Kyverna Therapeutics is a patient-centered, clinical-stage biopharmaceutical company developing cell therapies for patients suffering from autoimmune diseases. Guided by our core values, Stay True to Why, Collaborate to Accelerate, Lead with Clarity, Boldly Innovative, and Own the Outcome, we are committed to transforming the future of treatment for autoimmune disease. Join us at the forefront of cell therapy innovation and help redefine what’s possible.
Title: Senior Director, Clinical Science
Location: Remote or Hybrid
Reports To: SVP, Clinical Development & Medical Affairs
Responsibilities
- Serve as the senior clinical scientist for CAR T-cell therapy clinical trials in autoimmune disease indications, in partnership with internal and external cross-functional teams
- Partner with clinical operations, biometrics, regulatory, and commercial teams to ensure alignment on strategy and execution
- Lead design, execution, and interpretation of clinical trials across assigned program
- Provide scientific input into clinical development plans, study protocols, investigator brochures, and regulatory submissions.
- Participate in the development of clinical trial documents including protocols, ICFs, clinical development plans, and publications.
- Lead the development of clinical sections of regulatory documents including the IB, safety updates, clinical study reports, and responses to Health Authorities in collaboration with the study physician.
- Represent Clinical Development for the assigned program with cross-functional leaders
- Represent Clinical Development for the assigned program with key opinion leaders and strategic partners to inform clinical and scientific strategy
- Represent Clinical Development for the study team in high-impact external settings (advisory boards, regulatory meetings, major congresses), as appropriate
- Contribute to external scientific narrative and positioning through publications, presentations, and collaborations.
- Ensure compliance with GCP, corporate policies, and applicable local regulations.
- Lead, mentor, and develop high-performing clinical scientists and other staff
- Foster a culture of innovation, accountability, and scientific rigor.
- Contribute to Clinical Development organizational design and capability building to support future pipeline growth and complexity.
Qualifications
- Advanced degree (Ph.D., Pharm.D., M.D., or equivalent) in a scientific or life sciences discipline required
- 10+ years of progressive experience in drug development, including significant experience across multiple programs, including late-stage global clinical trials
- Demonstrated success in developing and executing clinical strategies at a program level
- Experience in late-stage clinical trials required; experience with BLA/NDA filing preferred
- Experience in cell and gene therapy, immunology, autoimmune disease, or related fields preferred
- Deep understanding of global regulatory frameworks and clinical development pathways required
- Strong operational acumen with excellence and efficiency
- Exceptional communication and management skills
- Ability to operate independently and effectively in a fast-paced, highly dynamic environment
- Ability to travel up to 15% of the time
Skills Required
- Advanced degree such as Ph.D., Pharm.D., M.D., or equivalent in a scientific or life sciences discipline
- 10+ years of progressive experience in drug development
- Significant experience across multiple clinical development programs, including late-stage global clinical trials
- Demonstrated success developing and executing clinical strategies at the program level
- Experience in late-stage clinical trials
- Deep understanding of global regulatory frameworks and clinical development pathways
- Experience in cell and gene therapy, immunology, autoimmune disease, or related fields
- Strong operational acumen with excellence and efficiency
- Exceptional communication and management skills
- Ability to operate independently in a fast-paced, highly dynamic environment
- Ability to travel up to 15% of the time
What We Do
Kyverna is a cell therapy company engineering and developing a new class of curative living medicines for inflammatory and autoimmune diseases. Using its SmarTcell™ approach which includes synReg-T cell and synNotch CAR-T technology platforms, Kyverna reprograms T cells to target and selectively suppress or eliminate autoreactive immune cells. The company’s goal is to develop therapies that are selective, potent and durable to tame autoimmunity. We build interdisciplinary teams that bring a broad range of experiences and scientific expertise together to develop medicines that will free patients from the siege of autoimmune diseases and bring curiosity for exploring and creating the unknown. Our commitment to our employees is to foster an open, supportive, and inclusive environment where we create opportunities for individuals to learn and grow to their full potential at every level. synNotch is a trademark of Gilead/Kite.
.png){kind=logo}
