Sr Automation Engineer

Posted Yesterday
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South San Francisco, CA, USA
In-Office
140K-169K Annually
Senior level
Biotech
The Role
Develop, validate, and maintain automated liquid-handling methods for high-throughput synthetic biology and genomics workflows. Support Hamilton STAR liquid handlers, dispensers, analytical instruments, sequencers, robotics, and integrated systems. Lead validation projects, documentation, production-system maintenance, LIMS integrations, and workflow optimization while meeting ISO 13485 standards. Collaborate with Operations, R&D, Quality, and equipment manufacturers to implement robust laboratory automation solutions.
Summary Generated by Built In
Sr Automation Engineer (Onsite in South San Francisco, CA)Summary

We are looking for a talented laboratory automation engineer to join the Automation team. In this role, you will deploy automated solutions to the back-end of Twist operations, where synthesized DNA is converted into finalized products. With a specialization in the Hamilton STAR, you will develop, validate, and maintain automated liquid handling methods. Beyond providing hands-on support to Twist’s diverse fleet of liquid handlers, you  will also work with bulk dispensers, analytical instrumentation, integrated automation systems, and custom robotics. Reporting within the Engineering organization, you will collaborate closely with Operations, R&D, and Quality to release robust, automated workflows in a fast-paced environment.

What You’ll Be Doing
  • Develop, validate, and maintain automated liquid handling methods supporting high-throughput workflows across Twist's synthetic biology and genomics product lines
  • Provide hands-on support for liquid handlers, bulk dispensers, analytical instrumentation, sequencers, and integrated automation systems
  • Lead validation projects, author technical documentation, and maintain existing production systems.
  • Collaborate within cross-functional teams to optimize existing processes, gather requirements for new processes, and integrate hardware with Twist LIMS
  • Evaluate instrument manufacturers' native software and automation offerings, communicate integration needs, and build in-house solutions when needed
  • Ensure work complies with regulatory and ISO 13485 quality standards 
What You’ll Bring to the Team
  • B.S. or M.S. in Engineering, Life Sciences, or a related field with 7+ years of relevant industry experience in laboratory automation
  • 5+ years hands-on experience operating and programming robotic liquid handlers, with demonstrated expertise in Hamilton Robotics
  • Proven track record of successfully translating manual assays from bench to stand alone workstations or fully integrated platforms
  • Hands-on experience with sample tracking software, writing software requirements, and developing interfaces with LIMS
  • Strong scientific computation, data analysis, and problem-solving skills
Preferred Qualifications
  • Proficiency in scripting and programming languages (e.g., Python, C#, VBScript) for custom data handling or workflow extension.
  • Prior experience with Next-Generation Sequencing (NGS) assay automation.
  • Experience working within ISO 13485 or other quality management systems.

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.
San Francisco Bay Area Pay Range
$140,000$169,000 USD

Skills Required

  • Bachelor’s or master’s degree in Engineering, Life Sciences, or a related field
  • 7+ years of relevant industry experience in laboratory automation
  • 5+ years of hands-on experience operating and programming robotic liquid handlers
  • Demonstrated expertise with Hamilton Robotics
  • Experience translating manual assays to standalone workstations or fully integrated platforms
  • Experience with sample tracking software
  • Experience writing software requirements
  • Experience developing interfaces with LIMS
  • Strong scientific computation, data analysis, and problem-solving skills
  • Proficiency in Python, C#, or VBScript
  • Experience with next-generation sequencing assay automation
  • Experience working within ISO 13485 or another quality management system
Am I A Good Fit?
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The Company
HQ: San Francisco, CA
657 Employees
Year Founded: 2013

What We Do

Twist Bioscience is a synthetic biology company based in South San Francisco, California. The company has developed a proprietary silicon-based manufacturing process for the production of synthetic DNA. Twist Bioscience serves Life Science researchers who are changing the world for the better. Coming from diverse fields of medicine, agriculture, industrial chemicals and data storage, scientists use our synthetic genes, oligo pools, and NGS target enrichment to better lives and improve the sustainability of the planet. Twist Bioscience is uniquely positioned to help accelerate these efforts by providing precision at a scale that is otherwise unavailable. Our technology overcomes inefficiencies and enables cost-effective, rapid, precise, high-throughput DNA synthesis and sequencing. We offer both the quality and quantity researchers need now to rapidly realize opportunities ahead.

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