Passionate about precision medicine and advancing the healthcare industry?
Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.
As a Sr Manager, you will be the primary guardian of data reliability and a mentor to a high-performing engineering squad. You are a "Data Reliability Engineer" who ensures that our complex multi-modal datasets—spanning clinical records, genomics and radiology —are accurate, traceable, and ready for high-stakes applications like machine learning and clinical decision-making.In this leadership capacity, you will manage a small team of engineers leveraging cutting-edge AI-assisted development tools to accelerate delivery.
What You’ll DoTeam Leadership & Mentorship: Lead and manage a small, agile team of software engineers. Conduct code reviews, provide technical guidance, and foster a culture of excellence in data quality and engineering best practices.
DBT Testing & Quality Gates: Architect and implement a comprehensive testing suite within DBT. Design and enforce data quality gates in the CI/CD and ETL pipeline to ensure that only high-integrity data reaches production environments.
Deep Data Analysis & Profiling: Perform exhaustive data profiling and deep-dive analyses using SQL and Python to evaluate completeness, identify hidden patterns, and resolve structural inconsistencies.
Product Strategy & Planning: Collaborate directly with Product Managers and other Team Leads to develop and prioritize the product backlog. You will be responsible for identifying work estimates and refining complex requirements into actionable technical tasks.
Modern Data Stack & Observability: Architect and implement robust observability frameworks using BigQuery, DBT, Elementary, and Grafana to create real-time monitors, alerts, and dashboards that track the health and lineage of our data ecosystem.
AI-Driven Development: Champion the use of AI productivity tools—such as Cursor, Claude, and GitHub Copilot—to streamline development, automate testing, and refactor legacy data pipelines efficiently.
Statistical Insights & KPIs: Define and report on key Data Quality KPIs (e.g., freshness, volume, and schema changes) using correlation and trend analysis to provide platform-wide transparency.
Advanced Data Modeling: Manage an enterprise data model integrating multiple domains (Clinical, NGS, Radiology) across relational and NoSQL technologies.
Technical Proficiency: You are an expert in the modern data engineering stack, specifically DBT, SQL, and Python.
Leadership Experience: You have a proven track record of leading or mentoring a small team of engineers in a fast-paced environment.
Observability & AI Savvy: You have hands-on experience with observability tools (e.g., Elementary, Grafana) and are proficient in leveraging AI coding assistants (Cursor, Claude, Copilot) to enhance team velocity.
Domain Expertise: You have a strong background in healthcare and next-generation sequencing (NGS) data.
Analytical Powerhouse: You use data profiling and correlation analysis to solve complex data integrity problems.
Communication: Ability to translate technical data quality gaps into actionable insights for both internal developers and external stakeholders.
Chicago: $150,000 - $210,000
NY/SF: $175,000 - $225,000
The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.
We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Skills Required
- Expert in the modern data engineering stack
- Proven leadership experience managing engineering teams
- Strong background in healthcare and next-gen sequencing data
- Hands-on experience with observability tools and AI coding assistants
- Ability to perform deep data analysis and profiling
What the Team is Saying
Tempus AI Compensation & Benefits Highlights
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Healthcare Strength — Healthcare coverage spans medical, dental, vision, life/AD&D, short‑term disability, mental‑health/EAP, FSAs, and even pet insurance. Feedback suggests this breadth meets core needs for many employees.
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Wellbeing & Lifestyle Benefits — On‑site cafeteria meals, stocked snacks, an on‑site barista, commuter benefits, gym discounts, ERGs, and regular events enhance daily experience, especially at Chicago HQ. Feedback suggests these amenities add tangible value for those working regularly on‑site.
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Parental & Family Support — Parental leave and an onsite Mother’s Room are highlighted, alongside hybrid work in many roles. Feedback suggests these supports help work‑life integration for caregivers.
Tempus AI Insights
What We Do
We bring together one of the world’s largest libraries of multimodal clinical and molecular data with a robust suite of AI tools to help physicians personalize care in real time, connect patients with therapies and clinical trials, and enable partners to accelerate discovery and development of new treatments. With ~8 million de-identified research records and 350+ petabytes of data, Tempus partners with more than half of U.S. oncologists and the majority of the top 20 global pharma companies. Our teams are pioneering work across oncology, neurology, psychiatry, cardiology, and beyond—transforming how care is delivered and therapies are developed. At Tempus, every role contributes to our mission: to help each patient benefit from the experiences of those who came before. For more information, visit tempus.com.
Why Work With Us
We’re looking for people who can change the world. People who question the status quo and refuse to shy away from tough problems. For builders who are never done building, and the learners who are never done learning. Passionate individuals with undying curiosity who want to take on one of the greatest challenges humanity has ever faced—head on.
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Tempus AI Offices
Hybrid Workspace
Employees engage in a combination of remote and on-site work.
Most of the team follows a hybrid policy, with some roles allowing for a fully remote arrangement and some roles being onsite only.
