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GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured.
The Role
Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.
We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.
GRAIL is headquartered in Menlo Park, California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.
For more information, please visit grail.com.
The Staff Program Manager will provide senior-level program management expertise within GRAIL’s Global Development and Operations (GDO) Program Management team. This role is responsible for leading complex, cross-functional programs that span Development (Assay Development, Automation, and Systems & Platform Development), working in close collaboration with Research, Quality, Regulatory, Compliance, Software, and Operations functions.
This position plays a critical role in enabling seamless handoffs and transitions from Research to Development and Development to Operations for both New Product Development (NPD) and Continuous Improvement and Expansion initiatives. The ideal candidate will demonstrate strategic leadership, operational excellence, and technical acumen to drive high-impact outcomes across the full development portfolio.
This is a hybrid role in Menlo Park, CA with 3 days in office. We will also consider candidates in Durham NC.
Responsibilities
- Lead the planning, execution, and governance of large-scale programs with moderate to high complexity and strategic importance.
- Partner with cross-functional teams to ensure integrated program plans are aligned with corporate objectives and product lifecycle goals.
- Monitor and control project scope, timelines, risks, and interdependencies to ensure successful delivery of key milestones and deliverables.
- Facilitate communication and alignment across Development, Research, and Operations to optimize cross-functional collaboration and decision-making.
- Apply expert-level knowledge of project management principles, design controls, and regulatory frameworks to ensure compliant execution of product development activities.
- Act as a GDO Program Management subject matter expert (SME) by contributing to best practices, process improvements, and tool development within the organization.
- Oversee and manage program-level schedules, budgets, resource plans, and performance metrics.
- Prepare and deliver program updates, risk assessments, and mitigation plans to stakeholders and executive leadership.
- Support cross-functional investigations and process improvements aimed at enhancing operational readiness and execution quality.
- Collaborate with quality and regulatory partners to ensure alignment with internal standards and external regulatory expectations.
- Contribute to long-range strategic planning for the Development portfolio, including budgeting and capacity forecasting.
Preferred Qualifications
- Bachelor’s degree in a scientific, engineering, or technical discipline and 8–12 years of relevant experience; or Master’s degree with 5–8 years; or PhD with 2–5 years in the diagnostics, medical device, pharmaceutical, or biotech industry.
- 2+ years of direct program or project management experience in regulated product development or clinical laboratory operations.
- Demonstrated experience working under design control and executing design transfer processes.
- Familiarity with managing post-approval regulatory changes and associated cross-functional impacts.
- PMP Certification is highly desirable.
- Ability to travel 10-20%.
- Strategic thinker with strong analytical and problem-solving capabilities.
- Proficient in program management tools and methodologies (e.g., MS Project, Smartsheet, JIRA, Workday Project, or equivalent).
- Effective communicator with the ability to engage and influence stakeholders at all organizational levels.
- Demonstrated ability to operate independently, exercise sound judgment, and drive initiatives to completion.
- Proven track record in navigating complex, matrixed environments and leading cross-functional teams.
Key Competencies:
Expected full time annual base pay scale for this position is $163K-$204K. Actual base pay will consider skills, experience and location.
Based on the role, colleagues may be eligible to participate in an annual bonus plan tied to company and individual performance, or an incentive plan. We also offer a long-term incentive plan to align company and colleague success over time.
In addition, GRAIL offers a progressive benefit package, including flexible time-off, a 401k with a company match, and alongside our medical, dental, vision plans, carefully selected mindfulness offerings.
GRAIL is an Equal Employment Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status. We will reasonably accommodate all individuals with disabilities so that they can participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. GRAIL maintains a drug-free workplace.
What the Team is Saying
Neda Ronaghi
Strategy and Operational Excellence Associate Director
Ruth Mauntz
Staff Bioinformatics Scientist
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Tristan Matthews
Senior Director, Software Engineering
David Jenions
Principal Automation Engineer
Satnam Alag
SVP, Software Engineering
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GRAIL Compensation & Benefits Highlights
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Healthcare Strength — Health coverage is described as complete across medical, dental, and vision with multiple plan options and added mental‑health and disability support. Additional provisions such as abortion travel benefits reinforce the depth of the healthcare offering.
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Equity Value & Accessibility — Equity is positioned as a meaningful part of total rewards via new‑hire grants, inducement awards, and a discounted ESPP. Compensation materials also highlight equity alongside bonuses and structured market benchmarking.
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Leave & Time Off Breadth — Policies emphasize flexible time off, paid holidays, and company breaks, with a defined parental‑leave program. International entitlements are specifically called out, indicating breadth across regions.
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The Company
What We Do
GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is using the power of high-intensity sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop and commercialize pioneering products.
Why Work With Us
Everything we do is guided by our mission to detect cancer early, when it can be cured. It’s the reason we’re here, and it’s no small task. The right people make all the difference. That’s why we’re looking for those who strive to share their knowledge, contribute their skills, inspire each other and commit to something bigger than themselves.
Gallery
GRAIL Offices
Hybrid Workspace
Employees engage in a combination of remote and on-site work.
GRAIL has a variety of work types depending on the roles. Some roles are onsite like a lab role, some are fully remote like our Galleri Sales Consultant roles. Others are hybrid with 2-3 days onsite. Typically Tuesday and Thursday.
Typical time on-site:
2 days a week
