Passionate about precision medicine and advancing the healthcare industry?
Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.
Senior Application Security Engineer
Tempus is seeking a Senior Application Security Engineer with deep expertise in penetration testing to join our Application Security team. In this role, you will lead efforts to identify and remediate vulnerabilities in our web, mobile, and medical device applications, helping to safeguard sensitive healthcare data and support our mission to improve patient outcomes.
Responsibilities:
Conduct penetration tests on web, mobile, and software medical device applications, as well as internal systems.
Lead threat modeling and risk assessment activities for new and existing products.
Develop and execute test plans, scenarios, scripts, or procedures.
Document findings, prepare detailed reports, and work with development teams to remediate identified issues.
Track and manage vulnerabilities through their lifecycle.
Develop and maintain custom security testing tools and automation scripts.
Stay up-to-date with the latest testing and ethical hacking methods, tools, and industry trends.
Assist in the development and maintenance of application security policies, standards, and guidelines.
Work with security and IT teams to enhance the overall security posture of the organization.
Provide security training and awareness to development teams.
Participate in the design and review of new technologies and major changes to existing technologies from a security perspective.
Ensure compliance with healthcare and data privacy regulations (e.g., HIPAA, GDPR).
Evaluate third-party applications and vendors for security risks.
Mentor junior team members and contribute to a culture of security.
Qualifications:
5+ years of proven experience in penetration testing, with a strong preference for experience in healthcare or other highly regulated environments.
Strong understanding of security principles, techniques, and technologies.
Experience with a variety of security tools and products (e.g., Burp Suite, Snyk, Metasploit, Nmap).
Familiarity with programming/scripting languages such as Python, JavaScript/TypeScript, or others.
Experience with cloud security (AWS, Azure, GCP) and secure SDLC practices.
Excellent problem-solving, analytical, communication, and interpersonal skills.
Relevant certifications such as OSCP, GPEN, OSCE, GWAPT, CSSLP, or similar are highly desirable.
Experience mentoring and training others in security best practices.
The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.
We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Top Skills
What We Do
We bring together one of the world’s largest libraries of multimodal clinical and molecular data with a robust suite of AI tools to help physicians personalize care in real time, connect patients with therapies and clinical trials, and enable partners to accelerate discovery and development of new treatments.
With ~8 million de-identified research records and 350+ petabytes of data, Tempus partners with more than half of U.S. oncologists and the majority of the top 20 global pharma companies. Our teams are pioneering work across oncology, neurology, psychiatry, cardiology, and beyond—transforming how care is delivered and therapies are developed.
At Tempus, every role contributes to our mission: to help each patient benefit from the experiences of those who came before.
For more information, visit tempus.com.
Why Work With Us
We’re looking for people who can change the world. People who question the status quo and refuse to shy away from tough problems. For builders who are never done building, and the learners who are never done learning. Passionate individuals with undying curiosity who want to take on one of the greatest challenges humanity has ever faced—head on.
Gallery
Tempus AI Offices
Hybrid Workspace
Employees engage in a combination of remote and on-site work.
Most of the team follows a hybrid policy, with some roles allowing for a fully remote arrangement and some roles being onsite only.






























