Mayo Clinic’s Genomics and Emerging Systems Unit is seeking a Software Engineer to design, develop, and maintain .NET-based applications and services that support genomics and clinical workflows. These systems run in on-premises and cloud environments, including Microsoft Azure and Google Cloud Platform (GCP), and integrate with other enterprise systems through secure APIs and web services. The Software Engineer will build and optimize services that handle complex laboratory workflows, clinical datasets, and high-volume genomic data processing. This includes ensuring services meet performance, reliability, data integrity, and quality requirements as data volumes grow.
The role collaborates closely with cross-functional teams to translate business, clinical, and technical requirements into maintainable software solutions that meet federal regulatory guidelines. Software Engineer responsibilities include designing and implementing services aligned to enterprise architecture, including cloud-ready APIs, data integration pipelines, and secure interoperability layers for systems that primarily support genomic data and laboratory workflows.
The engineer participates in Agile and DevOps practices using tools such as GitHub, Azure DevOps, Azure Pipelines, and CI/CD frameworks. Work may include deployment automation and configuration management for both on-premises and cloud-hosted applications. Development efforts leverage modern .NET technologies, cloud-native patterns, API-first design, and secure coding practices. Responsibilities also include maintaining comprehensive technical documentation, contributing to code reviews, and participating in advanced troubleshooting through log analysis, root cause evaluation, and data/system investigation.
This position requires effective communication with peers, leaders, and clinical partners across the organization. The engineer will develop working knowledge of laboratory genomics workflows, organizational processes, and customer needs while performing technical assignments with moderate guidance and increasing autonomy.
This is a full time, limited tenure, remote position funded for 2 years. Mayo Clinic will not sponsor or transfer visas for this position including F-1 OPT STEM.
Bachelor's degree in Computer Science/Engineering or related field; Or an Associates’ degree in Computer Science/Engineering or related field with an additional 2 years of experience as described below.
- Have working knowledge and experience of Software Engineering with a minimum of internships and a minimum of 1 yr. of experience, or 2yrs of experience coding applications or services in a high-level language (C, C++, Golang, Java, C# etc.).
- Demonstrated problem solving and time management skills.
- Possesses strong technical aptitude for designing and implementing software solutions.
- Experience with modern application development frameworks
- Knowledge of professional software engineering practices & best practices for the full software development life cycle, including coding standards, code reviews, source control management, build processes, testing, and operations.
- Deep hands-on technical expertise, excellent verbal and written communication skills.
- Experience with Agile software development techniques.
Preferred qualifications:
- Experience developing applications in hybrid environments, including on-premises systems, Microsoft Azure, and Google Cloud Platform (GCP).
- Proficiency with C# .NET and Angular for developing modern application components, APIs, and web-based user experiences.
- Experience supporting or modernizing legacy Windows desktop applications, including WinForms and/or WPF applications that predate modern cloud-native tooling.· Have working knowledge and experience of Software Engineering with a minimum of internships and a minimum of 1 yr. of experience, or 2yrs of experience coding applications or services in a high-level language (C, C++, Golang, Java, C# etc.).
- Familiarity with RESTful APIs, microservices, web services, DevOps pipelines, and CI/CD using Azure DevOps, GitHub Actions, Azure Pipelines, or similar tooling.
- Experience with relational or NoSQL databases, analytics platforms, big-data processing, and/or enterprise data pipelines.
- Familiarity with AI coding tools and/or specification-driven development.
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Experience supporting or developing solutions in healthcare, clinical, Bioinformatics or genomics-focused applications is highly desirable.
This vacancy is not eligible for sponsorship/we will not sponsor or transfer visas for this position. Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.This position is Limited Tenure. Limited Tenure (LT) means that if you are offered the position and accept it:
• You will be categorized as a regular employee during this tenure, but employment will be terminated at the established end date.
• You commit to stay in this position until the end of the tenure (approximately x months from date of hire) before you become eligible to transfer to a new position.
• After the completion of the limited tenure assignment, it is your responsibility to secure another role within Mayo through the job vacancy process or employment will be ended upon the completion of the limited tenure assignment.
Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
- Medical: Multiple plan options.
- Dental: Delta Dental or reimbursement account for flexible coverage.
- Vision: Affordable plan with national network.
- Pre-Tax Savings: HSA and FSAs for eligible expenses.
- Retirement: Competitive retirement package to secure your future.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law". Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.
Skills Required
- Bachelor's degree in Computer Science, Engineering, or related field; OR Associate's degree plus 2 years relevant experience
- Minimum of internships plus at least 1 year of professional experience, or 2 years coding applications/services in a high-level language (C, C++, Golang, Java, C#)
- Experience with modern application development frameworks
- Knowledge of professional software engineering practices (coding standards, code reviews, source control, build processes, testing, operations)
- Experience with Agile software development techniques
- Demonstrated problem solving, time management, and strong verbal/written communication skills
- Deep hands-on technical expertise for designing and implementing software solutions
- Experience developing in hybrid environments (on-premises, Azure, GCP)
- Proficiency with C# .NET and Angular
- Experience with legacy Windows desktop applications (WinForms and/or WPF)
- Familiarity with RESTful APIs, microservices, DevOps pipelines, and CI/CD tooling (Azure DevOps, GitHub Actions, Azure Pipelines)
- Experience with relational or NoSQL databases, analytics platforms, big-data processing, or enterprise data pipelines
- Familiarity with AI coding tools and specification-driven development
- Experience in healthcare, clinical, bioinformatics, or genomics-focused applications
Mayo Clinic Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Mayo Clinic and has not been reviewed or approved by Mayo Clinic.
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Retirement Support — A no-cost pension plus an employer-matched 403(b)/401(k) is positioned as a standout differentiator, offering strong long-term financial security. Feedback suggests this retirement combination elevates overall total rewards even when base pay is moderate.
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Healthcare Strength — Expanded medical networks, enhanced fertility coverage, and employer absorption of a plan year’s premium increases point to robust healthcare offerings. Feedback suggests annual updates maintain breadth and competitiveness of coverage.
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Parental & Family Support — Adoption assistance, dependent scholarships, child and elder-care resources, and EAP services provide meaningful family-oriented support. Feedback suggests these programs add tangible value beyond salary alone.
Mayo Clinic Insights
What We Do
Mayo Clinic is the first and largest integrated, not-for-profit medical group practice in the world. Doctors from every medical specialty work together to care for patients, joined by common systems and a philosophy of "the needs of the patient come first." More than 3,800 physicians and scientists and 50,900 allied health staff work at Mayo Clinic, which has sites in Rochester, Minn., Jacksonville, Fla., and Scottsdale/Phoenix, Ariz. Mayo Clinic also serves over 70 communities through Mayo Clinic Health System with locations in MN, IA, and WI. Collectively, these locations care for more than 1 million people each year.
