Senior Principal Computational Biologist (m/f/d) focus on multi-omics

A career at Pfizer offers opportunity, ownership and impact.
All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.
Right now, we are seeking highly qualified candidates to fill the position:
Senior Principal Computational Biologist (m/f/d)
Focus: Multi-Omics & Research Data Engineering with Nextflow Expertise
Location: Berlin
Pfizer is seeking a highly skilled and driven computational biologist with a deep understanding of Nextflow pipeline development and research data engineering. This is a unique opportunity to join a pioneering team at the forefront of multi-omics innovation, where you will help shape the future of data-driven drug discovery.
We are looking for someone who thrives at the intersection of bioinformatics, software engineering, and large-scale data integration, and who is passionate about building scalable, reproducible, and production-ready solutions for omics data analysis.
What You Will Achieve
In this role, you will:

• Lead the design, development, and optimization of Nextflow-based pipelines for scalable and reproducible omics data processing.
• Architect and implement a robust omics data platform to support high-throughput analysis and integration of multi-modal datasets.
• Collaborate with machine learning experts to integrate advanced ML methods into omics workflows.
• Curate, harmonize, and integrate internal and public omics datasets to support hypothesis generation across the drug discovery pipeline.
• Develop and maintain ETL frameworks and data dissemination strategies for omics data.
• Drive the adoption of best practices in data engineering, pipeline versioning, and workflow orchestration.
• Engage with external partners and contribute to Pfizer's omics data strategy.
• Foster community engagement through onboarding, workshops, hackathons, and scientific talks.
• Publish and present your work in high-impact journals and conferences to strengthen Pfizer's scientific leadership.

What You Bring (Minimum Requirements)

• PhD in Computational Biology, Bioinformatics, Computer Science, or a related field, with 5+ years of experience in research data engineering or computational biology.
• Expert-level proficiency in Nextflow and workflow management systems for large-scale omics data processing.
• Strong background in data integration, curation, and analysis of NGS, single-cell, proteomics, or functional genomics datasets.
• Proven experience in Python development, including scientific libraries and full-stack engineering.
• Deep knowledge of PostgreSQL, ETL pipelines, and data modeling for research applications.
• Demonstrated ability to work with large, heterogeneous datasets in a drug discovery context.
• Strong publication record and a passion for translating data into actionable insights.
• Excellent communication and collaboration skills.

Bonus Points If You Have

• Experience with front-end technologies (TypeScript, ReactJS) and browser-based visualization.
• Familiarity with AI/ML frameworks (e.g., PyTorch, Lightning) and LLMs/RAG systems.
• Expertise in cloud-native architectures, CI/CD, and software engineering best practices.

Together we stand for:
Breakthroughs that change patients' lives - In order to fulfill our corporate purpose, a value-oriented corporate culture guides our actions. Pfizer's values are: Courage, Excellence, Equity & Joy .
Courage: One bold way we are achieving our goals is our company-wide digital transformation strategy. Our flat hierarchies enable short decision-making paths.
Excellence: We focus on what is really important, take responsibility, measure progress and work together in a spirit of trust. Together we rely on an agile way of working that encourages our employees to balance their private and work lives and to promote personal development.
Equity: We believe that different experiences are valuable, which is why every opinion is heard and valued. These experiences and opinions enrich the entire company. In this way, we promote a diverse and inclusive working environment in which colleagues in various Diversity, Equity & Inclusion (DE&I) working groups such as, e.g. Engage Empowered Women, LGBT*IQ , DisAbility, X-Gen.
Joy: If we experience our work as meaningful, we get a lot in return. We achieve this by being proud of the contribution we make, appreciating each other and sharing this with joy and recognition. Our BRAVO Award program gives us an appreciative opportunity to do so. Our employees benefit from a comprehensive company health management "Pfizer in Balance" also during working hours.
Visit our website for more Information at: Arbeiten bei Pfizer Deutschland
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