, logistics, or related function; OR a Master’s degree with 3+ years of relevant experience; OR a PhD in a related field with 2+ years of relevant experience.
- Advanced proficiency in ERP and supply chain management systems, with strong knowledge of reporting and analytics tools.
- Demonstrated level of knowledge regarding applicable regulatory standards commensurate with the position's complexity and scope, contributing to organizational regulatory compliance.
- Occasional travel may be required for supplier meetings, site visits, or project execution.
Preferred Qualifications :
- 8+ years of relevant work experience in supply chain, procurement, logistics, or related function; OR a Master’s degree with 5+ years of relevant experience; OR a PhD in a related field with 2+ years of relevant experience.
- Minimal applicable standards for this position include:
- GMP quality management systems (e.g. ISO 13485)
- Clinical laboratory regulations (e.g. CAP, CLIA, NYSDOH, ISO 15189)
- Operations within the regulated medical device environment (e.g. IVDD, IVDR, FDA 21 CFR 800 series, FDA 21 CFR Part 11)
- Advanced background in MRP and Excel based material modeling solutions, including the use of scripting languages to create customized solutions.
- Strong analytical and problem-solving skills to address complex planning challenges.
- Proven ability to lead cross-functional initiatives and drive measurable process improvements.
- Advanced organizational and prioritization skills to manage competing priorities in a dynamic environment.
- Leadership ability to mentor junior staff and act as a resource for the broader team.
- High attention to detail; organized with the ability to keep track of many different activities at one time.
- Have excellent communication skills, both written and verbal. A strong ability to influence internal stakeholders.
- Thrive in a dynamic environment.
- Team player and a collaborative peer.
Physical Demands & Working Environment:
- Standard office environment with frequent use of ERP systems, data analysis platforms, and reporting tools.
- Periodic work in warehouses, distribution centers, and operational areas to oversee logistics and inventory processes.
- Regular external interaction with suppliers.
- Occasional travel may be required for supplier meetings, site visits, or project execution.
- Hours and days may vary depending on operational needs.
- Standing or sitting for long periods of time may be necessary.
- May be exposed to hazardous materials, blood specimens and instruments with moving parts, heating or freezing elements, and high speed centrifugation.
- Some lifting (up to 25 pounds) may be necessary.
Skills Required
- Bachelor's degree in Supply Chain Management, Business Administration, Operations Management, or a related field
- 8-12 years of relevant work experience in supply chain, procurement, logistics, or related function
- Advanced proficiency in ERP and supply chain management systems
- Knowledge of GMP quality management systems and clinical laboratory regulations
GRAIL Compensation & Benefits Highlights
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Healthcare Strength — Health coverage is described as complete across medical, dental, and vision with multiple plan options and added mental‑health and disability support. Additional provisions such as abortion travel benefits reinforce the depth of the healthcare offering.
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Equity Value & Accessibility — Equity is positioned as a meaningful part of total rewards via new‑hire grants, inducement awards, and a discounted ESPP. Compensation materials also highlight equity alongside bonuses and structured market benchmarking.
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Leave & Time Off Breadth — Policies emphasize flexible time off, paid holidays, and company breaks, with a defined parental‑leave program. International entitlements are specifically called out, indicating breadth across regions.
GRAIL Insights
What We Do
GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is using the power of high-intensity sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop and commercialize pioneering products.
Why Work With Us
Everything we do is guided by our mission to detect cancer early, when it can be cured. It’s the reason we’re here, and it’s no small task. The right people make all the difference. That’s why we’re looking for those who strive to share their knowledge, contribute their skills, inspire each other and commit to something bigger than themselves.
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GRAIL Offices
Hybrid Workspace
Employees engage in a combination of remote and on-site work.
GRAIL has a variety of work types depending on the roles. Some roles are onsite like a lab role, some are fully remote like our Galleri Sales Consultant roles. Others are hybrid with 2-3 days onsite. Typically Tuesday and Thursday.












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