Company Summary
FL106 Inc. is a privately held, early-stage biotechnology company focused on developing novel drug delivery modalities. FL106 is backed by Flagship Pioneering, which provides the strategic vision and resources to advance FL106 from platform validation to clinical impact.
Position Summary
We are seeking a (senior) scientist with strong hands-on expertise in protein engineering and working knowledge of AI/ML tools. This candidate will engineer proteins and antibodies both at the bench and in silico for the design of delivery modalities. The ideal candidate thrives in a fast-paced, collaborative start-up environment and is eager to contribute directly to FL106’s scientific platform.
Responsibilities
- Design and experimentally test novel protein scaffolds, leveraging structural modeling, rational design, and/or directed evolution
- Execute hands-on protein production, purification, and functional characterization in the lab
- Stay current with computational protein design to inform design strategies and implement emerging technologies
- Collaborate with companies in the Flagship ecosystem to evaluate and integrate novel ML models relevant to FL106’s design principles
- Contribute to the strategic direction of the computational team and help shape FL106’s design platform
- Identify and lead external research collaborations with academic and commercial partners
- Report results clearly to the scientific team and Flagship Pioneering management
Key Qualifications
- Ph.D. (with 2+ years of industry experience) or Masters (10+ years of industry experience) in protein biochemistry, molecular biology, computational protein design, computational biology, or a related field
- Proven track record of drug development in the form of patents and first author publications.
- Hands-on experience in protein production, purification, and biophysical characterization — candidates without direct bench experience will not be considered
- Expertise in protein engineering, structural biology, and structural modeling/visualization
- Experience with SPR, ITC, KinExa, and related techniques
- Experience designing antibodies, nanobodies, and therapeutic proteins
- Proficiency with ML tools for computational protein design (e.g., AlphaFold, RosettaFold, ESMFold, ProteinMPNN, RFDiffusion, Chroma, IgFold, DeepAb, Parapred)
- Ability to move fluidly between technical detail and high-level strategic context
- Strong communicator and collaborative team player with keen attention to detail
About Flagship
Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in generation of over 500 patents, initiation of over 50 clinical trials for novel therapeutic agents and an aggregate value of more than $90 billion. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.
Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
The salary range for this role is $115,000 - $258,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL108 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL108's good faith estimate as of the date of publication and may be modified in the future.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact [email protected].
Skills Required
- Ph.D. with 2+ years of industry research experience in computational protein design, protein biochemistry, computational biophysics, computational biology, physics, or related field
- Expertise in computational protein modeling and design, structural biology, and biophysics
- Deep expertise with ML tools for computational protein design such as AlphaFold, RosettaFold, ESMFold, ProteinMPNN, RFDiffusion, Chroma, IgFold, DeepAb, Parapredis
- Experience with antibody and/or nanobody modeling and design
- Knowledge of wet-lab protein engineering techniques (phage display, SPR, ITC, CD-spectroscopy)
- Strategic thinker able to connect detailed science to high-level context
- Excellent communication skills, team player, strong attention to detail
What We Do
Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique, hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $30 billion in aggregate value. To date, Flagship is backed by >$3 billion of aggregate capital commitments, of which over $1.5 billion has been deployed toward the founding and growth of its pioneering companies alongside >$10 billion of follow-on investments from other institutions. The current Flagship ecosystem includes Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Seres Therapeutics (NASDAQ: MCRB), and Syros Pharmaceuticals (NASDAQ: SYRS).
