About Sail
Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.
The Role
The Senior Research Associate, Platform RNA Sciences, will work on key projects to advance Sail’s first-in-class programmable circular RNA technology (Endless RNA™ or eRNA). This role will help optimize eRNA purification processes, improve circularization, and upgrade our eRNA design. The successful candidate is organized, and attentive to details, a fast learner with a strong sense of responsibility who takes pride in his/her work. The team looks forward to helping you strive in this exciting and fast-paced environment to make a real-world impact on patients’ lives.
Responsibilities
- Perform experiments to optimize eRNA purification
- Determine circularization efficiency and impurity levels by running analytic assays
- Conduct library and small scale eRNA production for platform learning projects
- Monitor RNA immune reactivity and protein expression in cells
- Design properly controlled experiments, generate high-quality data, and run rigorous statistical analysis
- Maintain detailed documentation in electronic lab notebooks
- Present findings clearly to platform teams and contribute to scientific discussions and decision-making
Qualifications
- B.S. in Life Sciences, Chemistry, Engineering, or a related field with 4+ years or M.S. with 2+ years of full-time industry or academic research experience
- Experience using data analysis and information management tools, such as Excel, Graphic Prism, JMP, SnapGene, Benchling
- Ability to manage multiple tasks at once while knowing how to prioritize
- Strong collaborative spirit and communication skills
- Excellent record keeping
Preferred Qualifications
- Experience in RNA production and purification
- Familiarity with high-performance liquid chromatography (HPLC) or other column-based purification/analytic methods
- Experience in cell culture and assays to monitor protein expression (e.g., ELLA, ELISA, IncuCyte, flow cytometry)
Salary Range: $75,000 - $95,000
Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.
Skills Required
- B.S. in Life Sciences, Chemistry, Engineering, or a related field with 4+ years of full-time industry or academic research experience
- M.S. with 2+ years of full-time industry or academic research experience
- Experience using data analysis and information management tools such as Excel, GraphPad Prism, JMP, SnapGene, or Benchling
- Ability to manage multiple tasks and prioritize effectively
- Strong collaboration and communication skills
- Excellent record keeping
- Experience in RNA production and purification
- Familiarity with HPLC or other column-based purification and analytical methods
- Experience with cell culture and assays monitoring protein expression, such as ELLA, ELISA, IncuCyte, or flow cytometry
What We Do
Senda Biosciences, Inc. is uniquely positioned to transform human health by harnessing millions of years of evolution to program targeted, potent and tunable medicines. Nature has provided the codes to program human cells – both within the cell (mRNA), and, remarkably, to the cell - using what surrounds it. The trillions of non-human cells in the human ecosystem have evolved natural nanoparticles that precisely shuttle biomolecules into human cells, providing the missing pieces to fully unlock programmable medicines. Senda’s proprietary platform includes the first-ever atlas of nature-derived programmable systems at the molecular level and across all kingdoms of life – accessing the entire code provided by nature required to program cells. With this platform, Senda is developing a new class of SendRNA™ medicines. The unique properties of these medicines create new frontiers for mRNA therapeutics and vaccines for infectious, genetic, autoimmune, and metabolic diseases and oncology indications – with further potential to transform the gene editing and protein-based therapy landscapes as well. Based in Cambridge, MA, Senda was founded by Flagship Pioneering.
