Senior Software Engineer II, GenAI Genomics

Sorry, this job was removed at 06:06 p.m. (CST) on Wednesday, Sep 10, 2025
Chicago, IL
Hybrid
130K-190K Annually
Artificial Intelligence • Big Data • Healthtech • Machine Learning • Analytics • Biotech
Tempus is a technology company leading the adoption of AI to advance precision medicine and patient care.
The Role

Passionate about precision medicine and advancing the healthcare industry?

Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.

We are seeking a highly motivated and capable Senior Engineer to further our Genomics AI initiatives. This person should have experience and interest in leading analysis and design of technical problems, mentoring & coaching emerging talent during this transformative time in Tech. This position requires experience with programming (full stack), relational data systems and algorithms development. Top candidates will also have experience crafting code while leveraging AI tooling and embedding agentic workflows in their product.

Why we’re looking for you:

  • You've got several years of experience working on software development teams, and can support your team by leading technical analysis & design, evaluating tradeoffs, and establishing best practices

  • You are passionate about leveraging Generative AI and possess demonstrable experience embedding AI, LLM, or agentic workflows into products, and utilizing AI-based tools within your development processes

  • You love exploring hard problems and solving them in ways that scale well for the future, balancing delivery timelines, stakeholder needs, and technical realities 

  • You understand the challenges and appreciate the rewards of a distributed architecture

  • You've worked in fast-paced, agile environments and helped keep projects on track, troubleshoot roadblocks, write documentation, and coordinate cross-team collaboration

  • You enjoy learning from and collaborating with a diverse, talented team and mentoring junior team members

  • You have a track record of diving into complex domains and leveraging your understanding to provide insightful input into the product development process

Bonus points for:

  • Experience with Docker, AWS, GCP

  • Experience in React, NodeJS, MySql

  • Experience in biotech, genomics, and precision medicine

Responsibilities:

  • Actively research, evaluate, and champion the adoption of Generative AI technologies and best practices within the team and across the organization

  • Define technical solutions or efficient operational processes that level up the team

  • Autonomously define and deliver technical roadmaps of larger projects, often involving cross-team dependencies

  • Lead the design and implementation of solutions that integrate AI, LLM, and agentic workflows to enhance product capabilities and operational efficiency

  • Actively keep customer needs in mind and leverage input from product stakeholders as available to determine the right technical solution to deliver customer value quickly

  • Gain a broader understanding of the business context and team goals to enable independent technical decisions in the face of open-ended requirements

  • Set audacious goals, take risks, and share lessons learned

  • Define technical roadmaps for complex projects and provide leadership for the people executing on those projects

  • Build relationships and drive coordination across teams and disciplines, helping get to positive outcomes

  • Give quality feedback on designs written by other members of the team, asking probing and insightful questions to solidify choices and surface erroneous assumptions

  • Roll our components and major features, while deprecating existing systems or features, reliably

  • Design clear success metrics and achieve those metrics consistently post-launch through the lifetime of the system or feature

  • Mentor team members on the effective use of AI tools and methodologies, fostering a culture of innovation and continuous learning in the AI space

Join us in building software solutions that are revolutionizing healthcare and improving patient outcomes worldwide.

#LI-SH1

CHI: $130,000-$190,000

The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.

We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. 

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The Company
HQ: Chicago, IL
3,775 Employees
Year Founded: 2015

What We Do

We bring together one of the world’s largest libraries of multimodal clinical and molecular data with a robust suite of AI tools to help physicians personalize care in real time, connect patients with therapies and clinical trials, and enable partners to accelerate discovery and development of new treatments.

With ~8 million de-identified research records and 350+ petabytes of data, Tempus partners with more than half of U.S. oncologists and the majority of the top 20 global pharma companies. Our teams are pioneering work across oncology, neurology, psychiatry, cardiology, and beyond—transforming how care is delivered and therapies are developed.

At Tempus, every role contributes to our mission: to help each patient benefit from the experiences of those who came before.

For more information, visit tempus.com.

Why Work With Us

We’re looking for people who can change the world. People who question the status quo and refuse to shy away from tough problems. For builders who are never done building, and the learners who are never done learning. Passionate individuals with undying curiosity who want to take on one of the greatest challenges humanity has ever faced—head on.

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