Senior Principal Scientist, Immune Cell Depletion Discovery Group, Immunology Discovery Research
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.
Job DescriptionThe Immunology Discovery Therapeutic Area is seeking an accomplished and experienced Scientist to lead the Immune Cell Depletion Group within the Immune Reset Therapeutics Discovery team based in Cambridge MA. In this role you will lead a multidisciplinary team of highly talented scientists with experimental, technical and scientific expertise in cellular depletion approaches. The candidate should have a demonstratable track-record in this scientific discipline alongside a strong knowledge of preclinical drug discovery spanning target discovery / validation through to GLP toxicology phases. The ability to effectively collaborate and deliver results across multi-disciplinary line functions both internally and with external leading experts is required. Proven expertise leading preclinical drug discovery programs leveraging cellular depletion approaches in autoimmune disease is an advantage. Applicants should have a strong publication record and have proven experience in leading (managing) & developing bench-based scientists.
Key Responsibilities:
- Lead the Immune Cell Depletion Group within Immunology Discovery. Responsible for refining the strategy and biology focus within this area to support and advance the portfolio
- Provide biology expertise to internal teams that helps pave the way for next-generation therapies that leverage cell depletion approaches to develop next generation therapies for rheumatological, dermatological, gastroenterological and respiratory diseases
- Key member of the Immune Reset Therapeutics Discovery Leadership Team, to support advancement of Immune Tolerance biology into the drug discovery pipeline
- Proven experience in managing, growing and developing highly talented scientists
- Drive performance by Leading from the Bench. Including the ability to design and execute on key experiments to inform decision-points (GO / NO-GO) at critical stages of projects
- Proven track record of leading and influencing early to late-stage discovery programs
- Deep immunology expertise, with emphasis on understanding how cell depletion approaches can potentially raise the treatment ceiling for patients with autoimmune disease
- Help develop and execute a strategy in alignment with functional goals and key scientific objectives in discovery immunology research.
- Highly collaborative, team-oriented, and considerate of the needs of others
- Strong interpersonal skills and ability to collaborate with diverse groups within the organization and external partners.
- Highly organized & self-directed, capable of leading multiple complex research programs in parallel.
- Excellent written and verbal communication is required as well as critical evaluation and data-driven decision making.
- Provide expert advice and share knowledge with direct reports, peers, and senior leadership
- Establish and manage external collaborations with leading research labs around the world. Includes attendance / presentation at conferences and submission of publications.
- 18 +(BS), 16+ (MS), or 10+ (PhD) years of related work experience in academia, biotech or pharma
- Extensive experience in Immunology drug discovery within a high-caliber research environment with 6+ years of related work experience in biotech or pharma
- Ability to create an inclusive environment where diverse ideas, viewpoints and backgrounds are valued. Willingness and ability to lead inclusively and demonstrate a commitment to listen and consider all points of view
- Ability to work, influence, lead and deliver results in cross-functional teams
- Excellent written, presentation and interpersonal communication skills. Ability to be effective in a highly collaborative environment.
Key AbbVie Competencies:
- Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance.
- Learns fast, grasps the “essence” and can change course quickly where indicated.
- Raises the bar and is never satisfied with the status quo.
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of thisposting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location,and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our long-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission,incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless anduntil paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
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Skills Required
- 18+ years (BS), 16+ years (MS), or 10+ years (PhD) related work experience in academia, biotech, or pharma
- Extensive immunology drug discovery experience spanning target discovery/validation through GLP toxicology
- Demonstrable track record in immune cell depletion approaches and leading preclinical drug discovery programs
- Proven experience managing, growing, and developing bench-based scientists and leading multidisciplinary teams
- Strong publication record
- Ability to design and execute key experiments to inform go/no-go decisions and lead from the bench
- Excellent written, presentation, and interpersonal communication skills; effective in collaborative cross-functional environments
- Proven expertise in cell-depletion approaches for autoimmune disease (advantage)
- Experience establishing and managing external collaborations, presenting at conferences, and publishing results
AbbVie Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about AbbVie and has not been reviewed or approved by AbbVie.
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Retirement Support — Retirement programs are portrayed as a standout, with a dollar‑for‑dollar 401(k) match up to 6% and an additional annual company contribution based on age and service. Feedback suggests this materially boosts perceived total compensation for many U.S. employees.
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Parental & Family Support — Paid parental and caregiver leave are emphasized, including up to 12 weeks of fully paid parental leave for all parents and 4 weeks of paid caregiver leave in the U.S. Feedback suggests these policies are a meaningful differentiator for employees balancing family needs.
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Leave & Time Off Breadth — Time off is described as extensive, with tiered vacation that scales with tenure, 17 company holidays, and two paid volunteer days in the U.S. Feedback suggests the breadth of leave contributes notably to overall benefits satisfaction.
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AbbVie is a global biopharmaceutical company focused on creating medicines and solutions that put impact first — for patients, communities, and our world. We aim to address complex health issues and enhance people's lives through our core therapeutic areas: immunology, oncology, neuroscience, eye care, aesthetics and other areas of unmet need.
